中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2013年
4期
321-325
,共5页
黄志征%李瑛%王春%孙涛%李慧乔%孙志明%周健%巴磊%陈同
黃誌徵%李瑛%王春%孫濤%李慧喬%孫誌明%週健%巴磊%陳同
황지정%리영%왕춘%손도%리혜교%손지명%주건%파뢰%진동
脑卒中%口服避孕药%血管紧张素原%基因多态性%联合作用
腦卒中%口服避孕藥%血管緊張素原%基因多態性%聯閤作用
뇌졸중%구복피잉약%혈관긴장소원%기인다태성%연합작용
Stroke%Oral contraceptives%Angiotensinogen%Gene polymorphism%Joint effect
目的 探讨口服避孕药(OC)暴露和血管紧张素原(AGT)基因多态及其联合作用与中国女性脑卒中发病风险的关联.方法 在“女性避孕药和宫内节育器使用队列”随访的基础上前瞻性收集确诊的脑卒中新发病例,采用病例对照研究方法(按年龄和地区匹配健康对照和医院对照),应用实时荧光定量PCR(Taqman)检测其基因型.结果 (1)OC轻度升高出血型脑卒中发病风险(OR=1.83,95％CI:1.25～ 2.66).(2)A-6G的AG/GG基因型降低脑卒中发病风险(OR=0.78,95％CI:0.61 ～ 0.99)；Cl1535A的CA/AA基因型使梗塞型脑卒中风险略有降低(OR=0.62,95％CI:0.45 ～ 0.85),AA基因型则使出血型脑卒中的发病风险升高(OR=2.57,95％CI:1.03～6.42).(3)OC和AGT基因的联合作用使得出血型脑卒中的发病风险略有升高.结论 AGT基因多态性与中国女性脑卒中的发病有关,OC与AGT基因多态性之间的联合作用可能升高出血型脑卒中的发病风险.
目的 探討口服避孕藥(OC)暴露和血管緊張素原(AGT)基因多態及其聯閤作用與中國女性腦卒中髮病風險的關聯.方法 在“女性避孕藥和宮內節育器使用隊列”隨訪的基礎上前瞻性收集確診的腦卒中新髮病例,採用病例對照研究方法(按年齡和地區匹配健康對照和醫院對照),應用實時熒光定量PCR(Taqman)檢測其基因型.結果 (1)OC輕度升高齣血型腦卒中髮病風險(OR=1.83,95％CI:1.25～ 2.66).(2)A-6G的AG/GG基因型降低腦卒中髮病風險(OR=0.78,95％CI:0.61 ～ 0.99)；Cl1535A的CA/AA基因型使梗塞型腦卒中風險略有降低(OR=0.62,95％CI:0.45 ～ 0.85),AA基因型則使齣血型腦卒中的髮病風險升高(OR=2.57,95％CI:1.03～6.42).(3)OC和AGT基因的聯閤作用使得齣血型腦卒中的髮病風險略有升高.結論 AGT基因多態性與中國女性腦卒中的髮病有關,OC與AGT基因多態性之間的聯閤作用可能升高齣血型腦卒中的髮病風險.
목적 탐토구복피잉약(OC)폭로화혈관긴장소원(AGT)기인다태급기연합작용여중국녀성뇌졸중발병풍험적관련.방법 재“녀성피잉약화궁내절육기사용대렬”수방적기출상전첨성수집학진적뇌졸중신발병례,채용병례대조연구방법(안년령화지구필배건강대조화의원대조),응용실시형광정량PCR(Taqman)검측기기인형.결과 (1)OC경도승고출혈형뇌졸중발병풍험(OR=1.83,95％CI:1.25～ 2.66).(2)A-6G적AG/GG기인형강저뇌졸중발병풍험(OR=0.78,95％CI:0.61 ～ 0.99)；Cl1535A적CA/AA기인형사경새형뇌졸중풍험략유강저(OR=0.62,95％CI:0.45 ～ 0.85),AA기인형칙사출혈형뇌졸중적발병풍험승고(OR=2.57,95％CI:1.03～6.42).(3)OC화AGT기인적연합작용사득출혈형뇌졸중적발병풍험략유승고.결론 AGT기인다태성여중국녀성뇌졸중적발병유관,OC여AGT기인다태성지간적연합작용가능승고출혈형뇌졸중적발병풍험.
Objective To evaluate the associations of oral contraceptives (OC) exposure,angiotensinogen (AGT) gene polymorphism and joint effects on the risk of stroke in Chinese women.Methods On the basis of a prospective female cohort of contraceptive use,the first-ever-developed (FED) stroke cases,as well as,two sets of age-(± 3 years) and region-matched controls (including neighborhoods and hospitalized patients) were recruited.Between 1 July 2000 and 30 June 2009,a total of 453 FED stroke cases and 919 controls were recruited.Genotyping for polymorphisms of AGT gene was detected by Taqman method.Results (1) The risk of stroke gradually increased with the cumulative time of OC use in women (P＜0.0001).Compared with the non-users,the risk of hemorrhagic stroke slightly increased among those with OC use (OR=1.83,95％CI:1.25-2.66).(2)Women with AG/GG genotypes of A-6G locus or CA/AA genotypes of Cl1535A locus indicated that there was a slightly reduced risk of stroke (OR=0.78,95％ CI:0.61-0.99; OR=0.73,95％ CI:0.56-0.95).(3) Women with AA genotypes of A-20C locus and AG/GG genotypes of A-6G,when incorporated with CA/AA genotypes of Cl1535A locus with OC,it could increase the risk of hemorrhagic stroke(OR=1.99,95％CI:1.34-2.97; OR=1.84,95％CI:1.15-2.94; OR=1.73,95％CI:1.06-2.85).Conclusion The AGT gene polymorphisms showed that they did have an impact on the risk of stroke.And the joint effect between women using OC and AGT gene polymorphisms could slightly increase the risk of stroke.
