中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2013年
7期
732-735
,共4页
郭锦丽%曲成毅%白帆%马俊红%柴耀凤
郭錦麗%麯成毅%白帆%馬俊紅%柴耀鳳
곽금려%곡성의%백범%마준홍%시요봉
酗酒%股骨头坏死%骨质疏松%酒精依赖性疾患识别测验%酒精依赖程度测试
酗酒%股骨頭壞死%骨質疏鬆%酒精依賴性疾患識彆測驗%酒精依賴程度測試
후주%고골두배사%골질소송%주정의뢰성질환식별측험%주정의뢰정도측시
Alcoholism%Femoral head necrosis%Osteoporosis%The Alcohol Use Disorders Identification Test%The Alcohol Use Disorders Scale
目的 探讨酗酒与股骨头坏死(ANFH)、骨质疏松(OP)的相关性.方法 采用病例对照研究,选取山西医科大学第二医院骨科201 1年2-12月门诊、病房就医符合条件的ANFH患者95例、OP患者67例作为病例组和342例创伤骨折患者为对照组,填写调查表,明确ANFH、OP的一般相关因素,并在此三组病例中筛选出长期酗酒的ANFH 18例、OP 11例、创伤骨折患者20例,进一步进行酒精依赖性疾患识别测验(AUDIT)、酒精依赖程度测试(ADS),采用方差分析、x2检验、无序多分类logistic回归分析酗酒与ANFH、OP的关系.结果 无序多分类logistic回归分析显示,以创伤骨折患者为对照组,控制其他因素后,喜饮酒者患ANFH和OP的危险性是不饮酒者的7.70倍和8.44倍；治疗中使用激素者患ANFH和OP的风险是不使用激素者的78.43倍和22.75倍.依据AUDIT,酒精性ANFH组100％为危害性饮酒和伤害性饮酒；酒精性OP组54.45％为伤害性饮酒和危害性饮酒；创伤骨折组75％为正常饮酒,筛选诊断结果的差异有统计学意义(P＜0.01).依据ADS标准,三组患者评分差异有统计学意义(P=0.03).结论 酗酒与ANFH、OP高度相关.酒精性ANFH是酒精依赖性骨疾病,酒精性OP为部分酒精依赖性骨疾病.
目的 探討酗酒與股骨頭壞死(ANFH)、骨質疏鬆(OP)的相關性.方法 採用病例對照研究,選取山西醫科大學第二醫院骨科201 1年2-12月門診、病房就醫符閤條件的ANFH患者95例、OP患者67例作為病例組和342例創傷骨摺患者為對照組,填寫調查錶,明確ANFH、OP的一般相關因素,併在此三組病例中篩選齣長期酗酒的ANFH 18例、OP 11例、創傷骨摺患者20例,進一步進行酒精依賴性疾患識彆測驗(AUDIT)、酒精依賴程度測試(ADS),採用方差分析、x2檢驗、無序多分類logistic迴歸分析酗酒與ANFH、OP的關繫.結果 無序多分類logistic迴歸分析顯示,以創傷骨摺患者為對照組,控製其他因素後,喜飲酒者患ANFH和OP的危險性是不飲酒者的7.70倍和8.44倍；治療中使用激素者患ANFH和OP的風險是不使用激素者的78.43倍和22.75倍.依據AUDIT,酒精性ANFH組100％為危害性飲酒和傷害性飲酒；酒精性OP組54.45％為傷害性飲酒和危害性飲酒；創傷骨摺組75％為正常飲酒,篩選診斷結果的差異有統計學意義(P＜0.01).依據ADS標準,三組患者評分差異有統計學意義(P=0.03).結論 酗酒與ANFH、OP高度相關.酒精性ANFH是酒精依賴性骨疾病,酒精性OP為部分酒精依賴性骨疾病.
목적 탐토후주여고골두배사(ANFH)、골질소송(OP)적상관성.방법 채용병례대조연구,선취산서의과대학제이의원골과201 1년2-12월문진、병방취의부합조건적ANFH환자95례、OP환자67례작위병례조화342례창상골절환자위대조조,전사조사표,명학ANFH、OP적일반상관인소,병재차삼조병례중사선출장기후주적ANFH 18례、OP 11례、창상골절환자20례,진일보진행주정의뢰성질환식별측험(AUDIT)、주정의뢰정도측시(ADS),채용방차분석、x2검험、무서다분류logistic회귀분석후주여ANFH、OP적관계.결과 무서다분류logistic회귀분석현시,이창상골절환자위대조조,공제기타인소후,희음주자환ANFH화OP적위험성시불음주자적7.70배화8.44배；치료중사용격소자환ANFH화OP적풍험시불사용격소자적78.43배화22.75배.의거AUDIT,주정성ANFH조100％위위해성음주화상해성음주；주정성OP조54.45％위상해성음주화위해성음주；창상골절조75％위정상음주,사선진단결과적차이유통계학의의(P＜0.01).의거ADS표준,삼조환자평분차이유통계학의의(P=0.03).결론 후주여ANFH、OP고도상관.주정성ANFH시주정의뢰성골질병,주정성OP위부분주정의뢰성골질병.
Objective To explore the relationship of alcoholism between osteoporosis or femoral head necrosis.Methods In this case-control study,we selected 95 eligible patients with femoral head necrosis and another 67 cases of osteoporosis as case group,together with 342 patients of fractures from the Second Hospital affiliated to Shanxi Medical College,from February to December 2010,as the control group.Questionnaire was used to collect general information of the patients.Through comparative analysis,related factors of femoral head,osteoporosis were defined.18 patients with alcoholic femoral head necrosis,11 patients with alcoholic osteoporosis and 20 patients with fractures were selected from the above said three groups and going through the Alcohol Use Disorders Identification Test (AUDIT) as well as the Alcohol Use Disorders Scale (ADS).Using SPSS 13.0 conducted one-way ANOVA (analysis of variance),chi-square test,categorical logistic regression analysis were used for statistical analysis.Results Results from logistic regression analysis showed that the adjusted odds ratio of those subjects who liked drinking alcohol had an incidence of femoral head necrosis or osteoporosis as 7.70 (95％ CI:1.84,32.30) and 8.44 (95％ CI:1.70,41.90),respectively.The risks of using hormone for treating femoral head necrosis or osteoporosis were 78.43 (95％CI:11.20,149.05) and 22.75 (95％CI:2.59,100.27) times than those without.Data from the AUDIT showed that:over-dose of alcohol drinking habit existed 100％ in the femoral head necrosis group while 54.45％ in the osteoporosis group,while 75 percent patients in the fractures group had normal alcohol drinking habit.Statistically significant differences appeared in the three groups (P＜0.01).Results from the ADS showed that there were statistically significant differences between the ADS scores of the three groups (F=3.68,P=0.03).Conclusion Alcohol intake did seem to be highly correlated with the incidence rates of femoral head necrosis or osteoporosis.Alcohol-related necrosis could be viewed as alcohol-dependent diseases while alcohol-related and osteoporosis could partially be recognized as alcohol-dependent disease.
