CAJ | 학술논문

目的分析接受抗反转录病毒治疗(ART)艾滋病患者脂肪营养不良(LD)情况,探讨影响LD发生的主要因素.方法 2012年5月对261名正在接受ART的艾滋病患者进行问卷调查,收集人口学、体格测量以及ART相关临床资料,并评估身体外周部位和中心部位的脂肪变化.结果 261名艾滋病患者中147名出现LD,检出率为56.3％.LD组与非脂肪营养不良(NLD)组在年龄、性别、睡眠质量、体重以及治疗时间方面差异有统计学意义(P＜0.05).多因素logistic回归分析显示,女性患LD的风险是男性的1.894倍(95％CI:1.075～3.338)；治疗时间每增加1年,患LD风险增加1.448倍(95％CI:1.267～1.654)；睡眠质量越差的患者越容易发生LD,睡眠质量很差者患LD的风险是很好者的11.901倍(95％CI:2.701 ～ 52.441).结论 LD在接受ART的艾滋病患者中较常见,性别、治疗时间以及睡眠质量是其主要影响因素.
목적 분석접수항반전록병독치료(ART)애자병환자지방영양불량(LD)정황,탐토영향LD발생적주요인소.방법 2012년5월대261명정재접수ART적애자병환자진행문권조사,수집인구학、체격측량이급ART상관림상자료,병평고신체외주부위화중심부위적지방변화.결과 261명애자병환자중147명출현LD,검출솔위56.3％.LD조여비지방영양불량(NLD)조재년령、성별、수면질량、체중이급치료시간방면차이유통계학의의(P＜0.05).다인소logistic회귀분석현시,녀성환LD적풍험시남성적1.894배(95％CI:1.075～3.338)；치료시간매증가1년,환LD풍험증가1.448배(95％CI:1.267～1.654)；수면질량월차적환자월용역발생LD,수면질량흔차자환LD적풍험시흔호자적11.901배(95％CI:2.701 ～ 52.441).결론 LD재접수ART적애자병환자중교상견,성별、치료시간이급수면질량시기주요영향인소.
Objective To describe the distribution and related risk factors of lipodystrophy (LD) among AIDS patients treated with antiretroviral drugs.Methods A cross-sectional study was performed on 261 AIDS patients treated with antiretroviral drugs.All the subjects were followed in the Center for Disease Control and Prevention of two counties in northern Anhui province from May 25 to 30,2012.Data related to demography,physical examination,history of antiretroviral treatment,HIV plasma viral load,and CD4 +T cell count were collected.Clinical examination was based on an assessment of changes in face,legs,arms,buttocks (peripheral sites),back,chest,neck or abdomen or change in waist size (central sites) as quoted by the clinicians.Results LD was observed in 147 (56.3％) patients.The differences of age,gender,quality of sleep,weight and time of treatment between LD and non-lipodystrophy (NLD) groups were statistically significant (P＜0.05).Results from the Multivariate logistic regression analysis showed that the risk of women suffering from LD was 1.894 times ofthd males (95％CI:1.075-3.338).The risk of those with LD showed an 1.448-fold increase regarding the time of treatment for each additional year (95％CI:1.267-1.654).Patients with poor quality of sleep were prone to LD with 11.901 times more than those with good quality of sleep (95％CI:2.701-52.441).Conclusion LD was commonly observed in AIDS patients who were under antiretroviral therapy.Gender,tine of treatment and the quality of sleep appeared the main factors related to the results of observation.