中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2014年
8期
871-873
,共3页
应利君%吕铁%李智鑫%陆地
應利君%呂鐵%李智鑫%陸地
응리군%려철%리지흠%륙지
肺炎%呼吸机相关性%氨溴索
肺炎%呼吸機相關性%氨溴索
폐염%호흡궤상관성%안추색
Pneumonia,ventilator-associated%Ambroxol
目的 探讨静脉滴注氨溴索联合振动排痰机治疗呼吸机相关性肺炎(VAP)的临床疗效. 方法 选取本院重症医学科中行机械通气合并VAP患者96例,随机分为3组,每组32例.3组均予抗炎、吸痰、气道湿化、营养支持等常规治疗,对照组只接受常规治疗,氨溴索组在常规治疗基础上,辅以氨溴索30 mg加入生理盐水100 ml静脉滴注,3次/d,氨溴索+排痰机组在氨溴索治疗基础上隔天采用美国G5振动排痰机行叩振排痰2次/d. 结果 3组患者在治疗前后急性生理学及慢性健康状况评分系统(APACHEⅡ)(F=5.736,P＜0.05)、氧合指数(PaO2)/FiO2(F=9.432,P＜0.05)、呼吸频率(F=6.361,P＜0.05)和心率(F=5.862,P＜0.05)值比较差异均有统计学意义.治疗后,上述各项指标APACHEⅡ(F=4.674,P＜0.05)、PaO2/FiO2(F=8.665,P＜0.05)、呼吸频率(F=7.351,P＜0.05)和心率(F=6.562,P＜0.05)组间两两比较差异均有统计学意义.治疗后3组临床有效率分别为71.9％、84.4％、93.8％,组间两两比较差异均有统计学意义(P＜0.05). 结论 盐酸氨溴索静脉滴注联合振动排痰机治疗VAP效果显著,明显优于单一应用氨溴索静脉滴注.
目的 探討靜脈滴註氨溴索聯閤振動排痰機治療呼吸機相關性肺炎(VAP)的臨床療效. 方法 選取本院重癥醫學科中行機械通氣閤併VAP患者96例,隨機分為3組,每組32例.3組均予抗炎、吸痰、氣道濕化、營養支持等常規治療,對照組隻接受常規治療,氨溴索組在常規治療基礎上,輔以氨溴索30 mg加入生理鹽水100 ml靜脈滴註,3次/d,氨溴索+排痰機組在氨溴索治療基礎上隔天採用美國G5振動排痰機行叩振排痰2次/d. 結果 3組患者在治療前後急性生理學及慢性健康狀況評分繫統(APACHEⅡ)(F=5.736,P＜0.05)、氧閤指數(PaO2)/FiO2(F=9.432,P＜0.05)、呼吸頻率(F=6.361,P＜0.05)和心率(F=5.862,P＜0.05)值比較差異均有統計學意義.治療後,上述各項指標APACHEⅡ(F=4.674,P＜0.05)、PaO2/FiO2(F=8.665,P＜0.05)、呼吸頻率(F=7.351,P＜0.05)和心率(F=6.562,P＜0.05)組間兩兩比較差異均有統計學意義.治療後3組臨床有效率分彆為71.9％、84.4％、93.8％,組間兩兩比較差異均有統計學意義(P＜0.05). 結論 鹽痠氨溴索靜脈滴註聯閤振動排痰機治療VAP效果顯著,明顯優于單一應用氨溴索靜脈滴註.
목적 탐토정맥적주안추색연합진동배담궤치료호흡궤상관성폐염(VAP)적림상료효. 방법 선취본원중증의학과중행궤계통기합병VAP환자96례,수궤분위3조,매조32례.3조균여항염、흡담、기도습화、영양지지등상규치료,대조조지접수상규치료,안추색조재상규치료기출상,보이안추색30 mg가입생리염수100 ml정맥적주,3차/d,안추색+배담궤조재안추색치료기출상격천채용미국G5진동배담궤행고진배담2차/d. 결과 3조환자재치료전후급성생이학급만성건강상황평분계통(APACHEⅡ)(F=5.736,P＜0.05)、양합지수(PaO2)/FiO2(F=9.432,P＜0.05)、호흡빈솔(F=6.361,P＜0.05)화심솔(F=5.862,P＜0.05)치비교차이균유통계학의의.치료후,상술각항지표APACHEⅡ(F=4.674,P＜0.05)、PaO2/FiO2(F=8.665,P＜0.05)、호흡빈솔(F=7.351,P＜0.05)화심솔(F=6.562,P＜0.05)조간량량비교차이균유통계학의의.치료후3조림상유효솔분별위71.9％、84.4％、93.8％,조간량량비교차이균유통계학의의(P＜0.05). 결론 염산안추색정맥적주연합진동배담궤치료VAP효과현저,명현우우단일응용안추색정맥적주.
Objective To investigate the clinical efficacy of combination therapy of ambroxol with vibration? expectoration machine on ventilator-associated pneumonia Methods A total of 96 patients from the Department of Critical Care Medicine were selected and randomly divided into 3 groups:control group,ambroxol group and ammonia ambroxol + vibration expectoration machine group (n=32,each).The ventilator-associated pneumonia (VAP) was randomly divided into three groups (n =32,each).All patients were treated with conventional therapy including anti-inflammatory,suction,airway humidification,nutritional support.On this basis,ambroxol group was given ambroxol 30 mg in 100 ml normal saline,intravenously dripped 3 times a day.On the basis of treatment in the ambroxol group,ammonia ambroxol + expectoration machine were given G5 vibration expectoration machine to expectorate sputum 2 times every other day.Results There were significant differences in acute physiology and chronic health evaluation (APACHE Ⅱ),PaO2/FiO2,respiratory rate (RR),heart rate (HR) before versus after the treatment of the three groups (F =5.736,9.432,6.361,5.862,respectively,all P＜0.05).After treatment in the three groups,APACHE Ⅱ,PaO2/FiO2,RR and HR showed statistically significant differences inter-group among three groups (F=4.674,8.665,7.351,6.562,respectively,all P＜0.05).Clinical effective rates of the three groups were 71.9％,84.4％,93.8％ respectively,and showed statistically significant differences inter-group among three groups (all P＜0.05).Conclusions Combination therapy of ambroxol and vibration expectoration machine shows significant effects on VAP,and it is better than ambroxol alone.
