CAJ | 학술논문

幽门螺杆菌(Hp)是一种具有高感染率的致病菌,常导致终身感染.Hp在口腔中寄居可能是造成消化道疾病反复发作的一个重要原因,同时也会影响胃Hp根除治疗的疗效.由于口腔的微生态环境与胃内不同,细菌培养、快速尿素酶试验(RUT)、聚合酶链反应(PCR)等胃内Hp的检测方法在检测口腔Hp感染时结果存在很大差异.唾液Hp尿素酶抗原检测法(HPS)是一种免疫显色的图解化验法.通过唾液Hp培养和(或)HPS检测可探明口腔Hp的存在,从而可以通过制订胃、口同步治疗的全新方案,提高Hp根除率.此文就口腔Hp感染及其与胃Hp感染的相关性,口腔Hp检测与培养的新技术等最新进展作了综述.
유문라간균(Hp)시일충구유고감염솔적치병균,상도치종신감염.Hp재구강중기거가능시조성소화도질병반복발작적일개중요원인,동시야회영향위Hp근제치료적료효.유우구강적미생태배경여위내불동,세균배양、쾌속뇨소매시험(RUT)、취합매련반응(PCR)등위내Hp적검측방법재검측구강Hp감염시결과존재흔대차이.타액Hp뇨소매항원검측법(HPS)시일충면역현색적도해화험법.통과타액Hp배양화(혹)HPS검측가탐명구강Hp적존재,종이가이통과제정위、구동보치료적전신방안,제고Hp근제솔.차문취구강Hp감염급기여위Hp감염적상관성,구강Hp검측여배양적신기술등최신진전작료종술.
Helicobacter pylori (Hp) is of high prevalence and can cause lifelong infection.Hp can parasite in oral cavity,which may be not only an important cause of recurrent gastrointestinal diseases,but also affect Hp eradication in stomach.Bacterial culture,rapid urease test (RUT) and polymerase chain reaction (PCR) have been widely used in diagnosis of gastrointestinal Hp infections.While due to the difference of microbial environments in oral cavity and in stomach,there exit big disparities when they are used to detect Hp in oral cavity.Saliva Hp urease antigen detection method (HPS) is a graphic immune chromogenic assay.Hp salivary culture with HPS test can help to confirm the existence of Hp in oral cavity,so as to improve Hp eradication rate through concurrent treatment of gastrointestinal and oral Hp infections.The status of oral Hp infection,its correlation with gastric Hp infection,and new techniques of oral Hp detection and culture are reviewed in this article.