中华泌尿外科杂志
中華泌尿外科雜誌
중화비뇨외과잡지
CHINESE JOURNAL OF UROLOGY
2013年
3期
208-211
,共4页
良性前列腺增生%代谢综合征%前列腺体积%前列腺特异性抗原
良性前列腺增生%代謝綜閤徵%前列腺體積%前列腺特異性抗原
량성전렬선증생%대사종합정%전렬선체적%전렬선특이성항원
Benign prostatic hyperplasia%Metabolic syndrome%Prostate volume%Prostate specific antigen
目的 探讨BPH与血生化代谢指标的关系. 方法 回顾性分析2008年1月至2010年10月收治的73例术后病理确诊为BPH的患者资料.年龄55 ～86岁,平均70岁.其中术前3个月内未服用影响血糖、血脂等代谢水平药物的患者65例,分析患者前列腺总体积、年均增长率与血糖、血脂、血前列腺特异性抗原(PSA)之间的关系.73例患者按有无合并代谢综合征(MS)分为两组,比较两组间前列腺总体积、年均增长率、血PSA等临床指标. 结果 65例BPH患者前列腺总体积为(58.76±25.96) ml,年均增长率为(1.32±0.89)ml,空腹血糖为(4.99±0.73) mmol/L,高密度脂蛋白为(1.36±0.39) mmol/L,血tPSA值为(5.99 ±8.30)μg/L.按患者前列腺总体积分组后统计分析显示空腹血糖(F=4.63,P=0.0060)、血tPSA值(F=4.83,P=0.0044)、体积年均增长率(F=62.98,P=0.0001)随前列腺总体积增加而升高,而高密度脂蛋白降低(F=5.32,P=0.0025).对前列腺总体积控制后仍显示前列腺总体积与空腹血糖呈正相关(r =0.48,P=0.0005),与高密度脂蛋白呈负相关(r=-0.26,P=0.0353).73例患者中合并MS者20例,血tPSA(6.52±5.28) μg/L、前列腺总体积(79.41±38.24) ml、年均增长率(1.86±1.14)ml,无合并MS者分别为(3.95±3.77) μg/L、(54.98±20.94)ml及(1.23 ±0.80) ml,组间差异均有统计学意义(t=2.29,P=0.0253；t =2.65,P=0.0147；t=2.22,P=0.0360). 结论 BPH患者前列腺总体积及年均增长率、血tPSA与血糖、血脂等代谢水平有关,与空腹血糖呈正相关,与高密度脂蛋白呈负相关.合并MS者前列腺临床进展特性更明显.
目的 探討BPH與血生化代謝指標的關繫. 方法 迴顧性分析2008年1月至2010年10月收治的73例術後病理確診為BPH的患者資料.年齡55 ～86歲,平均70歲.其中術前3箇月內未服用影響血糖、血脂等代謝水平藥物的患者65例,分析患者前列腺總體積、年均增長率與血糖、血脂、血前列腺特異性抗原(PSA)之間的關繫.73例患者按有無閤併代謝綜閤徵(MS)分為兩組,比較兩組間前列腺總體積、年均增長率、血PSA等臨床指標. 結果 65例BPH患者前列腺總體積為(58.76±25.96) ml,年均增長率為(1.32±0.89)ml,空腹血糖為(4.99±0.73) mmol/L,高密度脂蛋白為(1.36±0.39) mmol/L,血tPSA值為(5.99 ±8.30)μg/L.按患者前列腺總體積分組後統計分析顯示空腹血糖(F=4.63,P=0.0060)、血tPSA值(F=4.83,P=0.0044)、體積年均增長率(F=62.98,P=0.0001)隨前列腺總體積增加而升高,而高密度脂蛋白降低(F=5.32,P=0.0025).對前列腺總體積控製後仍顯示前列腺總體積與空腹血糖呈正相關(r =0.48,P=0.0005),與高密度脂蛋白呈負相關(r=-0.26,P=0.0353).73例患者中閤併MS者20例,血tPSA(6.52±5.28) μg/L、前列腺總體積(79.41±38.24) ml、年均增長率(1.86±1.14)ml,無閤併MS者分彆為(3.95±3.77) μg/L、(54.98±20.94)ml及(1.23 ±0.80) ml,組間差異均有統計學意義(t=2.29,P=0.0253；t =2.65,P=0.0147；t=2.22,P=0.0360). 結論 BPH患者前列腺總體積及年均增長率、血tPSA與血糖、血脂等代謝水平有關,與空腹血糖呈正相關,與高密度脂蛋白呈負相關.閤併MS者前列腺臨床進展特性更明顯.
목적 탐토BPH여혈생화대사지표적관계. 방법 회고성분석2008년1월지2010년10월수치적73례술후병리학진위BPH적환자자료.년령55 ～86세,평균70세.기중술전3개월내미복용영향혈당、혈지등대사수평약물적환자65례,분석환자전렬선총체적、년균증장솔여혈당、혈지、혈전렬선특이성항원(PSA)지간적관계.73례환자안유무합병대사종합정(MS)분위량조,비교량조간전렬선총체적、년균증장솔、혈PSA등림상지표. 결과 65례BPH환자전렬선총체적위(58.76±25.96) ml,년균증장솔위(1.32±0.89)ml,공복혈당위(4.99±0.73) mmol/L,고밀도지단백위(1.36±0.39) mmol/L,혈tPSA치위(5.99 ±8.30)μg/L.안환자전렬선총체적분조후통계분석현시공복혈당(F=4.63,P=0.0060)、혈tPSA치(F=4.83,P=0.0044)、체적년균증장솔(F=62.98,P=0.0001)수전렬선총체적증가이승고,이고밀도지단백강저(F=5.32,P=0.0025).대전렬선총체적공제후잉현시전렬선총체적여공복혈당정정상관(r =0.48,P=0.0005),여고밀도지단백정부상관(r=-0.26,P=0.0353).73례환자중합병MS자20례,혈tPSA(6.52±5.28) μg/L、전렬선총체적(79.41±38.24) ml、년균증장솔(1.86±1.14)ml,무합병MS자분별위(3.95±3.77) μg/L、(54.98±20.94)ml급(1.23 ±0.80) ml,조간차이균유통계학의의(t=2.29,P=0.0253；t =2.65,P=0.0147；t=2.22,P=0.0360). 결론 BPH환자전렬선총체적급년균증장솔、혈tPSA여혈당、혈지등대사수평유관,여공복혈당정정상관,여고밀도지단백정부상관.합병MS자전렬선림상진전특성경명현.
Objective To determine the relationship between blood biochemical metabolites and benign prostatic hyperplasia (BPH).Methods From Jan.2008 to Oct.2010,the medical records of 73 BPH patients diagnosed by postoperative histopathology were retrospectively studied.The age of patients ranged from 55 to 86 years.The average patient age was 70 years.Of the 73 cases,65 cases were not taking medications which could have an impact on metabolic levels of serum glucose and lipoprotein.Three months prior to operation,the patients were placed in a group to analyze the correlation between the total volume of the prostate (TP),prostate average annual growth rate and biochemical metabolites including serum glucose,high-density lipoprotein cholesterol (HDL-c) and prostate specific antigen (PSA).To compare the changes of prostate volume,prostate annual growth rate and PSA,the 73 cases were divided into two groups; patients with metabolic syndrome (MS) and those without MS.Results Of the 65 BPH patients,the mean of TP and prostate annual growth rate were (58.76 ± 25.96) ml and (1.32 ± 0.89) ml,serum glucose was (4.99 ± 0.73) mmol/L,HDL-c was (1.36 ± 0.39) mmol/L,and PSA was (5.99 ±8.30) μg/L.Stratified with prostate volume,patient's serum glucose,prostate annual growth rate and PSA levels increased with the increased TP (F =4.63,P =0.0060; F =62.98,P =0.0001 ; F =4.83,P =0.0044).On the other hand.HDL-c decreased with the increased TP (F =5.32,P =0.0025).There was a positive relationship between TP and serum glucose (r =0.48,P =0.0005).There was a negative correlation between TP and HDL-c (r =-0.26,P =0.0353).Of the 73 patients,20 cases had MS.The MS group had PSA levels (6.52 ± 5.28) μg/L,TP (79.41 ± 38.24) ml and prostate annual growth rate (1.86 ± 1.14) ml.These levels were higher than the 53 cases without MS.The group without MS had PSA levels (3.95 ± 3.77) μg/L,TP (54.98 ± 20.94) ml and prostate annual growth rate (1.23 ± 0.80) ml (t=2.29,P=0.0253; t=2.65,P=0.0147; t=2.22,P=0.0360).Conclusions PSAlevels,TP and prostate annual growth rate in BPH patients are related with blood biochemical metabolites.Both serum glucose and HDL-c affect prostate volume.BPH patients with MS have a remarkable clinical progression.
