CAJ | 학술논문

目的评价动态血糖监测联合胰岛素泵治疗初诊老年2型糖尿病患者的临床疗效及胰岛细胞功能的恢复情况. 方法将初诊为2型糖尿病的老年患者300例,随机分为治疗组和对照组各150例,随访治疗3个月.观察并比较两组治疗前后体质指数、糖化血红蛋白、空腹血糖、餐后2h血糖、空腹胰岛素、餐后2h胰岛素、空腹C肽、餐后2hC肽等各项指标变化,以及治疗后摆脱胰岛素单纯口服降糖药即能良好控制血糖者的比例. 结果治疗后两组上述指标均较治疗前显著下降(P＜0.05),治疗组与对照组比较,能更好地改善血糖谱(P＜0.05),摆脱胰岛素即单纯口服降糖药能良好控制血糖者比例治疗组显著高于对照组(21％比3％,x2=22.475,P＜0.05). 结论动态血糖监测联合胰岛素泵治疗初诊老年2型糖尿病患者临床疗效确切,有助于改善胰岛β细胞功能,值得临床推广应用.
목적 평개동태혈당감측연합이도소빙치료초진노년2형당뇨병환자적림상료효급이도세포공능적회복정황. 방법 장초진위2형당뇨병적노년환자300례,수궤분위치료조화대조조각150례,수방치료3개월.관찰병비교량조치료전후체질지수、당화혈홍단백、공복혈당、찬후2h혈당、공복이도소、찬후2h이도소、공복C태、찬후2hC태등각항지표변화,이급치료후파탈이도소단순구복강당약즉능량호공제혈당자적비례. 결과 치료후량조상술지표균교치료전현저하강(P＜0.05),치료조여대조조비교,능경호지개선혈당보(P＜0.05),파탈이도소즉단순구복강당약능량호공제혈당자비례치료조현저고우대조조(21％비3％,x2=22.475,P＜0.05). 결론 동태혈당감측연합이도소빙치료초진노년2형당뇨병환자림상료효학절,유조우개선이도β세포공능,치득림상추엄응용.
Objective To evaluate islet cells functional recovery and clinical effects of dynamic blood sugar monitoring combined with insulin pump in newly diagnosed type 2 diabetes mellitus in the elderly.Methods 300 cases with newly diagnosed type 2 diabetes mellitus were randomly divided into treatment group (n=150) and control group (n=150) accompanying with three months follow-up.Body mass indexes (BMI),levels of hemoglobin A1c (HbA1c),fasting plasma glucose (FPG),2-h postprandial blood glucose,fasting insulin,2-h postprandial insulin,fasting C-peptide,2-h postprandial C peptide,and the percentage of patients who took oral hypoglycemic drugs alone without insulin could well control the blood glucose were compared between the two groups before versus after treatment.Results The levels of BMI,HbA1c,FPG,2-h postprandial blood glucose,fasting insulin,2-h postprandial insulin,fasting C peptide,2-h postprandial C peptide in the two groups were significantly decreased after treatment as compared with the pretreatment (P ＜ 0.05).The improvement of blood sugar spectrum was better in treatment group than in control group(P＜0.05) and the percentage of patients who took oral hypoglycemic drugs alone without insulin could well control the blood glucose was significantly higher in treatment group than in control group(21％ vs.3％,x2 =22.475,P＜0.05).Conclusions The clinical effects of dynamic blood sugar monitoring combined with insulin pump on newly diagnosed type 2 diabetes mellitus in the elderly is definite and can improve the recovery of islet cells function.It is worthy of clinical promotion.