CAJ | 학술논문

目的探讨多态性上皮黏蛋白1 (mucin 1,MUC1)和原癌基因蛋白质(proto-oncogene proteins C-myc,C-Myc)基因在老年甲状腺乳头状癌(PTC)患者中的表达和临床意义. 方法应用免疫组化法检测30例腺瘤旁正常甲状腺组织、35例结节性甲状腺肿和58例PTC标本中MUC1和C-myc的表达水平. 结果 MUC1基因在甲状腺癌中表达率为77.6％(45/58),MUC1在有局部浸润和淋巴结转移患者中的检出率分别为90.0％(9/10)和88.2％(15/17).C-myc基因在甲状腺癌中阳性率为81.0％ (47/58);C-myc在淋巴结转移组中的检出率为100.0％ (17/17). 结论 MUC1和C myc的阳性表达在甲状腺良恶性病变间有差异,并与甲状腺癌的转移有关.
목적 탐토다태성상피점단백1 (mucin 1,MUC1)화원암기인단백질(proto-oncogene proteins C-myc,C-Myc)기인재노년갑상선유두상암(PTC)환자중적표체화림상의의. 방법 응용면역조화법검측30례선류방정상갑상선조직、35례결절성갑상선종화58례PTC표본중MUC1화C-myc적표체수평. 결과 MUC1기인재갑상선암중표체솔위77.6％(45/58),MUC1재유국부침윤화림파결전이환자중적검출솔분별위90.0％(9/10)화88.2％(15/17).C-myc기인재갑상선암중양성솔위81.0％ (47/58);C-myc재림파결전이조중적검출솔위100.0％ (17/17). 결론 MUC1화C myc적양성표체재갑상선량악성병변간유차이,병여갑상선암적전이유관.
Objective To study the changes of expression of mucin1 (MUC1) and protooncogene proteins C-myc (C-myc) gene in elderly papillary thyroid carcinoma.Methods The expression levels of MUC1 and C-myc were examined by immunohistochemical methods in 58 sample of thyroid carcinoma,35 nodular goiter and in 30 normal thyroid tissue.Results The detective rate of MUC1 in 58 specimens of thyroid carcinoma was 77.6％ (45/58),while 90.0％ (9/10) in those with infiltration and 88.2 ％ (15/17) in those with metastasis.The detective rate of C-myc in 58 specimens of thyroid carcinoma was 81.0 ％ (47/58),and 100.0 ％ (17/17) in those with metastasis.Conclusions The differences in MUC1 or C myc expression and in thyroid carcinoma infiltration and lymph node metastasia between benign versus malignant thyroid tumor are statistically significant.