中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2013年
4期
393-395
,共3页
邵海琳%宋春青%徐东红%尚晓静%郝兆虎
邵海琳%宋春青%徐東紅%尚曉靜%郝兆虎
소해림%송춘청%서동홍%상효정%학조호
糖尿病肾病%相关因素%高尿酸
糖尿病腎病%相關因素%高尿痠
당뇨병신병%상관인소%고뇨산
Diabetic nephropathy%Relevant factors%Hyperuricemia
目的 探讨糖尿病肾病(DN)发病的相关因素.方法 选取2009-2011年天津市第四中心医院住院治疗756例2型糖尿病患者,按尿微量白蛋白排泄率(UAER)分为三组,即＜20μg/min为无DN组(A组),20 μg/min＜UAER＜200 μg/min为微量DN组(B组),≥200 μg/min为大量DN组(C组).记录患者的一般资料,检测实验室指标,用多因素logistic回归分析DN的相关因素.结果 756例2型糖尿病患者中DN患者(B组和C组)228例,患病率为30.2％.DN患者年龄、病程、DBP和SBP均显著高于无DN组(A组)(P＜0.05)；大量DN组(C组)年龄、病程、DBP和SBP分别为(64.08±11.71)岁、(14.67±7.34)年、(87.43±14.36)mm Hg、(152.45±18.48)mmHg,与微量DN组(B组)对比,差异均有统计学意义(P＜0.05)；B组空腹血糖(FPG)、TG、TC、HDL-C、尿酸(UA)、糖化血红蛋白(HbAlc)、空腹胰岛素(FINS)、空腹C肽(FCP)分别为(9.27±3.06)mmol/L、(1.98±0.37) mmol/L、(5.01±1.08) mmol/L、(1.05±0.35) mmol/L、(312.78±39.83)mmol/L、(9.33±1.47)％、(11.45±7.83) μU/ml、(509.73±132.78) pmol/L,与A组对比,差异均有统计学意义(P＜0.05)；大量DN组(C组)FPG、TG、HDL-C、UA、FINS、FCP分别为(9.29±3.12)mmol/L、(2.02±0.36) mmol/L、(1.04±0.27) mmol/L、(389.72±46.32) mmol/L、(11.09±8.29)μU/ml、(575.77±143.29) pmol/L,与A组对比,差异均有统计学意义(P＜0.05)；大量DN组(C组)与微量DN组(B组)对比,UA、FINS、FCP的差异均有统计学意义(P＜0.05).多因素logistic回归分析表明,病程、BMI、SBP、HbAlc、FPG、UA与DN的发生有关.结论 DN的发生与病程、年龄及血糖、血脂、血压、尿酸水平密切相关.
目的 探討糖尿病腎病(DN)髮病的相關因素.方法 選取2009-2011年天津市第四中心醫院住院治療756例2型糖尿病患者,按尿微量白蛋白排洩率(UAER)分為三組,即＜20μg/min為無DN組(A組),20 μg/min＜UAER＜200 μg/min為微量DN組(B組),≥200 μg/min為大量DN組(C組).記錄患者的一般資料,檢測實驗室指標,用多因素logistic迴歸分析DN的相關因素.結果 756例2型糖尿病患者中DN患者(B組和C組)228例,患病率為30.2％.DN患者年齡、病程、DBP和SBP均顯著高于無DN組(A組)(P＜0.05)；大量DN組(C組)年齡、病程、DBP和SBP分彆為(64.08±11.71)歲、(14.67±7.34)年、(87.43±14.36)mm Hg、(152.45±18.48)mmHg,與微量DN組(B組)對比,差異均有統計學意義(P＜0.05)；B組空腹血糖(FPG)、TG、TC、HDL-C、尿痠(UA)、糖化血紅蛋白(HbAlc)、空腹胰島素(FINS)、空腹C肽(FCP)分彆為(9.27±3.06)mmol/L、(1.98±0.37) mmol/L、(5.01±1.08) mmol/L、(1.05±0.35) mmol/L、(312.78±39.83)mmol/L、(9.33±1.47)％、(11.45±7.83) μU/ml、(509.73±132.78) pmol/L,與A組對比,差異均有統計學意義(P＜0.05)；大量DN組(C組)FPG、TG、HDL-C、UA、FINS、FCP分彆為(9.29±3.12)mmol/L、(2.02±0.36) mmol/L、(1.04±0.27) mmol/L、(389.72±46.32) mmol/L、(11.09±8.29)μU/ml、(575.77±143.29) pmol/L,與A組對比,差異均有統計學意義(P＜0.05)；大量DN組(C組)與微量DN組(B組)對比,UA、FINS、FCP的差異均有統計學意義(P＜0.05).多因素logistic迴歸分析錶明,病程、BMI、SBP、HbAlc、FPG、UA與DN的髮生有關.結論 DN的髮生與病程、年齡及血糖、血脂、血壓、尿痠水平密切相關.
목적 탐토당뇨병신병(DN)발병적상관인소.방법 선취2009-2011년천진시제사중심의원주원치료756례2형당뇨병환자,안뇨미량백단백배설솔(UAER)분위삼조,즉＜20μg/min위무DN조(A조),20 μg/min＜UAER＜200 μg/min위미량DN조(B조),≥200 μg/min위대량DN조(C조).기록환자적일반자료,검측실험실지표,용다인소logistic회귀분석DN적상관인소.결과 756례2형당뇨병환자중DN환자(B조화C조)228례,환병솔위30.2％.DN환자년령、병정、DBP화SBP균현저고우무DN조(A조)(P＜0.05)；대량DN조(C조)년령、병정、DBP화SBP분별위(64.08±11.71)세、(14.67±7.34)년、(87.43±14.36)mm Hg、(152.45±18.48)mmHg,여미량DN조(B조)대비,차이균유통계학의의(P＜0.05)；B조공복혈당(FPG)、TG、TC、HDL-C、뇨산(UA)、당화혈홍단백(HbAlc)、공복이도소(FINS)、공복C태(FCP)분별위(9.27±3.06)mmol/L、(1.98±0.37) mmol/L、(5.01±1.08) mmol/L、(1.05±0.35) mmol/L、(312.78±39.83)mmol/L、(9.33±1.47)％、(11.45±7.83) μU/ml、(509.73±132.78) pmol/L,여A조대비,차이균유통계학의의(P＜0.05)；대량DN조(C조)FPG、TG、HDL-C、UA、FINS、FCP분별위(9.29±3.12)mmol/L、(2.02±0.36) mmol/L、(1.04±0.27) mmol/L、(389.72±46.32) mmol/L、(11.09±8.29)μU/ml、(575.77±143.29) pmol/L,여A조대비,차이균유통계학의의(P＜0.05)；대량DN조(C조)여미량DN조(B조)대비,UA、FINS、FCP적차이균유통계학의의(P＜0.05).다인소logistic회귀분석표명,병정、BMI、SBP、HbAlc、FPG、UA여DN적발생유관.결론 DN적발생여병정、년령급혈당、혈지、혈압、뇨산수평밀절상관.
Objective To analyze the related factors regarding diabetic nephropathy (DN).Methods A total number of 756 diabetic patients from 2009 to 2011 were analyzed retrospectively.Three groups were formed according to the urinary albumin excretion rates (UAER).Patients with UAER＜20 μg/min was grouped to group A,with UAER from 20 to 200 μg/min as group B,and the others with UAER ≥200 μg/min was grouped to group C.General characteristics and laboratory parameters were then compared and related factors of DN analyzed.Results The constituent ratio of nephropathy was 30.2％ (228/756).Patient's age,duration of disease,both diastolic and systolic blood pressure of group A were significantly higher than the non-DN group (A) (P＜0.05).Patient's age,disease duration,both diastolic and systolic blood pressure of group C were (64.08± 11.71)years,(14.67± 7.34)years,(87.43 ± 14.36)mm Hg,(152.45 ± 18.48)mm Hg,respectively,with statistically significant difference (P＜0.05) between group C and group B.FPG,TG,TC,HDL-C,UA,HbAlc,FINS,FCP of group B were (9.27 ± 3.06) mmol/L,(1.98 ± 0.37) mmol/L,(5.01 ± 1.08) mmol/L,(1.05 ± 0.35) mmol/L,(312.78 ± 39.83) mmol/L,(9.33 ± 1.47)％,(11.45 ± 7.83) μU/ml,(509.73 ±132.78) pmol/L respectively,with significant difference (P＜0.05) between group B and group A.FPG,TG,HDL-C,UA,FINS,FCP of group C were (9.29 ± 3.12)mmol/L,(2.02 ± 0.36)mmol/L,(1.04 ± 0.27) mmol/L,(389.72 ± 46.32) mmol/L,(11.09 ± 8.29) μ U/ml,(575.77 ± 143.29) pmol/Lrespectively,with significant difference (P＜0.05) between group C and group A.UA,FINS,FCP were found with significant differences (P＜0.05) between group C and group B.Data from multivariate logistic regression showed that DNs were related with disease duration,BMI,systolic blood pressure,HbAlc,FPG,UA.Conclusion DN was closely related to the duration,age,blood sugar,blood lipids,blood pressure,uric acid levels of the disease.
