CAJ | 학술논문

目的探讨腰围水平与糖尿病前期空腹血糖受损(IFG)发病风险的关系.方法采用前瞻性队列研究方法,以参加2006-2007年度开滦集团职工健康体检的101 510名职工中空腹血糖(FPG) ＜6.1 mmol/L、无糖尿病病史、未使用降糖药物且FPG和腰围资料完整的职工作为观察队列,排除2010-2011年度未参加体检者、FPG及腰围资料缺失者,最终纳入统计分析的有效数据为52 099名,依据基线腰围测量值将观察对象分为4组,比较组间IFG的患病率.采用多因素logistic回归分析腰围增加与IFG发病风险的关系.结果 (1)肥胖组IFG患病率高于非肥胖组(10.5％vs.6.8％,P＜0.01).随着腰围水平的增加,IFG的患病率逐渐升高,第一至四分位组患病率分别为6.0％、7.1％、8.6％、11.0％；按性别分层后,男性4组的IFG患病率分别为7.0％、7.9％、9.1％和11.4％,女性分别为2.5％、4.6％、6.8％和9.8％.(2)影响IFG的多因素logistic回归分析显示,校正年龄、性别等因素后,与第一分位组比较,第二、三、四分位组均增加IFG的发病风险,OR值分别为1.03、1.15、1.30.在不同性别人群中,校正上述因素后与第一分位组比较,男性第二、三、四分位组均增加IFG的发病风险,OR值分别为1.45、1.66和2.08,女性第二、三分位组对IFG影响不再显著,但仍增加IFG的发病风险,OR值分别为1.00、1.09和1.23.结论腰围增加可加大IFG的发病风险.
목적 탐토요위수평여당뇨병전기공복혈당수손(IFG)발병풍험적관계.방법 채용전첨성대렬연구방법,이삼가2006-2007년도개란집단직공건강체검적101 510명직공중공복혈당(FPG) ＜6.1 mmol/L、무당뇨병병사、미사용강당약물차FPG화요위자료완정적직공작위관찰대렬,배제2010-2011년도미삼가체검자、FPG급요위자료결실자,최종납입통계분석적유효수거위52 099명,의거기선요위측량치장관찰대상분위4조,비교조간IFG적환병솔.채용다인소logistic회귀분석요위증가여IFG발병풍험적관계.결과 (1)비반조IFG환병솔고우비비반조(10.5％vs.6.8％,P＜0.01).수착요위수평적증가,IFG적환병솔축점승고,제일지사분위조환병솔분별위6.0％、7.1％、8.6％、11.0％；안성별분층후,남성4조적IFG환병솔분별위7.0％、7.9％、9.1％화11.4％,녀성분별위2.5％、4.6％、6.8％화9.8％.(2)영향IFG적다인소logistic회귀분석현시,교정년령、성별등인소후,여제일분위조비교,제이、삼、사분위조균증가IFG적발병풍험,OR치분별위1.03、1.15、1.30.재불동성별인군중,교정상술인소후여제일분위조비교,남성제이、삼、사분위조균증가IFG적발병풍험,OR치분별위1.45、1.66화2.08,녀성제이、삼분위조대IFG영향불재현저,단잉증가IFG적발병풍험,OR치분별위1.00、1.09화1.23.결론 요위증가가가대IFG적발병풍험.
Objective To explore the relationship between the level of waist circumference (WC) and the impaired fasting glucose (IFG)in people working for the Kailuan Enterprise.Methods A total of 101 510 subjects from the employees of Kailuan Group who took part in the health examination between 2006 to 2007,with fasting plasma glucose (FPG) ＜6.1 mmol/L,no history of diabetes,completed data on FPG and WC examination and without using hypoglycemic agents,were selected as the observation cohort.Subjects who did not participate in the health examination from 2010 to 2011 and had incomplete data were finally excluded,ended up with 52 099 subjects available for final analysis.According to the baseline WC measurements and its quartile in the health examinations during 2006 to 2007,people under observation were divided into four groups (first,second,third and the forth quartile groups).Multiple logistic regression analysis was used to test the relation between the increasing of WC and IFG.Results (1)The incidence rate of IFG in the obese group was higher than that in non-obese group (10.5％ vs.6.8％,P＜0.01),along with an increasing WC noticed in the 4 quartile groups and the incidence rates of IFG were progressively increased,being 6.0％,7.1％,8.6％ and 11.0％ respectively in the total population (7.0％,7.9％,9.1％ and 11.4％ in males,2.5％,4.6％,6.8％ and 9.8％ in females).(2) Results from the multiple logistic regression analysis showed that,when compared with the first quartile group,the second,third and fourth quartile groups had increased risks of IFG after adjustment on age,gender and other risk factors in the total population,with the OR values being 1.03,1.15 and 1.30 respectively.After adjusting the above factors in genders,we also noticed the increased risks of IFG,with the OR value being 1.45,1.66 and 2.08 in males,while 1.00,1.09 and 1.23 in females,respectively.The influence of the second and third quartile groups on IFG was not significant in females,however.Conclusion The incidence of IFG showed an increasing trend with the increase of WC.