中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2014年
11期
1235-1237
,共3页
沈莹%陈正昕%金卫东%马永春%王伟
瀋瑩%陳正昕%金衛東%馬永春%王偉
침형%진정흔%금위동%마영춘%왕위
抑郁症%Meta分析
抑鬱癥%Meta分析
억욱증%Meta분석
Depressive disorder%Meta-analysis
目的 分析老年抑郁症患者P300潜伏期和波幅的变化. 方法 在中国生物医学文献数据库(CBM)以及中文科技期刊全文数据库(CNKI)进行检索,同时联合手工检索对国内发表的13项符合本研究标准的文献应用RenMan4.1进行Meta分析. 结果 老年抑郁症患者与老年健康对照组P300的潜伏期比较,抑郁症组患者N1、P2、N2和P3潜伏期比对照组显著延长[N1:加权均数差(WMD) =3.07,95％可信区间(CI):0.70～5.42,Z＝2.55,P=0.010;P2:WMD=18.41,95％CI:15.11～21.71,Z=10.93,P＜0.010;N2:WMD=25.41,95％CI:12.80～29.02,Z=13.80,P＜0.010;P3:WMD＝32.14,95％CI:24.14～34.88,Z=23.04,P＜0.010];与健康对照组比较,老年抑郁症组患者的P2、N2和P3波幅显著降低(P2:WMD=-0.83,95％CI:-1.07～-0.59,Z=6.78,P＜0.010;N2:WMD=-0.34,95％CI:-0.59～-0.08,Z=2.57,P=0.010;P3:WMD=-2.54,95％CI:-2.75～-2.33,Z=23.99,P＜0.010). 结论 老年抑郁症P300的潜伏期明显延长,波幅明显降低.
目的 分析老年抑鬱癥患者P300潛伏期和波幅的變化. 方法 在中國生物醫學文獻數據庫(CBM)以及中文科技期刊全文數據庫(CNKI)進行檢索,同時聯閤手工檢索對國內髮錶的13項符閤本研究標準的文獻應用RenMan4.1進行Meta分析. 結果 老年抑鬱癥患者與老年健康對照組P300的潛伏期比較,抑鬱癥組患者N1、P2、N2和P3潛伏期比對照組顯著延長[N1:加權均數差(WMD) =3.07,95％可信區間(CI):0.70～5.42,Z＝2.55,P=0.010;P2:WMD=18.41,95％CI:15.11～21.71,Z=10.93,P＜0.010;N2:WMD=25.41,95％CI:12.80～29.02,Z=13.80,P＜0.010;P3:WMD＝32.14,95％CI:24.14～34.88,Z=23.04,P＜0.010];與健康對照組比較,老年抑鬱癥組患者的P2、N2和P3波幅顯著降低(P2:WMD=-0.83,95％CI:-1.07～-0.59,Z=6.78,P＜0.010;N2:WMD=-0.34,95％CI:-0.59～-0.08,Z=2.57,P=0.010;P3:WMD=-2.54,95％CI:-2.75～-2.33,Z=23.99,P＜0.010). 結論 老年抑鬱癥P300的潛伏期明顯延長,波幅明顯降低.
목적 분석노년억욱증환자P300잠복기화파폭적변화. 방법 재중국생물의학문헌수거고(CBM)이급중문과기기간전문수거고(CNKI)진행검색,동시연합수공검색대국내발표적13항부합본연구표준적문헌응용RenMan4.1진행Meta분석. 결과 노년억욱증환자여노년건강대조조P300적잠복기비교,억욱증조환자N1、P2、N2화P3잠복기비대조조현저연장[N1:가권균수차(WMD) =3.07,95％가신구간(CI):0.70～5.42,Z＝2.55,P=0.010;P2:WMD=18.41,95％CI:15.11～21.71,Z=10.93,P＜0.010;N2:WMD=25.41,95％CI:12.80～29.02,Z=13.80,P＜0.010;P3:WMD＝32.14,95％CI:24.14～34.88,Z=23.04,P＜0.010];여건강대조조비교,노년억욱증조환자적P2、N2화P3파폭현저강저(P2:WMD=-0.83,95％CI:-1.07～-0.59,Z=6.78,P＜0.010;N2:WMD=-0.34,95％CI:-0.59～-0.08,Z=2.57,P=0.010;P3:WMD=-2.54,95％CI:-2.75～-2.33,Z=23.99,P＜0.010). 결론 노년억욱증P300적잠복기명현연장,파폭명현강저.
Objective To assess the latency and amplitude changes in P300 in senile patients with depression.Methods 13 domestic published study literatures meeting our criteria were searched from CBM,CNKI,and a meta-analysis on P300 latency and amplitude was performed with RenMan 4.1 soft ware.Results 1.The P300 latency in senile patients with depression was significant longer than that in senile normal controls in N1,P2,N2,P300 (N1:WMD=3.07,95 ％ CI:0.7～5.42,Z=2.55,P=0.010;P2:WMD=18.41,95％CI:15.11～21.71,Z=10.93,P＜ 0.01;N2:WMD=25.41,95％CI:12.80～29.02,Z=13.80,P＜0.01;P3:WMD=32.14,95％CI:24.14～34.88,Z=23.04,P＜0.01).2.The amplitude in senile patients with depression was significant lower than that in senile normal controls in N2,P2,P3 (P2:WMD=-0.83,95％CI:-1.07～-0.59,Z-6.78,P＜0.01; N2:WMD＝-0.34,95％CI:-0.59～-0.08,Z=2.57,P=0.01;P3:WMD=-2.54,95％CI:-2.75～-2.33,Z=23.99,P＜0.010).Conclusions P300 longer latency and lower amplitude are the statistically characterized features for senile depressive patients.
