CAJ | 학술논문

目的探讨尿中N-乙酰-β-D-氨基葡萄糖苷酶(NAG)活力在急性百草枯中毒早期肾损害中的意义.方法检测44例急性百草枯患者人院后尿中NAG活力并与40例健康对照组进行比较.结果百草枯中毒组尿中NAG活力为(40.7±10.6) U/g Cr明显高于健康对照组[(18.6±5.1) U/g Cr],差异有统计学意义(P＜0.01).NAG活力≥25 U/g Cr中毒组30 d死亡率(34.4％)明显高于NAG活力＜25 U/gCr组(16.7％),两组病死率的差异有统计学意义(P＜0.01).结论尿中NAG活力≥25 U/g Cr组百草枯中毒病死率明显升高,尿中NAG活力对急性百草枯中毒早期肾损伤诊断可能有一定意义.
목적 탐토뇨중N-을선-β-D-안기포도당감매(NAG)활력재급성백초고중독조기신손해중적의의.방법 검측44례급성백초고환자인원후뇨중NAG활력병여40례건강대조조진행비교.결과백초고중독조뇨중NAG활력위(40.7±10.6) U/g Cr명현고우건강대조조[(18.6±5.1) U/g Cr],차이유통계학의의(P＜0.01).NAG활력≥25 U/g Cr중독조30 d사망솔(34.4％)명현고우NAG활력＜25 U/gCr조(16.7％),량조병사솔적차이유통계학의의(P＜0.01).결론 뇨중NAG활력≥25 U/g Cr조백초고중독병사솔명현승고,뇨중NAG활력대급성백초고중독조기신손상진단가능유일정의의.
Objectives To test the hypothesis that urine N-acetyl-beta-D-glucosaminidase (NAG) is an early biomarker for acute kidney injury in patients with acute paraquat poisoning.Methods Forty-four patients with paraquat intoxication and 40 age and gender-matched healthy control participants were recruited.The urine N-acetyl-beta-D-glucosaminidase was determined by spectrophotometric methods.Results The urine Nacetyl-beta-D-glucosaminidase activities in the patients with paraquat poisoning were higher than the corresponding values in the control participants (P＜0.01); The prevalence rate of mortality was significantly higher in subjects with N-acetyl-beta-D-glucosaminidase activities ≥25 U/g Cr than in those N-acetyl-beta-Dglucosaminidase activities ＜25 U/g Cr (34.4％ vs 16.7％,P＜0.01).Conclusions The urine N-acetyl-beta-Dglucosaminidase could be used as an early biomarker for acute kidney injury and predictor of mortality in patients with acute paraquat intoxication.