CAJ | 학술논문

目的探讨新疆汉族和维吾尔族人群阿尔茨海默病(AD)患病的危险因素. 方法对新疆地区汉族和维吾尔族≥50岁常住人口进行流行病学调查,采用中文简易精神状态量表(MMSE)进行可疑AD初筛,MMSE分值低于划界分者再用Hachinski(HIS)缺血指数量表和日常生活能力量表(ADL)进一步细查,最后根据美国国立神经病语言障碍卒中研究所AD及相关疾病协会(NINCDS/ADRDA)标准诊断出很可能AD患者.采用病例对照研究方法按与病例组民族相同、年龄相同或相近的原则以1:2比例随机选出对照组,分别对不同种族人群AD患病相关因素进行单因素及多因素Logistic回归分析. 结果汉族很可能AD组109例,对照组218例；维吾尔族很可能AD组127例,对照组254例.Logistic回归分析结果显示在汉族人群中,女性、血清总胆固醇(TC)升高者及低密度脂蛋白胆固醇(LDL-C)升高者患AD的风险分别是男性、非TC升高者及非LDL-C升高者的3.078、1.369和2.794倍(OR=3.078、1.369、2.794,均P＜0.05)；在维吾尔族人群中,女性、有脑外伤史、三酰甘油(TG)升高及TC升高者患AD的风险分别是男性、无脑外伤史者、非TG升高者及非TC升高者的3.279、3.447、1.407和1.746倍(OR=3.279、3.447、1.407、1.746,均P＜0.05)结论女性、高胆固醇血症是汉族和维吾尔族人群患AD共同的危险因素；在汉族人群中,高LDLC亦是AD的危险因素,而在维吾尔族人群中,脑外伤史和高TG亦是AD的危险因素.
목적 탐토신강한족화유오이족인군아이자해묵병(AD)환병적위험인소. 방법 대신강지구한족화유오이족≥50세상주인구진행류행병학조사,채용중문간역정신상태량표(MMSE)진행가의AD초사,MMSE분치저우화계분자재용Hachinski(HIS)결혈지수량표화일상생활능역량표(ADL)진일보세사,최후근거미국국립신경병어언장애졸중연구소AD급상관질병협회(NINCDS/ADRDA)표준진단출흔가능AD환자.채용병례대조연구방법안여병례조민족상동、년령상동혹상근적원칙이1:2비례수궤선출대조조,분별대불동충족인군AD환병상관인소진행단인소급다인소Logistic회귀분석. 결과 한족흔가능AD조109례,대조조218례；유오이족흔가능AD조127례,대조조254례.Logistic회귀분석결과현시재한족인군중,녀성、혈청총담고순(TC)승고자급저밀도지단백담고순(LDL-C)승고자환AD적풍험분별시남성、비TC승고자급비LDL-C승고자적3.078、1.369화2.794배(OR=3.078、1.369、2.794,균P＜0.05)；재유오이족인군중,녀성、유뇌외상사、삼선감유(TG)승고급TC승고자환AD적풍험분별시남성、무뇌외상사자、비TG승고자급비TC승고자적3.279、3.447、1.407화1.746배(OR=3.279、3.447、1.407、1.746,균P＜0.05)결론 녀성、고담고순혈증시한족화유오이족인군환AD공동적위험인소；재한족인군중,고LDLC역시AD적위험인소,이재유오이족인군중,뇌외상사화고TG역시AD적위험인소.
Objective To investigate the related factors for Alzheimer's disease(AD) in Han versus Uygur populations in Uygur Autonomous Region.Methods A case-control study was conducted.Firstly,people over 50 years old were involved in epidemiology inquisition in Xinjiang Uygur Autonomous Region.Then we screened for dementia by MMSE and scrutinized the person who got the score of MMSE for illiteracy(≤17),elementary school(＜20),middle school and above it(＜ 24)by Hachinski Ischemic Score(HIS) and activity of daily living scale(ADL).Finally,AD cases were diagnosed by standard of the national institute of neurologic,communicative disorders and stroke and AD-related disorders association (NINCDS-ADRDA),and controls were selected based on age roughly.Univariate and multivariate analysis of related factors for AD in the two populations were conducted by using logistic regression mode.Results There were 109 AD cases and 218 controls in Han population and 127 AD cases and 254 controls in Uygur population.Logistic regression analysis showed that the risk for AD in Han population was increased by 3.078,1.369 and 2.794 folds respectively in women,people with high level of serum total cholesterol and people with low-density lipoprotein cholesterol as compared with men,people with normal level of serum total cholesterol and people with low-density lipoprotein cholesterol(OR =3.078,1.369 and 2.794,respectively,all P＜ 0.05); and the risk for AD in Uygur population was increased by 3.279,3.447,1.407 and 1.746 folds respectively in women,people with brain trauma history,and people with high level of serum triglyceride and total cholesterol as compared with men,people without brain trauma history and with normal level of serum triglyceride and total cholesterol(OR=3.279,3.447,1.407 and 1.746,all P＜ 0.05).Conclusions The study demonstrates that female and high total cholesterol are the risk factors for AD in both of Han and Uygur populations.High level of low-density lipoprotein cholesterol is one of the risk factors for AD in Han population,and brain trauma history and high level of serum triglyceride are risk factors for AD in Uygur population.