CAJ | 학술논문

目的探讨老年和中青年发病的溃疡性结肠炎(UC)患者在临床表现、内镜、病理及治疗方法等方面的差异. 方法对1994-2010年间北京大学第三医院住院的178例UC患者进行回顾性分析,分为老年组(≥60岁发病)27例及中青年组(＜60岁发病)151例,比较两组在临床表现、内镜、病理以及主要实验室检查、病情严重程度分型、治疗方法等方面的异同. 结果老年组男性21例,女性6例;中青年组男性83例,女性68例,老年组中男性比率(77.8％)高于中青年组(55.0％)(P＜0.05);两组初发型和慢性复发型的比率差异无统计学意义;老年组腹痛比率(44.4％)低于中青年组(78.8％)(P＜0.05).肠镜下病变分级:老年组Ⅰ、Ⅱ级比率(70.4％)明显高于中青年组(39.9％),Ⅲ～Ⅳ级比率(29.6％)明显低于中青年组(60.1％)(P＜0.05);两组间病变范围、特征性病理表现、诱导缓解的常用药物及治疗方式差异无统计学意义(P＞0.05). 结论同中青年发病的UC患者比较,老年发病的UC患者中男性比率明显升高,腹痛相对少见,内镜下病变相对较轻.
목적 탐토노년화중청년발병적궤양성결장염(UC)환자재림상표현、내경、병리급치료방법등방면적차이. 방법 대1994-2010년간북경대학제삼의원주원적178례UC환자진행회고성분석,분위노년조(≥60세발병)27례급중청년조(＜60세발병)151례,비교량조재림상표현、내경、병리이급주요실험실검사、병정엄중정도분형、치료방법등방면적이동. 결과 노년조남성21례,녀성6례;중청년조남성83례,녀성68례,노년조중남성비솔(77.8％)고우중청년조(55.0％)(P＜0.05);량조초발형화만성복발형적비솔차이무통계학의의;노년조복통비솔(44.4％)저우중청년조(78.8％)(P＜0.05).장경하병변분급:노년조Ⅰ、Ⅱ급비솔(70.4％)명현고우중청년조(39.9％),Ⅲ～Ⅳ급비솔(29.6％)명현저우중청년조(60.1％)(P＜0.05);량조간병변범위、특정성병리표현、유도완해적상용약물급치료방식차이무통계학의의(P＞0.05). 결론 동중청년발병적UC환자비교,노년발병적UC환자중남성비솔명현승고,복통상대소견,내경하병변상대교경.
Objective To analyze the differences in the clinical characteristics,endoscopy,pathology and therapy between the patients with new onset ulcerative colitis(UC) in the elderly versus youth and middle-aged patients.Methods A review analysis was carried out in the 178 hospitalized patients with UC in Third Hospital of Peking University from 1994 to 2010.The patients were divided into two groups according to the age of onset:UC onset at age of 60 years and older were enrolled in elderly group; UC onset at age less than sixty years were enrolled in youth and middle-aged group.The data of clinical manifestation,endoscopy,pathology,laboratory test,the severity of disease classification and therapy were analyzed and compared between the two groups.Results The elderly group consisted of 21 men and 6 women.The youth and middle-aged group consisted of 83 men and 68 women.The ratio of male was higher in elderly group than in youth and middle-aged group (77.8％ vs.55.0％,P＜0.05).No significant difference in the clinical type of UC was observed (P＞0.05).The ratio of abdominal pain in elderly group was lower than in youth and middle-aged group (44.4％ vs.78.8％,P＜0.05).There were no significant differences in other symptoms,laboratory test and the severity of disease between the two groups (all P＞0.05).The ratio of Grade Ⅰ and Ⅱwas much higher in the elderly than in youth-middle-aged group(70.4％ vs.39.9％,P＜0.05),but the ratio of Grade Ⅲ and Ⅳ was much lower in the elderly than in youth-middle group(29.6％ vs.60.1％,P＜0.05).No significant differences between the two groups were found in the extent of disease,pathological characteristics and therapy (all P＞0.05).Conclusions Compared with the youth and middle-aged patients with onset UC,the ratio of male patients was higher,the ratio of abdominal pain was lower,and the severity of endoscopic manifestation was less in the elderly patients with onset UC.