CAJ | 학술논문

目的研究缺血修饰白蛋白(IMA)水平对预测前循环短暂性脑缺血发作(TIA)患者继发脑梗死的价值. 方法回顾性研究105例3h内人院的前循环TIA患者3h内、6h及12 h IMA水平并结合ABCD2评分,分析其与前循环TIA后继发脑梗死的相关性. 结果 3h内IMA为75.28 U/L时,诊断前循环TIA的敏感度为66.7％,特异性为76.2％.105例患者7d内继发脑梗死患者16例(15.2％),8～30 d内继发脑梗死21例(20.0％).前循环TIA患者3h内、6h及12h的IMA平均水平为(87.43±19.89) U/L、(63.88±12.51) U/L、(61.21±12.28) U/L,Pearson-Correlation分析显示3h内IMA水平与ABCD2评分呈直线相关(P=0.000,r=0.666).Kaplan-Meier生存曲线显示3h内IMA异常升高、中～高危ABCD2评分均为前循环TIA发作后继发脑梗死的危险因素(P=0.012、0.041). 结论早期IMA水平的检测与ABCD2评分对预测前循环TIA患者继发脑梗死具有相似的临床价值.
목적 연구결혈수식백단백(IMA)수평대예측전순배단잠성뇌결혈발작(TIA)환자계발뇌경사적개치. 방법 회고성연구105례3h내인원적전순배TIA환자3h내、6h급12 h IMA수평병결합ABCD2평분,분석기여전순배TIA후계발뇌경사적상관성. 결과 3h내IMA위75.28 U/L시,진단전순배TIA적민감도위66.7％,특이성위76.2％.105례환자7d내계발뇌경사환자16례(15.2％),8～30 d내계발뇌경사21례(20.0％).전순배TIA환자3h내、6h급12h적IMA평균수평위(87.43±19.89) U/L、(63.88±12.51) U/L、(61.21±12.28) U/L,Pearson-Correlation분석현시3h내IMA수평여ABCD2평분정직선상관(P=0.000,r=0.666).Kaplan-Meier생존곡선현시3h내IMA이상승고、중～고위ABCD2평분균위전순배TIA발작후계발뇌경사적위험인소(P=0.012、0.041). 결론 조기IMA수평적검측여ABCD2평분대예측전순배TIA환자계발뇌경사구유상사적림상개치.
Objective To predict a value of ischemia modified albumin (IMA) levels for assessing secondary cerebral infarction in patients with transient ischemic attack (TIA) in anterior circulation.Methods 105 patients with TIA in anterior circulation admitted to the hospital within 3 hours were retrospectively studied.Combined with ABCD2 score,the correlations of IMA levels at 3 h,6 h and 12 h with secondary cerebral infarction after anterior circulation TIA were analyzed.Results IMA level was 75.28 u/L within 3h after TIA,and the sensitivity and specificity of TIA in anterior circulation were 66.7％ and 76.2％ respectively.In the total of 105 patients,16 cases (15.2％) suffered from secondary cerebral infarction within 7d,and 21 cases (20.0％) within 8～30d.The serum IMA levels were (87.43±19.89)U/L,(63.88±12.51)U/L and (61.21±12.28)U/L at 3h,6h and 12h after TIA,respectively.A simple analysis showed that there was a linear correlation between the IMA level and ABCD2 scores (P=0.000,r=0.666).Kaplan-Meier survival curve analysis showed that the increased IMA level within 3h,and moderate to high ABCD2 score were the risk factors for secondary cerebral infarction after TIA in anterior circulation (P=0.012,0.041).Conclusions Early detection of IMA has a clinical value similar to ABCD2 score to predict secondary cerebral infarction in patients with TIA in anterior circulation.