中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2009年
12期
991-993
,共3页
吡啶类%雌二醇%绝经期%骨质疏松%绝经后
吡啶類%雌二醇%絕經期%骨質疏鬆%絕經後
필정류%자이순%절경기%골질소송%절경후
Pyridines%Estradiol%Menopause%Osteoporosis,postmenopausal
目的 了解正常围绝经期及绝经期妇女尿脱氧吡啶啉(Deoxy pyridinoline,DPD)和尿肌酐(Creatinine,Cr)比值(DPD/cr)及其与血雌二醇的关系. 方法正常围绝经期及绝经期妇女80例,其中围绝经期妇女42例,按病史是否超过1年分为围绝经期1组(25例,<1年)和围绝经期2组(17例,≥1年),绝经期妇女38例,绝经年限分为<5年组12例、5～15年组17例和>15年组9例;测定其尿DPD、尿肌酐及血雌二醇,尿DPD由化学发光法测定. 结果围绝经期2组DPD/Cr4.80±0.75,高于围绝经期1组3.92±1.05(t=2.961,P=0.005),而血雌二醇(27.8±15.7)ng/L,低于围绝经期1组(60.1±36.5)ng/L(t=3.917,P=0.000),差异均有统计学意义;两组DPD/Cr和雌二醇呈直线负相关关系(r=0.446,P<0.05).绝经期妇女<5年组DPD/Cr高于5～15年组和>15年组,差异有统计学意义(P<0.05),而>15年组血雌二醇水平低于<5年组和5～15年组(P<0.05),其余两组之间比较差异均无统计学意义(P>0.05).本组病例中雌二醇<30 ng/L妇女的DPD/cr高于雌二醇≥30 ng/L的妇女.差异有统计学意义(P<0.005). 结论尿DPD/Cr能敏感、特异地反映体内骨代谢状况,是围绝经期及绝经期妇女最有价值的骨代谢观测指标;围绝经期病史超过1年及绝经<5年妇女骨代谢增强明显,提示该阶段是预防和治疗骨质疏松的有效时机;建议绝经期和围绝经期妇女雌二醇>30 ng/L为雌激素治疗的一项重要观测指标.
目的 瞭解正常圍絕經期及絕經期婦女尿脫氧吡啶啉(Deoxy pyridinoline,DPD)和尿肌酐(Creatinine,Cr)比值(DPD/cr)及其與血雌二醇的關繫. 方法正常圍絕經期及絕經期婦女80例,其中圍絕經期婦女42例,按病史是否超過1年分為圍絕經期1組(25例,<1年)和圍絕經期2組(17例,≥1年),絕經期婦女38例,絕經年限分為<5年組12例、5～15年組17例和>15年組9例;測定其尿DPD、尿肌酐及血雌二醇,尿DPD由化學髮光法測定. 結果圍絕經期2組DPD/Cr4.80±0.75,高于圍絕經期1組3.92±1.05(t=2.961,P=0.005),而血雌二醇(27.8±15.7)ng/L,低于圍絕經期1組(60.1±36.5)ng/L(t=3.917,P=0.000),差異均有統計學意義;兩組DPD/Cr和雌二醇呈直線負相關關繫(r=0.446,P<0.05).絕經期婦女<5年組DPD/Cr高于5～15年組和>15年組,差異有統計學意義(P<0.05),而>15年組血雌二醇水平低于<5年組和5～15年組(P<0.05),其餘兩組之間比較差異均無統計學意義(P>0.05).本組病例中雌二醇<30 ng/L婦女的DPD/cr高于雌二醇≥30 ng/L的婦女.差異有統計學意義(P<0.005). 結論尿DPD/Cr能敏感、特異地反映體內骨代謝狀況,是圍絕經期及絕經期婦女最有價值的骨代謝觀測指標;圍絕經期病史超過1年及絕經<5年婦女骨代謝增彊明顯,提示該階段是預防和治療骨質疏鬆的有效時機;建議絕經期和圍絕經期婦女雌二醇>30 ng/L為雌激素治療的一項重要觀測指標.
목적 료해정상위절경기급절경기부녀뇨탈양필정람(Deoxy pyridinoline,DPD)화뇨기항(Creatinine,Cr)비치(DPD/cr)급기여혈자이순적관계. 방법정상위절경기급절경기부녀80례,기중위절경기부녀42례,안병사시부초과1년분위위절경기1조(25례,<1년)화위절경기2조(17례,≥1년),절경기부녀38례,절경년한분위<5년조12례、5～15년조17례화>15년조9례;측정기뇨DPD、뇨기항급혈자이순,뇨DPD유화학발광법측정. 결과위절경기2조DPD/Cr4.80±0.75,고우위절경기1조3.92±1.05(t=2.961,P=0.005),이혈자이순(27.8±15.7)ng/L,저우위절경기1조(60.1±36.5)ng/L(t=3.917,P=0.000),차이균유통계학의의;량조DPD/Cr화자이순정직선부상관관계(r=0.446,P<0.05).절경기부녀<5년조DPD/Cr고우5～15년조화>15년조,차이유통계학의의(P<0.05),이>15년조혈자이순수평저우<5년조화5～15년조(P<0.05),기여량조지간비교차이균무통계학의의(P>0.05).본조병례중자이순<30 ng/L부녀적DPD/cr고우자이순≥30 ng/L적부녀.차이유통계학의의(P<0.005). 결론뇨DPD/Cr능민감、특이지반영체내골대사상황,시위절경기급절경기부녀최유개치적골대사관측지표;위절경기병사초과1년급절경<5년부녀골대사증강명현,제시해계단시예방화치료골질소송적유효시궤;건의절경기화위절경기부녀자이순>30 ng/L위자격소치료적일항중요관측지표.
Objective To investigate the urine deoxypyridinoline/creatinine ratio (DPD/Cr) and its relationship with serum estradiol (E_2) in perimenopausal and menopausal women. Methods The levels of urine DPD, Cr and serum E_2 were measured in 42 perimenopausal women and 38 menopausal women. Perimenopausal women were divided into 2 groups: group Al (n=25, history < 1 year) and group A2 (n=17, history = 1 year). Menopausal women were divided into 3 groups: group B (n=12, history < 5 years), group C (n=17, 5 years = history < 15 years) and group D (n=9, history = 15 years). Urine DPD was detected by the chemiluminescent immunoassay (CLI-A). Results Higher urine DPD/Cr but lower E2 levels were observed in group A2 than in group Al (both P < 0. 001) , and there was negative linear correlation between DPD/Cr and E2 in perimenopausal women (r=-0. 446, P<0. 05). Higher urine DPD/Cr were observed in group B than in group C and D (both P<0.05), and lower E_2 levels were showed in group D (both P<0. 05). Of all cases, urine DPD/Cr were higher in serum E_2 < 30 ng/L than in serum E_2 = 30 ng/L (P < 0. 005). Conclusions Urine DPD/Cr can reflect bone metabolism sensitively and differentially, it is a valuable marker of bone metabolism for perimenopausal and menopausal women. High bone metabolism occurs in perimenopausal women (history =1 year) and menopausal women (history < 5 years), indicating an effective opportunity for early prevention and treatement of postmenopausal osteoporosis. Serum E_2 > 30ng/L may be an important parameter for estradiol treatment.
