中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2014年
5期
518-520
,共3页
曹鸿玮%王菲菲%杨俊亚%王瑞%郑晓红
曹鴻瑋%王菲菲%楊俊亞%王瑞%鄭曉紅
조홍위%왕비비%양준아%왕서%정효홍
冷冻疗法%疱疹,带状%神经痛,带状疱疹后
冷凍療法%皰疹,帶狀%神經痛,帶狀皰疹後
냉동요법%포진,대상%신경통,대상포진후
Cryotherapy%Herpes zoster%Neuralgia,postherpetic
目的 探讨液氮冷冻疗法联合阿昔洛韦片、甲钴胺分散片口服治疗老年人带状疱疹的疗效和安全性. 方法 将520例老年人带状疱疹患者随机数字表法分为试验组和对照组,每组各260例,对照组患者口服阿昔洛韦片和甲钴胺分散片治疗,试验组在对照组用药的基础上加用液态氮冷冻治疗,用棉签蘸取液氮在皮损处轻擦,1次/d,共5次.在治疗的第5、14、30天随访患者,观察两组患者是否有新水疱出现、干燥、结痂情况,记录皮疹止疱时间、结痂时间、结痂脱落时间、疼痛消退时间和后遗神经痛(postherpetic neuralgia,PHN)情况. 结果 试验组有效率为93.9％(244/260),高于对照组84.2％(219例),差异有统计学意义(x2=12.32,P＜0.05).试验组患者结痂、水疱干燥、疼痛消退时间分别为(2.6±0.8)d、(8.2±1.7)d、(9.2±2.5)d,均低于对照组(4.8±1.4)d,(11.3±2.2)d,(12.8±3.1)d(均P＜0.01).试验组止疱时间(1.9±0.6)d与对照组(1.8±0.8)d比较,差异无统计学意义(t=0.933,P＞0.05).试验组患者后遗神经痛发生率6.9％(18/260),与对照组患者后遗神经痛发生率18.1％(47/260),差异有统计学意义(x2=14.787,P＜0.01). 结论 液氮冷冻联合阿昔洛韦片、甲钴胺分散片口服疗效优于阿昔洛韦片、甲钴胺分散片口服治疗,试验组具有水疱干燥、结痂时间缩短、疼痛消退快、后遗神经痛发生减少的优点.
目的 探討液氮冷凍療法聯閤阿昔洛韋片、甲鈷胺分散片口服治療老年人帶狀皰疹的療效和安全性. 方法 將520例老年人帶狀皰疹患者隨機數字錶法分為試驗組和對照組,每組各260例,對照組患者口服阿昔洛韋片和甲鈷胺分散片治療,試驗組在對照組用藥的基礎上加用液態氮冷凍治療,用棉籤蘸取液氮在皮損處輕抆,1次/d,共5次.在治療的第5、14、30天隨訪患者,觀察兩組患者是否有新水皰齣現、榦燥、結痂情況,記錄皮疹止皰時間、結痂時間、結痂脫落時間、疼痛消退時間和後遺神經痛(postherpetic neuralgia,PHN)情況. 結果 試驗組有效率為93.9％(244/260),高于對照組84.2％(219例),差異有統計學意義(x2=12.32,P＜0.05).試驗組患者結痂、水皰榦燥、疼痛消退時間分彆為(2.6±0.8)d、(8.2±1.7)d、(9.2±2.5)d,均低于對照組(4.8±1.4)d,(11.3±2.2)d,(12.8±3.1)d(均P＜0.01).試驗組止皰時間(1.9±0.6)d與對照組(1.8±0.8)d比較,差異無統計學意義(t=0.933,P＞0.05).試驗組患者後遺神經痛髮生率6.9％(18/260),與對照組患者後遺神經痛髮生率18.1％(47/260),差異有統計學意義(x2=14.787,P＜0.01). 結論 液氮冷凍聯閤阿昔洛韋片、甲鈷胺分散片口服療效優于阿昔洛韋片、甲鈷胺分散片口服治療,試驗組具有水皰榦燥、結痂時間縮短、疼痛消退快、後遺神經痛髮生減少的優點.
목적 탐토액담냉동요법연합아석락위편、갑고알분산편구복치료노년인대상포진적료효화안전성. 방법 장520례노년인대상포진환자수궤수자표법분위시험조화대조조,매조각260례,대조조환자구복아석락위편화갑고알분산편치료,시험조재대조조용약적기출상가용액태담냉동치료,용면첨잠취액담재피손처경찰,1차/d,공5차.재치료적제5、14、30천수방환자,관찰량조환자시부유신수포출현、간조、결가정황,기록피진지포시간、결가시간、결가탈락시간、동통소퇴시간화후유신경통(postherpetic neuralgia,PHN)정황. 결과 시험조유효솔위93.9％(244/260),고우대조조84.2％(219례),차이유통계학의의(x2=12.32,P＜0.05).시험조환자결가、수포간조、동통소퇴시간분별위(2.6±0.8)d、(8.2±1.7)d、(9.2±2.5)d,균저우대조조(4.8±1.4)d,(11.3±2.2)d,(12.8±3.1)d(균P＜0.01).시험조지포시간(1.9±0.6)d여대조조(1.8±0.8)d비교,차이무통계학의의(t=0.933,P＞0.05).시험조환자후유신경통발생솔6.9％(18/260),여대조조환자후유신경통발생솔18.1％(47/260),차이유통계학의의(x2=14.787,P＜0.01). 결론 액담냉동연합아석락위편、갑고알분산편구복료효우우아석락위편、갑고알분산편구복치료,시험조구유수포간조、결가시간축단、동통소퇴쾌、후유신경통발생감소적우점.
Objective To compare the efficacy and safety of liquid nitrogen cryotherapy combined with acyclovir and mecobalamin in the treatment of herpes zoster in elderly patients.Methods 520 elderly patients with herpes zoster were randomly divided into two groups,experimental group and control group (n=260,each).Patients in experimental group were treated with liquid nitrogen cryotherapy,using liquid nitrogen cotton swab to graze the skin lesions 2-3 times per day for successive 5 days,combined with acyclovir and mecobalamin.Patients in control group were treated with acyclovir and mecobalamin.New blisters and dry skin and crust were observed and compared between the two groups on the 5th,14th,30th day after treatment.The skin lesion situation and reaction times for pain complete remission,vesicular scab,postherpetic neuralgia (PHN) were recorded and analyzed.Results The effective rate was 93.9％ (244/260) in the experimental group versus 84.2％ (219/260) in the control group (x2 =12.32,P＜ 0.05).The reaction times for vesicular scab,pain complete remission and subside were shorter in experimental group than in control group [(2.63 ±0.78)d vs.(4.75±1.39)d,(8.17±1.68)d vs.(11.25±2.23)d,(9.24±2.53)d vs.(12.78±3.13)d,all P＜0.01].There was no significant difference in new blister time between the experimental group and the control group [(1.85±0.62) d vs.(1.79±0.83)d,P＞0.05].Postherpetic neuralgia incidence was lower in experimental group than in control group [6.9％ (18/260) vs.18.1％ (47/260),x2 =14.79,P＜0.01].Conclusions Treatment with liquid nitrogen cryotherapy combined with acyclovir and mecobalamin can shorten the reaction times of vesicular scab,and pain complete remission and subside,and reduce postherpetic neuralgia as compared to acyclovir and mecobalamin treatment in elderly patients with herpes zoster.
