中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2013年
10期
1018-1022
,共5页
罗俊一%马依彤%谢翔%杨毅宁%马翔%付真彦%李晓梅%于子翔%陈邦党
囉俊一%馬依彤%謝翔%楊毅寧%馬翔%付真彥%李曉梅%于子翔%陳邦黨
라준일%마의동%사상%양의저%마상%부진언%리효매%우자상%진방당
冠心病%细胞间黏附分子-1%单核苷酸多态性%维吾尔族
冠心病%細胞間黏附分子-1%單覈苷痠多態性%維吾爾族
관심병%세포간점부분자-1%단핵감산다태성%유오이족
Coronary heart disease%Intercellular adhesion molecule-1%Single nucleotide polymorphism%Uygur
目的 探讨细胞间黏附分子-1基因K469E位点在新疆维吾尔(维)族人群中的分布特点及与冠心病的相关性.方法 应用聚合酶链反应-限制性片段长度多态性方法对新疆地区维族245例冠心病患者和377例健康受试者细胞间黏附分子基因-1第6外显子K469E位点进行基因型分析.结果 冠心病组与对照组基因型分布均符合Hardy-Weinberg平衡(P＞0.05).冠心病组与对照组中3种基因型分布的差异有统计学意义(P=0.039),K与E等位基因分布的差异也有统计学意义(P=0.031)；在男性亚组中冠心病组与对照组3种基因型分布的差异有统计学意义(P=0.029),等位基因分布差异均有统计学意义(P=0.025)；在女性亚组中基因型及等位基因分布的差异均无统计学意义.经调整混杂因素后,logistic回归分析提示KK基因型为维族男性人群冠心病发生的危险因素(OR=2.389,95％CI:1.458～3.915,P=0.001).结论 细胞间黏附分子-1基因第6外显子K469E基因多态性和新疆维族男性冠心病的发生具有相关性,KK基因型是冠心病发生的危险因素.
目的 探討細胞間黏附分子-1基因K469E位點在新疆維吾爾(維)族人群中的分佈特點及與冠心病的相關性.方法 應用聚閤酶鏈反應-限製性片段長度多態性方法對新疆地區維族245例冠心病患者和377例健康受試者細胞間黏附分子基因-1第6外顯子K469E位點進行基因型分析.結果 冠心病組與對照組基因型分佈均符閤Hardy-Weinberg平衡(P＞0.05).冠心病組與對照組中3種基因型分佈的差異有統計學意義(P=0.039),K與E等位基因分佈的差異也有統計學意義(P=0.031)；在男性亞組中冠心病組與對照組3種基因型分佈的差異有統計學意義(P=0.029),等位基因分佈差異均有統計學意義(P=0.025)；在女性亞組中基因型及等位基因分佈的差異均無統計學意義.經調整混雜因素後,logistic迴歸分析提示KK基因型為維族男性人群冠心病髮生的危險因素(OR=2.389,95％CI:1.458～3.915,P=0.001).結論 細胞間黏附分子-1基因第6外顯子K469E基因多態性和新疆維族男性冠心病的髮生具有相關性,KK基因型是冠心病髮生的危險因素.
목적 탐토세포간점부분자-1기인K469E위점재신강유오이(유)족인군중적분포특점급여관심병적상관성.방법 응용취합매련반응-한제성편단장도다태성방법대신강지구유족245례관심병환자화377례건강수시자세포간점부분자기인-1제6외현자K469E위점진행기인형분석.결과 관심병조여대조조기인형분포균부합Hardy-Weinberg평형(P＞0.05).관심병조여대조조중3충기인형분포적차이유통계학의의(P=0.039),K여E등위기인분포적차이야유통계학의의(P=0.031)；재남성아조중관심병조여대조조3충기인형분포적차이유통계학의의(P=0.029),등위기인분포차이균유통계학의의(P=0.025)；재녀성아조중기인형급등위기인분포적차이균무통계학의의.경조정혼잡인소후,logistic회귀분석제시KK기인형위유족남성인군관심병발생적위험인소(OR=2.389,95％CI:1.458～3.915,P=0.001).결론 세포간점부분자-1기인제6외현자K469E기인다태성화신강유족남성관심병적발생구유상관성,KK기인형시관심병발생적위험인소.
Objective To explore the distribution on K469E single nucleotide polymorphism of ICAM-1 gene among people with Uygur ethnicity,in Xinjiang and to analyze the correlation between ICAM-1 gene polymorphism and coronary heart disease.Methods 245 patients with coronary heart disease patients and 377 healthy controls in Xinjiang Uygur population were studied.ICAM-1 gene K469E genotype located in exon 6 were detected by polymerase chain reaction-restricted fragments length polymorphism.Results Distribution of genotypes in the two groups appeared to be in Hardy-Weinberg equilibrium (P＞0.05).The distribution of genotypes showed significant difference between the two groups (P=0.039) and the distributions of K and E allele also presented statistically significant difference (P=0.031).Significant difference was also observed in males (P=0.029 for genotype,P=0.025 for allele) but not in females.After adjusted for confounding factors,results from logistic regression analysis indicated that KK genotype was a risk factor for CHD in Uygur male population (OR=2.389,95％ CI:1.458-3.915,P=0.001).Conclusion Genetic polymorphism of ICAM-1 K469E might increase the risk for coronary artery disease in males of Uygur patients in Xinjiang.
