声刺激%诱发电位,听觉
聲刺激%誘髮電位,聽覺
성자격%유발전위,은각
Acoustic stimulation%Evoked potentials,auditory
目的 探讨健康成年人随增龄听觉诱发相关电位(AERPs)的变化特征,分析AERPs与年龄的相关性,为临床诊断随增龄的认知相关疾病提供依据. 方法 对健康成年人按青年组、中年组和老年组各30例进行听觉靶/非靶刺激序列(oddball模式)AERPS检测,测量Cz点记录的P50、N100和P200波的潜伏期和波幅,Pz点记录的N200和P300波的潜伏期和波幅,分析上述指标与年龄的相关性. 结果 3组组间反应时比较差异无统计学意义,分别为青年组(519.33±33.65)ms、中年组(521.52±39.81)ms和老年组(531.46±43.26) ms(F=1.89,P=0.107).与青年组比较,中年组P50波幅增大[(2.03±0.31)μV比(1.83±0.23)μV,t=2.17,P=0.032],P300潜伏期延长[(343.17±30.70)ms比(323.54±24.56)ms,t=2.23,P=0.028],P300波幅降低[(13.88±3.15)μV比(15.62上2.12)μV,t＝2.35,P＝0.018],差异有统计学意义;与中年组比较,老年组P50波幅增大[(2.39±0.40)μV比(2.03±0.31)μV,t=4.73,P=0.000],N200潜伏期延长[(222.16±29.40)ms比(206.04±28.98)ms,t=2.12,P=0.039],P300潜伏期延长,波幅降低[(373.83±45.90) ms比(343.17±30.70)ms,t=5.12,P=0.000;(10.68±4.16) μV比(13.88±3.15)μV,t=4.95,P=0.000],差异有统计学意义;其余各波潜伏期和波幅比较差异均无统计学意义(均P＞0.05).以所有受试者为研究对象结果显示,P50波幅、P300潜伏期均与年龄呈正相关(r=0.67、0.64,均P＝0.000);青年组、中年组和老年组P50波幅年平均增长速度分别为0.008 μV/年、0.012 μV/年和0.016 μV/年,P300潜伏期年平均增长速度分别为0.917 ms/年、1.148 ms/年和1.715 ms/年. 结论 健康成年人AERPs的P50波幅和P300潜伏期与年龄相关,且随增龄P50波幅逐渐增高,P300潜伏期逐渐变长,在老年人中呈加速变化.
目的 探討健康成年人隨增齡聽覺誘髮相關電位(AERPs)的變化特徵,分析AERPs與年齡的相關性,為臨床診斷隨增齡的認知相關疾病提供依據. 方法 對健康成年人按青年組、中年組和老年組各30例進行聽覺靶/非靶刺激序列(oddball模式)AERPS檢測,測量Cz點記錄的P50、N100和P200波的潛伏期和波幅,Pz點記錄的N200和P300波的潛伏期和波幅,分析上述指標與年齡的相關性. 結果 3組組間反應時比較差異無統計學意義,分彆為青年組(519.33±33.65)ms、中年組(521.52±39.81)ms和老年組(531.46±43.26) ms(F=1.89,P=0.107).與青年組比較,中年組P50波幅增大[(2.03±0.31)μV比(1.83±0.23)μV,t=2.17,P=0.032],P300潛伏期延長[(343.17±30.70)ms比(323.54±24.56)ms,t=2.23,P=0.028],P300波幅降低[(13.88±3.15)μV比(15.62上2.12)μV,t＝2.35,P＝0.018],差異有統計學意義;與中年組比較,老年組P50波幅增大[(2.39±0.40)μV比(2.03±0.31)μV,t=4.73,P=0.000],N200潛伏期延長[(222.16±29.40)ms比(206.04±28.98)ms,t=2.12,P=0.039],P300潛伏期延長,波幅降低[(373.83±45.90) ms比(343.17±30.70)ms,t=5.12,P=0.000;(10.68±4.16) μV比(13.88±3.15)μV,t=4.95,P=0.000],差異有統計學意義;其餘各波潛伏期和波幅比較差異均無統計學意義(均P＞0.05).以所有受試者為研究對象結果顯示,P50波幅、P300潛伏期均與年齡呈正相關(r=0.67、0.64,均P＝0.000);青年組、中年組和老年組P50波幅年平均增長速度分彆為0.008 μV/年、0.012 μV/年和0.016 μV/年,P300潛伏期年平均增長速度分彆為0.917 ms/年、1.148 ms/年和1.715 ms/年. 結論 健康成年人AERPs的P50波幅和P300潛伏期與年齡相關,且隨增齡P50波幅逐漸增高,P300潛伏期逐漸變長,在老年人中呈加速變化.
목적 탐토건강성년인수증령은각유발상관전위(AERPs)적변화특정,분석AERPs여년령적상관성,위림상진단수증령적인지상관질병제공의거. 방법 대건강성년인안청년조、중년조화노년조각30례진행은각파/비파자격서렬(oddball모식)AERPS검측,측량Cz점기록적P50、N100화P200파적잠복기화파폭,Pz점기록적N200화P300파적잠복기화파폭,분석상술지표여년령적상관성. 결과 3조조간반응시비교차이무통계학의의,분별위청년조(519.33±33.65)ms、중년조(521.52±39.81)ms화노년조(531.46±43.26) ms(F=1.89,P=0.107).여청년조비교,중년조P50파폭증대[(2.03±0.31)μV비(1.83±0.23)μV,t=2.17,P=0.032],P300잠복기연장[(343.17±30.70)ms비(323.54±24.56)ms,t=2.23,P=0.028],P300파폭강저[(13.88±3.15)μV비(15.62상2.12)μV,t＝2.35,P＝0.018],차이유통계학의의;여중년조비교,노년조P50파폭증대[(2.39±0.40)μV비(2.03±0.31)μV,t=4.73,P=0.000],N200잠복기연장[(222.16±29.40)ms비(206.04±28.98)ms,t=2.12,P=0.039],P300잠복기연장,파폭강저[(373.83±45.90) ms비(343.17±30.70)ms,t=5.12,P=0.000;(10.68±4.16) μV비(13.88±3.15)μV,t=4.95,P=0.000],차이유통계학의의;기여각파잠복기화파폭비교차이균무통계학의의(균P＞0.05).이소유수시자위연구대상결과현시,P50파폭、P300잠복기균여년령정정상관(r=0.67、0.64,균P＝0.000);청년조、중년조화노년조P50파폭년평균증장속도분별위0.008 μV/년、0.012 μV/년화0.016 μV/년,P300잠복기년평균증장속도분별위0.917 ms/년、1.148 ms/년화1.715 ms/년. 결론 건강성년인AERPs적P50파폭화P300잠복기여년령상관,차수증령P50파폭축점증고,P300잠복기축점변장,재노년인중정가속변화.
Objective To investigate the relationship between auditory event-related potentials to an oddball task and age in healthy adults,in order to provide the basis for the clinical diagnosis of age-related cognitive diseases.Methods 90 subjects were examined by auditory event-related potentials to an oddball task,and divided into normal young adults,middle-aged and elderly groups (n =30,each group).We measured the wave latencies and amplitude of P50,N100 and P200 wave recorded at the Cz points,and those of N200 and P300 wave at the Pz point.The correlations of the above indicators with age were analyzed.Results The reaction times were (519.33±33.65) ms in youth group,(521.52±39.81) ms in middle age group and (531.46±43.26) ms in elderly group.There were no statistically differences in reaction times among the 3 groups(F=1.89,P=0.107).Compared with the youth group,P50 amplitudes were increased [(2.03±0.31) μV vs.(1.83±0.23) μV,t=2.17,P＝ 0.032],P300 latencies were prolonged [(343.17 ± 30.70) ms vs.(323.54 ± 24.56) ms,t=2.23,P=0.028],P300 amplitudes were decreased [(13.88±3.15) μV vs.(15.62± 2.12) μV,t=2.35,P＝0.018] in the middlc-aged group.Compared with the middle-aged group,the elderly group showed that P50 amplitudes were increased [(2.39±0.40) μV vs.(2.03±0.31) μV,t =4.73,P=0.000],N200latencies were prolonged [(222.16±29.40) ms vs.(206.04±28.98) ms,t=2.12,P=0.039],P300 latencies were prolonged and amplitudes were decreased [(373.83 ± 45.90)ms vs.(343.17±30.70)ms,t=5.12,P=0.000; (10.68±4.16)μV vs.(13.88±3.15) μV,t=4.95,P=0.000].Other waves had no significant differences in latencies and amplitudes among the three groups (all P＞ 0.05).In all subjects,P50 amplitudes and P300 latencies showed positively correlated with age.The average increments of P50 amplitudes and P300 latencies in normal young adults,middle-aged and elderly groups were 0.008 V/year,0.012 V/year and 0.016 V/year,and 0.917 ms/year,1.148 ms/year and 1.715 ms/year respectively.Conclusions In healthy adults,P50 amplitude and P300 latency of auditory event-related potentials are related with age.P50 amplitude and P300 latency are gradually increased or prolonged along with age,with accelerated changes in the elderly.
