中华临床感染病杂志
中華臨床感染病雜誌
중화림상감염병잡지
CHINESE JOURNAL OF CLINICAL INFECTIOUS DISEASES
2014年
3期
193-196
,共4页
张利娅%郑书发%杨大干%楼滨
張利婭%鄭書髮%楊大榦%樓濱
장리아%정서발%양대간%루빈
人乳头瘤病毒%基因型%感染%流行病学
人乳頭瘤病毒%基因型%感染%流行病學
인유두류병독%기인형%감염%류행병학
Human papillomavirus%Genotype%Infection%Epidemiology
目的 了解浙江省女性患者人乳头瘤病毒(HPV)感染情况及流行趋势.方法 对2011年1月至2013年12月浙江省11家哨点医院妇科门诊就诊患者开展HPV监测.采用导流杂交技术检测21种HPV亚型.不同年份HPV感染情况和不同年龄组HPV感染率比较采用x2检验.结果 共纳入14 569例患者,其中HPV感染3 552例,感染率为24.38％.21种HPV亚型中,感染率居前3位的是HPV-16(5.77％,840/14 569),HPV-52(4.71％,686/14 569)和HPV-58(4.52％,659/14 569).单一高危型HPV感染率为15.40％(2 244/14 569),单一低危型HPV感染率为2.92％(426/14 569),多重HPV亚型感染率为6.05％(882/14 569),其中多重HPV感染率呈逐年上升趋势(x2=23.65,P＜0.01).15 ～ 24岁和＞54岁的患者HPV感染率最高,分别为27.91％(211/756)和27.73％(439/1 583),与其他年龄组的感染率比较差异有统计学意义(x2=18.664,P＜0.01).结论 浙江省妇科门诊患者HPV感染率较高,且多重亚型混合感染形势严峻,15 ～ 24岁和＞54岁为感染的高危人群.
目的 瞭解浙江省女性患者人乳頭瘤病毒(HPV)感染情況及流行趨勢.方法 對2011年1月至2013年12月浙江省11傢哨點醫院婦科門診就診患者開展HPV鑑測.採用導流雜交技術檢測21種HPV亞型.不同年份HPV感染情況和不同年齡組HPV感染率比較採用x2檢驗.結果 共納入14 569例患者,其中HPV感染3 552例,感染率為24.38％.21種HPV亞型中,感染率居前3位的是HPV-16(5.77％,840/14 569),HPV-52(4.71％,686/14 569)和HPV-58(4.52％,659/14 569).單一高危型HPV感染率為15.40％(2 244/14 569),單一低危型HPV感染率為2.92％(426/14 569),多重HPV亞型感染率為6.05％(882/14 569),其中多重HPV感染率呈逐年上升趨勢(x2=23.65,P＜0.01).15 ～ 24歲和＞54歲的患者HPV感染率最高,分彆為27.91％(211/756)和27.73％(439/1 583),與其他年齡組的感染率比較差異有統計學意義(x2=18.664,P＜0.01).結論 浙江省婦科門診患者HPV感染率較高,且多重亞型混閤感染形勢嚴峻,15 ～ 24歲和＞54歲為感染的高危人群.
목적 료해절강성녀성환자인유두류병독(HPV)감염정황급류행추세.방법 대2011년1월지2013년12월절강성11가초점의원부과문진취진환자개전HPV감측.채용도류잡교기술검측21충HPV아형.불동년빈HPV감염정황화불동년령조HPV감염솔비교채용x2검험.결과 공납입14 569례환자,기중HPV감염3 552례,감염솔위24.38％.21충HPV아형중,감염솔거전3위적시HPV-16(5.77％,840/14 569),HPV-52(4.71％,686/14 569)화HPV-58(4.52％,659/14 569).단일고위형HPV감염솔위15.40％(2 244/14 569),단일저위형HPV감염솔위2.92％(426/14 569),다중HPV아형감염솔위6.05％(882/14 569),기중다중HPV감염솔정축년상승추세(x2=23.65,P＜0.01).15 ～ 24세화＞54세적환자HPV감염솔최고,분별위27.91％(211/756)화27.73％(439/1 583),여기타년령조적감염솔비교차이유통계학의의(x2=18.664,P＜0.01).결론 절강성부과문진환자HPV감염솔교고,차다중아형혼합감염형세엄준,15 ～ 24세화＞54세위감염적고위인군.
Objective To investigate the prevalence and trends of human papillomavirus (HPV)infections in gynecology outpatients in Zhejiang province.Methods Samples of cervical exfoliated cells were collected from gynecology outpatients in 11 sentinel hospitals in Zhejiang Province from January 2011 to December 2013.Twenty one HPV subtypes were detected by flow-through hybridization technique.Chisquare test was performed to analyze the prevalence rates of HPV infections in different years and in different age groups.Results A total of 14 569 patients were enrolled in the study,among whom 3 552 (24.38％)were positive for HPV.HPV-16 (5.77％,840/14 569),HPV-52 (4.71％,686/14 569) and HPV-58 (4.52％,659/14 569) were the most prevalent subtypes.Among all patients,2 244 (15.40％) were infected with a single high-risk subtype,426 (2.92％) were infected with a single low-risk subtype,and 882 (6.05％) were infected with multiple subtypes.The rate of multiple infection was on the rise during 2011 and 2013 (x2 =23.65,P ＜0.01).The positive rates of HPV in patients with 15-24 y age group and ＞54 y age group were 27.91％ (211/756) and 27.73％ (439/1 583) respectively,which were higher than those in other age groups (x2 =18.664,P ＜ 0.01).Conclusion HPV infection is popular in gynecology outpatients in Zhejiang province,especially in patients aged 15-24 y and ＞ 54 y,and a certain proportion of patients are infected with multiple subtypes.
