CAJ | 학술논문

目的应用Meta分析方法评价洁悠神(jie you shen,JUC)长效抗菌材料防治留置导尿管伴随性尿路感染(catheter associated urinary tract infection,CAUTI)的效果.方法检索1995-2012年中国数字医院图书馆全文数据库、中国生物医学文献光盘数据库、中国知网CHKD期刊全文数据库、维普资讯中文科技期刊数据库等发表的有关JUC防治CAUTI的文献.制定文献纳入及排除标准,并通过查阅文献制定效应指标的评价标准.由2名研究者分别独立筛选文献,符合纳入标准的文献应用ReviewManager 4.2软件进行Meta分析,计算治疗组与对照组感染率的危险率差(RD)及95％ CI.对不能进行Meta分析的文献进行描述性分析,客观评价JUC防治CAUTI的疗效.结果共检索到相关文献20篇,其中多中心随机对照研究1篇,单中心随机研究18篇,无对照的临床病例观察1篇.共纳入患者3172例,其中对照组1526例,治疗组1646例,治疗组采用常规护理基础上加用JUC防治,对照组采用常规护理.评价结果显示治疗组感染率为(6.9±6.5)％,对照组为(27.9±13.7)％,治疗组与对照组的RD为-0.15(95％CI:-0.18～-0.13),治疗组感染率显著低于对照组,差异有统计学意义(P＜0.05).结论 JUC长效抗菌材料能有效的降低CAUTI发生率.
목적 응용Meta분석방법평개길유신(jie you shen,JUC)장효항균재료방치류치도뇨관반수성뇨로감염(catheter associated urinary tract infection,CAUTI)적효과.방법 검색1995-2012년중국수자의원도서관전문수거고、중국생물의학문헌광반수거고、중국지망CHKD기간전문수거고、유보자신중문과기기간수거고등발표적유관JUC방치CAUTI적문헌.제정문헌납입급배제표준,병통과사열문헌제정효응지표적평개표준.유2명연구자분별독립사선문헌,부합납입표준적문헌응용ReviewManager 4.2연건진행Meta분석,계산치료조여대조조감염솔적위험솔차(RD)급95％ CI.대불능진행Meta분석적문헌진행묘술성분석,객관평개JUC방치CAUTI적료효.결과 공검색도상관문헌20편,기중다중심수궤대조연구1편,단중심수궤연구18편,무대조적림상병례관찰1편.공납입환자3172례,기중대조조1526례,치료조1646례,치료조채용상규호리기출상가용JUC방치,대조조채용상규호리.평개결과현시치료조감염솔위(6.9±6.5)％,대조조위(27.9±13.7)％,치료조여대조조적RD위-0.15(95％CI:-0.18～-0.13),치료조감염솔현저저우대조조,차이유통계학의의(P＜0.05).결론 JUC장효항균재료능유효적강저CAUTI발생솔.
Objective The prevention effect of CAUTI by long-acting antibacterial material JUC was evaluated by meta analysis.Methods China digital hospital library full-text database,Chinese biomedical literature CD database,China hosptial knowledge database (CHKD) in China national knowledge internet (CNKI),VIP information Chinese science and technology periodical database were retrieved to fully collect the literature from 1995 to 2012 regarding JUC's prevention effect of CAUTI.The inclusion and exclusion standard of literature was made,and the effect index was made from the literature.Two researchers collected the literatures independently,and the included literatures were meta-analyzed by Review Manager 4.2 software,and the risk difference of infection rate and 95％ CI were calculated in both the treatment group and control group.Those literatures which could not be meta-analyzed were performed descriptive analysis to evaluate the efficacy of JUC objectively.Results 20 related articles were retrieved,including 1 multicenter randomized control study,18 monocentric randomized control studies,and 1 uncontrolled study.3172 cases were included with 1526 cases in control group (usual care) and 1646 cases in treatment group (usual care with JUC).The difference between the two groups is significant (RD =-0.15,95％ CI:-0.18 ～-0.13,P ＜ 0.05).Conclusions Long-acting antibacterial material JUC can diminish the incidence of CAUTI significantly.