CAJ | 학술논문

目的探讨过氧化物酶体增殖物激活受体(PPAR)α/δ/γ多态性及单体型与C反应蛋白(CRP)的关联,并分析单体型和体重异常的交互作用对CRP的影响.方法在“江苏省多代谢异常和代谢综合征综合防治研究队列人群”的基础上,采用单纯随机抽样方法,选取644名研究对象.应用方差和t检验,以线性回归模型分析单核苷酸多态性(SNP)基因型与CRP水平的关联.采用SNPStats软件对PPAR三个亚型SNP分别构建单体型,并分析单体型与体重异常的交互作用对CRP水平的影响.结果调整性别、年龄、血压、吸烟和饮酒等因素后,rs1800206和rs9794与CRP水平有显著关联(P＜0.05).调整相同因素后,PPARα中AVG和CVG两个单体型、PPAR5中CG单体型与CRP水平升高有关(P＜0.05)；PPARδ中CC单体型、PPARγ中CPCAC单体型与CRP水平降低有关(P＜0.05).调整相同因素后,PPARα的AVG和CVG单体型与体重异常对CRP水平有交互作用(P＜0.05).PPARδ中,CG单体型与体重异常对CRP水平有交互作用(P＜0.05).结论 PPAR多个SNP及其单体型与CRP有显著关联；PPARα/δ单体型与体重异常存在交互作用并对CRP水平产生影响.
목적 탐토과양화물매체증식물격활수체(PPAR)α/δ/γ다태성급단체형여C반응단백(CRP)적관련,병분석단체형화체중이상적교호작용대CRP적영향.방법 재“강소성다대사이상화대사종합정종합방치연구대렬인군”적기출상,채용단순수궤추양방법,선취644명연구대상.응용방차화t검험,이선성회귀모형분석단핵감산다태성(SNP)기인형여CRP수평적관련.채용SNPStats연건대PPAR삼개아형SNP분별구건단체형,병분석단체형여체중이상적교호작용대CRP수평적영향.결과 조정성별、년령、혈압、흡연화음주등인소후,rs1800206화rs9794여CRP수평유현저관련(P＜0.05).조정상동인소후,PPARα중AVG화CVG량개단체형、PPAR5중CG단체형여CRP수평승고유관(P＜0.05)；PPARδ중CC단체형、PPARγ중CPCAC단체형여CRP수평강저유관(P＜0.05).조정상동인소후,PPARα적AVG화CVG단체형여체중이상대CRP수평유교호작용(P＜0.05).PPARδ중,CG단체형여체중이상대CRP수평유교호작용(P＜0.05).결론 PPAR다개SNP급기단체형여CRP유현저관련；PPARα/δ단체형여체중이상존재교호작용병대CRP수평산생영향.
Objective To explore the roles of peroxisome proliferator-activated receptors (PPARs) on the levels of serum C-reactive protein (CRP) and the interactions of PPARs haplotypes with abnormal body weight.Methods Subjects (n=644) were randomly selected from the cohort ‘Prevention of Multiple metabolic disorders and Metabolic syndrome in Jiangsu province (PMMJS)'Variance test,t test and lineal regression were used to analyze the associations between PPARs polymorphisms and the levels of CRP.The association between PPARs haplotypes and serum CRP levels as well as the interaction of PPARs haplotypes with abnormal body weight were analyzed,under the SNPStats software.Results After adjusting for sex,age,blood pressure,cigarette smoking,alcohol drinking and so on,data showed that both rs1800206 and rs9794 were associated with the changes along with the levels of CRP (P＜0.05).After adjusting for the same factors,haplotypes of AVG and CVG in PPARα,CG in PPARδ appeared to be associated with the increase (P＜0.05) while haplotypes of CC in PPARδ,CPCAC in PPARγ were associated with the decrease of CRP levels (P＜0.05).Results from the Interaction analysis also noted that the interactions did exist between abnormal body weight and both AVG,CVG in PPARαt,and CG in PPARδ.Conclusion PPARs polymorphisms and haplotypes were associated with CRP.Interaction between PPAR α/δand abnormal body weight might contribute to the levels of CRP.