中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2013年
7期
725-727
,共3页
焦喆%高菡璐%李航%贾战平%李大鹏%孙冬莹%王滨有
焦喆%高菡璐%李航%賈戰平%李大鵬%孫鼕瑩%王濱有
초철%고함로%리항%가전평%리대붕%손동형%왕빈유
糖尿病前期%高尿酸血症%稳态模型胰岛素抵抗指数%相关性分析
糖尿病前期%高尿痠血癥%穩態模型胰島素牴抗指數%相關性分析
당뇨병전기%고뇨산혈증%은태모형이도소저항지수%상관성분석
Pre-diabetes mellitus%Hyperuricemia%Homeostasis model assessment-insulin resistance index%Correlation analysis
目的 探讨高尿酸血症影响糖尿病前期(PDM)的相关因素及其两者的关系.方法 在2009年2月至2010年2月哈尔滨医科大学附属第二医院未使用噻嗪类药物的20～ 75岁PDM患者中,随机抽取157例,按尿酸水平分为正常尿酸(NUA)组(81例)和高尿酸(HUA)组(76例),对两组临床资料应用t检验以及Pearson相关分析进行统计分析,比较两组间BMI、腰围身高比(WSR) 、TC、TG、HDL-C、LDL-C、稳态模型胰岛素抵抗指数(HOMA-IR)、糖化血红蛋白(HbAlc)的差异以及各指标与尿酸的相关性.结果 (1) HUA组BMI为(27.74±2.88)kg/m2、WSR为(0.55±0.41)、TC为(6.61±0.73) mmol/L、TG为(3.94±1.97)mmol/L、LDL-C为(3.60±0.45)mmol/L、HOMA-IR为(3.09±1.20),均高于NUA组,差异有统计学意义(P＜0.05);(2)PDM患者的尿酸水平与TG、TC、LDL-C及HOMA-IR呈正相关(分别为r=0.29,r=0.33,r=0.49,r=0.51,P＜0.05),与HbAlc呈负相关(r=-0.30,P＜0.05).结论 PDM患者血尿酸水平受BMI、TC、TG、LDL-C、HOMA-IR等因素影响.体内HUA状态与胰岛素抵抗密切相关,促使PDM患者进展为糖尿病,并引发血脂代谢紊乱.
目的 探討高尿痠血癥影響糖尿病前期(PDM)的相關因素及其兩者的關繫.方法 在2009年2月至2010年2月哈爾濱醫科大學附屬第二醫院未使用噻嗪類藥物的20～ 75歲PDM患者中,隨機抽取157例,按尿痠水平分為正常尿痠(NUA)組(81例)和高尿痠(HUA)組(76例),對兩組臨床資料應用t檢驗以及Pearson相關分析進行統計分析,比較兩組間BMI、腰圍身高比(WSR) 、TC、TG、HDL-C、LDL-C、穩態模型胰島素牴抗指數(HOMA-IR)、糖化血紅蛋白(HbAlc)的差異以及各指標與尿痠的相關性.結果 (1) HUA組BMI為(27.74±2.88)kg/m2、WSR為(0.55±0.41)、TC為(6.61±0.73) mmol/L、TG為(3.94±1.97)mmol/L、LDL-C為(3.60±0.45)mmol/L、HOMA-IR為(3.09±1.20),均高于NUA組,差異有統計學意義(P＜0.05);(2)PDM患者的尿痠水平與TG、TC、LDL-C及HOMA-IR呈正相關(分彆為r=0.29,r=0.33,r=0.49,r=0.51,P＜0.05),與HbAlc呈負相關(r=-0.30,P＜0.05).結論 PDM患者血尿痠水平受BMI、TC、TG、LDL-C、HOMA-IR等因素影響.體內HUA狀態與胰島素牴抗密切相關,促使PDM患者進展為糖尿病,併引髮血脂代謝紊亂.
목적 탐토고뇨산혈증영향당뇨병전기(PDM)적상관인소급기량자적관계.방법 재2009년2월지2010년2월합이빈의과대학부속제이의원미사용새진류약물적20～ 75세PDM환자중,수궤추취157례,안뇨산수평분위정상뇨산(NUA)조(81례)화고뇨산(HUA)조(76례),대량조림상자료응용t검험이급Pearson상관분석진행통계분석,비교량조간BMI、요위신고비(WSR) 、TC、TG、HDL-C、LDL-C、은태모형이도소저항지수(HOMA-IR)、당화혈홍단백(HbAlc)적차이이급각지표여뇨산적상관성.결과 (1) HUA조BMI위(27.74±2.88)kg/m2、WSR위(0.55±0.41)、TC위(6.61±0.73) mmol/L、TG위(3.94±1.97)mmol/L、LDL-C위(3.60±0.45)mmol/L、HOMA-IR위(3.09±1.20),균고우NUA조,차이유통계학의의(P＜0.05);(2)PDM환자적뇨산수평여TG、TC、LDL-C급HOMA-IR정정상관(분별위r=0.29,r=0.33,r=0.49,r=0.51,P＜0.05),여HbAlc정부상관(r=-0.30,P＜0.05).결론 PDM환자혈뇨산수평수BMI、TC、TG、LDL-C、HOMA-IR등인소영향.체내HUA상태여이도소저항밀절상관,촉사PDM환자진전위당뇨병,병인발혈지대사문란.
Objective To investigate the relationship and the influence between pre-diabetes mellitus (PDM) and hyperuricemia (HUA).Methods 157 PDM patients,aged 20 to 75 years old were selected from the Second Clinical Medical College of Harbin Medical University,from 2009 February to 2010 February and were divided into HUA group (76 cases) and NUA group (81 cases).All the patients had not been on thiazide drugs.T-test and Pearson correlation analysis were used to calculate the differences and correlation between uric acid and biochemical indicators.Results In the HUA group,BMI was (27.74 ± 2.88) kg/m2,waist to height ratio (WSR) was (0.55 ± 0.41),TC was (6.61 ± 0.73) mmol/L,TG was (3.94 ± 1.97) mmol/L,LDL-C was (3.60 ± 0.45) mmol/L and homeostasis model assessment-insulin resistance index (HOMA-IR) was (3.09± 1.20).There were significant differences noticed in BMI,TG,TC,LDL-C,HOMA-IR at higher level in the HUA group than those in the NUA group.Pre-diabetes uric acid levels were positively correlated with TG,TC,LDL-C while HOMA-1R (TG:r=0.29,TC:r=0.33,LDL-C:r=0.49,HOMA-IR:r=0.51,P＜0.05)was negatively correlated (r=－0.30,P＜0.05) with the HbAlc.Conclusion The levels of PDM uric acid might both be related with TC,TG,LDL-C and HOMA-IR.The High level of uric acid status in vivo appeared closely related to HOMA-IR,which could further promote the progress of pre-diabetic patients to diabetes and causing dyslipidemia.Our findings suggested that the levels of pre-diabetes uric acid levels should be under concern.
