CAJ | 학술논문

HBx基因是一种多功能的调节因子,具有广泛的反式激活作用,能激活转录因子、抑制DNA修复,并调节细胞的增殖、转化及凋亡.近年来,HBx在乙型肝炎病毒相关性肾炎(HBV-GN)致病中的作用成为研究的热点.研究显示,HBx对肾小球系膜细胞增殖、足细胞及肾小管上皮细胞的损伤及凋亡存在广泛影响.此文就HBx的生物学特性及在肾脏损伤机制中的研究进展进行了综述.
HBx기인시일충다공능적조절인자,구유엄범적반식격활작용,능격활전록인자、억제DNA수복,병조절세포적증식、전화급조망.근년래,HBx재을형간염병독상관성신염(HBV-GN)치병중적작용성위연구적열점.연구현시,HBx대신소구계막세포증식、족세포급신소관상피세포적손상급조망존재엄범영향.차문취HBx적생물학특성급재신장손상궤제중적연구진전진행료종술.
HBx gene is a multifunctional regulator,which has extensive trans-activating effects,and can activate transcription factors,inhibit DNA repair and regulate cell proliferation,differentiation and apoptosis.In recent years,the role of HBx gene in pathogenesis of hepatitis B virus-associated glomemlonephritis (HBV-GN) has been extensively studied,and the results show that HBx can promote glomerular mesangial cell proliferation,and induce damage or apoptosis of podocytes and renal tubular epithelial cells.This paper reviews the research progress on biological characteristics of HBx and its role in pathogenesis of HBV-GN.