CAJ | 학술논문

目的分析中国部分城市HIV阳性男男性行为者(MSM)中丙型肝炎病毒(HCV)感染状况及自然清除能力.方法以沈阳、北京、长沙和昆明市HIV确证阳性的MSM为研究对象,收集基本人口学资料及CD4+T细胞淋巴细胞计数、HIV病毒载量、肝脏相关生化指标等临床信息,并进行HCV抗体和HCV-RNA检测,并将HCV抗体阳性标本分为病毒自然清除(RNA-/Ab+)和慢性感染(RNA+/Ab+)两种感染状态.结果在513例HIV阳性MSM中,检出HCV抗体阳性10例(阻性率为1.94％),其中4例HCV-RNA阳性(阳性率为0.77％),除1例HCV感染者正在接受抗病毒治疗HCV核酸检测阴性外,共5例感染者能够自然清除HCV-RNA.HCV自然清除者相对于慢性感染(病毒血症)者具有较低的氨基转移酶水平和较高的CD4+T细胞淋巴细胞水平.结论目前调查地区HIV阳性的MSM中HCV感染率处于较低水平,但仍需定期监测.
목적 분석중국부분성시HIV양성남남성행위자(MSM)중병형간염병독(HCV)감염상황급자연청제능력.방법 이침양、북경、장사화곤명시HIV학증양성적MSM위연구대상,수집기본인구학자료급CD4+T세포림파세포계수、HIV병독재량、간장상관생화지표등림상신식,병진행HCV항체화HCV-RNA검측,병장HCV항체양성표본분위병독자연청제(RNA-/Ab+)화만성감염(RNA+/Ab+)량충감염상태.결과 재513례HIV양성MSM중,검출HCV항체양성10례(조성솔위1.94％),기중4례HCV-RNA양성(양성솔위0.77％),제1례HCV감염자정재접수항병독치료HCV핵산검측음성외,공5례감염자능구자연청제HCV-RNA.HCV자연청제자상대우만성감염(병독혈증)자구유교저적안기전이매수평화교고적CD4+T세포림파세포수평.결론 목전조사지구HIV양성적MSM중HCV감염솔처우교저수평,단잉수정기감측.
Objective The aim of this study was to understand the rates of infection and spontaneous clearance on hepatitis C virus (HCV) among HIV-infected men who have sex with men (MSM) in China.Methods HIV-infected MSM from Shenyang,Beijing,Changsha and Kunming were selected to take the HCV antibody and HCV-RNA tests,and then classified into ' under recovery (RNA-/Ab +) ' or being chronic (RNA +/Ab +).Information on demography,CD4 +T cell,HIV viral load and liver biochemical indicators were also collected.Results In 513 HIV-infected MSM,the positive rate of HCV antibody was 1.94％ (10/513) and the positive rate of HCV-RNA was 0.77％ (4/513).Five patients showed clearance of HCV-RNA,spontaneously.These 5 patients had low levels of both alanine transaminase (ALT) and aspartate aminotransferase (AST),and with high level of CD4 + T cells,when compared to those who were not able to clear the HCV-RNA.Conclusion Currently,the HCV infection rate was still at quite low level among the HIV-infected MSM in China.Dynamic of HIV/HCV co-infection should be monitored so as to develop suitable strategy on prevention and treatment among this population,in China.