CAJ | 학술논문

近期国内学者对H7N9禽流感病毒的特性,包括病毒起源及多样性、血凝素蛋白及其突变体等进行了深入的研究.该病毒在家禽中为低致病性,但基因突变后不仅易感染人类,且出现高致病性.H7N9禽流感病毒是一种新型基因重配病毒,在家禽中以鹌鹑与鸡体内病毒复制最强.H7N9禽流感病毒对人类的致病机制主要是病毒感染后激发免疫应答,血液中产生过量的细胞因子和趋化因子,出现继发性噬血细胞综合征、多器官功能损害等.此外,H7N9禽流感病毒感染者的预后还与血管紧张素Ⅱ持续升高及与个体遗传(携带rs12252-C/C IFITM3基因型)等因素相关.此文对H7N9禽流感病毒相关研究结果进行了综述,为H7N9禽流感疫情的防控及危重症患者的救治提供参考.
근기국내학자대H7N9금류감병독적특성,포괄병독기원급다양성、혈응소단백급기돌변체등진행료심입적연구.해병독재가금중위저치병성,단기인돌변후불부역감염인류,차출현고치병성.H7N9금류감병독시일충신형기인중배병독,재가금중이암순여계체내병독복제최강.H7N9금류감병독대인류적치병궤제주요시병독감염후격발면역응답,혈액중산생과량적세포인자화추화인자,출현계발성서혈세포종합정、다기관공능손해등.차외,H7N9금류감병독감염자적예후환여혈관긴장소Ⅱ지속승고급여개체유전(휴대rs12252-C/C IFITM3기인형)등인소상관.차문대H7N9금류감병독상관연구결과진행료종술,위H7N9금류감역정적방공급위중증환자적구치제공삼고.
The origin,diversity,hemagglutinin protein and mutations of avian influenza A (H7N9) virus are widely studied recently.Although this virus is low-pathogenic in domestic poultry,it becomes highly pathogenic in human when gene mutations occur.The available evidence has revealed that the novel avian influenza A (H7N9) virus is a multiple gene reassortment,and virus shedding in quail and chickens is much higher than in other species.When human infected with H7N9 virus,immune responses will be activated,and massive cytokines and chemokine are produced,which may result in secondary hemophagocytic syndrome and multiple organ dysfunction.The prognosis of H7N9 viral infection may be associated with high level of angiotensin Ⅱ in plasma and the genetic trait of individuals (carrying rs12252-C/C genotype IFITM3).This paper reviews the recent progress on H7N9 virus infection,to provide reference for the control of human infection with H7N9 avian influenza virus and the management of severe cases.