中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2014年
4期
429-432
,共4页
康东红%郭涛%王燕%张洪美%冯潇雨
康東紅%郭濤%王燕%張洪美%馮瀟雨
강동홍%곽도%왕연%장홍미%풍소우
维生素D缺乏
維生素D缺乏
유생소D결핍
Vitamin%D%deficiency
目的 探讨济南城镇居民维生素D的营养状况,为防治与维生素D不足有关的慢性疾病提供依据. 方法 在本院所管辖的3个医疗保健社区分层随机抽取受检者1478例,年龄30～90岁,平均(58.4±13.0)岁;其中男性602例,平均年龄(59.8±13.0)岁;女性876例,平均年龄(57.4±12.9)岁;按10岁间隔年龄段分组.用酶联免疫吸附法(ELISA)测定血25羟维生素D[25(OH)D]水平.维生素D水平分布的界定:[25(OH) D]≥75.0 nmol/L为维生素D营养充足,50.0～74.9nmol/I为临界,25.0～49.9 nmol/L为不足,＜25.0 nmol/L为缺乏.应用SPSS13.0软件进行统计分析. 结果 (1)男性[25(OH) D]水平58.6 nmol/L(95％ CI:56.7～60.5 nmol/L),女性54.2nmol/L(95％ CI:52.8～55.8 nmol/L),均低于75 nmol/L;70～79岁女性[25(OH) D]为49.1 nmol/L(95％CI:45.7～52.5 nmol/L);80～90岁为41.7 nmol/L(95％ CI:38.2～46.7 nmol/L),低于50nmol/L; (2)维生素D缺乏、不足、临界和充足,男性分别为5.6％、33.4％、36.5％和24.4％,女性分别为6.5％、42.9％、32.6％和18.1％;维生素D缺乏及不足发生率随年龄的增长而上升(男性:x2=33.68,P=0.004;女性:x2=55.7,P＜0.001);60岁以上女性维生素D缺乏及不足较男性高,差异有统计学意义(60～69岁:x2=9.387,P=0.025;80～90岁:x2=8.896,P=0.031);(3) [25(OH) D]水平以冬季最低[48.8 nmol/L(95％CI:46.8～50.9 nmol/L)],秋季最高[60.2 nmol/L(95％CI:58.0～62.3 nmol/L)];维生素D缺乏及不足发生率以冬季最高为7.6％及46.2％,秋季最低为5.5％及29.0％,差异有统计学意义(x2=18.36,P=0.031). 结论 城镇居民普遍存在维生素D缺乏及不足,以老年人群及其女性较为严重.血[25(OH) D]水平及分布与季节变化有关,冬季维生素D缺乏及不足发生率较高.
目的 探討濟南城鎮居民維生素D的營養狀況,為防治與維生素D不足有關的慢性疾病提供依據. 方法 在本院所管轄的3箇醫療保健社區分層隨機抽取受檢者1478例,年齡30～90歲,平均(58.4±13.0)歲;其中男性602例,平均年齡(59.8±13.0)歲;女性876例,平均年齡(57.4±12.9)歲;按10歲間隔年齡段分組.用酶聯免疫吸附法(ELISA)測定血25羥維生素D[25(OH)D]水平.維生素D水平分佈的界定:[25(OH) D]≥75.0 nmol/L為維生素D營養充足,50.0～74.9nmol/I為臨界,25.0～49.9 nmol/L為不足,＜25.0 nmol/L為缺乏.應用SPSS13.0軟件進行統計分析. 結果 (1)男性[25(OH) D]水平58.6 nmol/L(95％ CI:56.7～60.5 nmol/L),女性54.2nmol/L(95％ CI:52.8～55.8 nmol/L),均低于75 nmol/L;70～79歲女性[25(OH) D]為49.1 nmol/L(95％CI:45.7～52.5 nmol/L);80～90歲為41.7 nmol/L(95％ CI:38.2～46.7 nmol/L),低于50nmol/L; (2)維生素D缺乏、不足、臨界和充足,男性分彆為5.6％、33.4％、36.5％和24.4％,女性分彆為6.5％、42.9％、32.6％和18.1％;維生素D缺乏及不足髮生率隨年齡的增長而上升(男性:x2=33.68,P=0.004;女性:x2=55.7,P＜0.001);60歲以上女性維生素D缺乏及不足較男性高,差異有統計學意義(60～69歲:x2=9.387,P=0.025;80～90歲:x2=8.896,P=0.031);(3) [25(OH) D]水平以鼕季最低[48.8 nmol/L(95％CI:46.8～50.9 nmol/L)],鞦季最高[60.2 nmol/L(95％CI:58.0～62.3 nmol/L)];維生素D缺乏及不足髮生率以鼕季最高為7.6％及46.2％,鞦季最低為5.5％及29.0％,差異有統計學意義(x2=18.36,P=0.031). 結論 城鎮居民普遍存在維生素D缺乏及不足,以老年人群及其女性較為嚴重.血[25(OH) D]水平及分佈與季節變化有關,鼕季維生素D缺乏及不足髮生率較高.
목적 탐토제남성진거민유생소D적영양상황,위방치여유생소D불족유관적만성질병제공의거. 방법 재본원소관할적3개의료보건사구분층수궤추취수검자1478례,년령30～90세,평균(58.4±13.0)세;기중남성602례,평균년령(59.8±13.0)세;녀성876례,평균년령(57.4±12.9)세;안10세간격년령단분조.용매련면역흡부법(ELISA)측정혈25간유생소D[25(OH)D]수평.유생소D수평분포적계정:[25(OH) D]≥75.0 nmol/L위유생소D영양충족,50.0～74.9nmol/I위림계,25.0～49.9 nmol/L위불족,＜25.0 nmol/L위결핍.응용SPSS13.0연건진행통계분석. 결과 (1)남성[25(OH) D]수평58.6 nmol/L(95％ CI:56.7～60.5 nmol/L),녀성54.2nmol/L(95％ CI:52.8～55.8 nmol/L),균저우75 nmol/L;70～79세녀성[25(OH) D]위49.1 nmol/L(95％CI:45.7～52.5 nmol/L);80～90세위41.7 nmol/L(95％ CI:38.2～46.7 nmol/L),저우50nmol/L; (2)유생소D결핍、불족、림계화충족,남성분별위5.6％、33.4％、36.5％화24.4％,녀성분별위6.5％、42.9％、32.6％화18.1％;유생소D결핍급불족발생솔수년령적증장이상승(남성:x2=33.68,P=0.004;녀성:x2=55.7,P＜0.001);60세이상녀성유생소D결핍급불족교남성고,차이유통계학의의(60～69세:x2=9.387,P=0.025;80～90세:x2=8.896,P=0.031);(3) [25(OH) D]수평이동계최저[48.8 nmol/L(95％CI:46.8～50.9 nmol/L)],추계최고[60.2 nmol/L(95％CI:58.0～62.3 nmol/L)];유생소D결핍급불족발생솔이동계최고위7.6％급46.2％,추계최저위5.5％급29.0％,차이유통계학의의(x2=18.36,P=0.031). 결론 성진거민보편존재유생소D결핍급불족,이노년인군급기녀성교위엄중.혈[25(OH) D]수평급분포여계절변화유관,동계유생소D결핍급불족발생솔교고.
Objective To explore the vitamin D nutritional status of urban residents in Jinan,in order to provide the basis for the prevention and treatment of chronic diseases associated with vitamin D insufficiency.Methods 1478 cases aged 30-90 years,including 602 men (59.8± 13.0) years on average and 876 women (57.4±12.9) years on average were selected by a stratified random sampling from 3 community medical care institutions in Jinan.Subjects were divided into six groups according to the 10-year interval.Serum 25-hydroxyvitamin D [25(OH) D] level was measured by enzyme-linked immunosorbent assay (ELISA).Serum [25(OH) D] level ≥ 75 nmol/L was defined as vitamin D sufficient,(50.0 ～ 74.9) nmol/L as vitamin D critical value,25.0 ～ 49.9 nmol/L as vitamin D insufficiency,＜ 25 nmol/L as vitamin D deficiency.All data processing and statistical analysis were finished by SPSS 13.0.Results The average level of [25 (OH) D] was 58.60 nmol/L in males [95％ CI:56.7-60.5 nmol/L] and 54.17 nmol/L in females [95％ CI:52.8-55.8 nmol/L],which were less than 75 nmol/L.The average level of [[25(OH) D] was 49.1nmol/L in females aged 70-79 years (95％CI:45.7～52.5 nmol/L),41.7 nmol/L in females aged 80-90 years (95％CI:38.2 ～46.7 nmol/L),which were less than 50 nmol/L.The percentage of cases with vitamin D deficiency,insufficiency,critical value,and sufficiency was 5.6％,33.4％,36.5％,24.4％ in males,and 6.5％,42.9％,32.6％,18.1％ in female respectively.The incidence of vitamin D deficiency and insufficiency was increased with ageing (male:x2 =33.68 P＜0.01,female:x2 =55.7,P＜0.001).The percentage of vitamin D deficiency and insufficiency was more in females than in males (60-69 years old:x2=9.387,P＜0.05,80-90 years old:x2=8.896,P＜0.05).The [25 (OH) D] level was lowest in winter (48.8 nmol/L,95％CI:46.8～50.9 nmol/L) and highest in autumn (60.2 nmol/L,95％ CI:58.0～62.3 nmol/L).The incidence of vitamin D deficiency and insufficiency was highest in winter (x2 =18.364,P＜0.05).Conclusions Vitamin D deficiency and insufficiency are widely prevalent in urban residents,which is more severe in the elderly and females.Serum [25(OH) D] level is related to season,and the vitamin D deficiency and insufficiency are severe in winter.
