CAJ | 학술논문

聚乙二醇干扰素联合利巴韦林是丙型肝炎的标准抗病毒治疗方案,但治疗过程中不良事件较常发生.丙型肝炎病毒(HCV)的基因型、治疗早期的病毒动力学、基因位点的多态性等可用于预测抗病毒治疗的疗效.低剂量快速摄入、预防并发症等治疗策略有助于丙型肝炎患者完成抗病毒治疗.目前,直接抗病毒药物已开始用于基因1型的HCV感染患者,使得抗病毒疗效得到明显提高.此外,亲环素类抑制剂、维生素D等制剂可能与抗病毒治疗的疗效有关.此文对丙型肝炎抗病毒疗效的相关预测因子、标准治疗方案、治疗策略、新型抗病毒治疗制剂的研究等作了综述.
취을이순간우소연합리파위림시병형간염적표준항병독치료방안,단치료과정중불량사건교상발생.병형간염병독(HCV)적기인형、치료조기적병독동역학、기인위점적다태성등가용우예측항병독치료적료효.저제량쾌속섭입、예방병발증등치료책략유조우병형간염환자완성항병독치료.목전,직접항병독약물이개시용우기인1형적HCV감염환자,사득항병독료효득도명현제고.차외,친배소류억제제、유생소D등제제가능여항병독치료적료효유관.차문대병형간염항병독료효적상관예측인자、표준치료방안、치료책략、신형항병독치료제제적연구등작료종술.
Pegylated interferon plus ribavirin is still the standard treatment for hepatitis C,but the efficacy is often restricted by adverse events.HCV genotypes,viral dynamics during early treatment and gene polymorphism may be useful in predicting the efficacy of antiviral treatment.Several strategies have emerged to improve outcomes including low accelerating dose regimen (LADR) and prevention of complications.Direct antiviral drugs have been already used for HCV genotype 1 patients,and demonstrated improved efficacy.Besides,inhibitors and vitamin D may also be applied in antiviral therapy to improve the efficacy.This article reviews efficacy predictors,standard therapy,strategies and research on new medicaments in antiviral treatment of hepatitis C.