CAJ | 학술논문

目的探讨腹股沟疝与睾丸癌发生的关联性. 方法计算机检索万方数据全文数据库、中国期刊全文数据库、维普中文科技期刊全文数据库、中国生物医学文献数据库、PubMed、荷兰《医学文摘》,并辅以参考文献的追溯,收集1979-2012年公开发表的关于腹股沟疝与睾丸癌发生的关联性研究论文.初筛获得相关文献49篇,其中中文文献6篇、英文文献43篇,选择比值比(OR)/标准化发生比(SIR)及其95％CI作为Meta分析指标.利用STATA 11.0软件对研究结果进行异质性检验和效应值合并计算. 结果根据统一的纳入和剔除标准,纳入17篇文献,其中病例对照研究文献16篇,队列研究文献1篇.16篇病例对照研究文献中,睾丸癌患者4695例,对照组6328例,其中结果显示腹股沟疝与睾丸癌的发生有关联者6篇,16篇合并OR值为1.33(95％CI 1.06～1.67),有统计学意义,有腹股沟疝者发生睾丸癌的可能性为无腹股沟疝者的1.33倍.1篇队列研究文献中腹股沟疝患者队列人数30 199例,SIR=1.1 (95％CI 0.4～2.2),无统计学意义. 结论腹股沟疝与睾丸癌的发生之间存在关联性,腹股沟疝增加睾丸癌的患病风险.
목적 탐토복고구산여고환암발생적관련성. 방법 계산궤검색만방수거전문수거고、중국기간전문수거고、유보중문과기기간전문수거고、중국생물의학문헌수거고、PubMed、하란《의학문적》,병보이삼고문헌적추소,수집1979-2012년공개발표적관우복고구산여고환암발생적관련성연구논문.초사획득상관문헌49편,기중중문문헌6편、영문문헌43편,선택비치비(OR)/표준화발생비(SIR)급기95％CI작위Meta분석지표.이용STATA 11.0연건대연구결과진행이질성검험화효응치합병계산. 결과 근거통일적납입화척제표준,납입17편문헌,기중병례대조연구문헌16편,대렬연구문헌1편.16편병례대조연구문헌중,고환암환자4695례,대조조6328례,기중결과현시복고구산여고환암적발생유관련자6편,16편합병OR치위1.33(95％CI 1.06～1.67),유통계학의의,유복고구산자발생고환암적가능성위무복고구산자적1.33배.1편대렬연구문헌중복고구산환자대렬인수30 199례,SIR=1.1 (95％CI 0.4～2.2),무통계학의의. 결론 복고구산여고환암적발생지간존재관련성,복고구산증가고환암적환병풍험.
Objective To evaluate the associations between inguinal hernia and testicular cancer.Methods A computerized search on literature was carried out in Wanfang,CNKI,VIP databases and CBM,PubMed,EMBASE databases to collect articles published between 1979 and 2012 concerning the associations between inguinal hernia and testicular cancer.There are total 49 articles,in which six articles were written in Chinese and other articles were written in English.Odds ratio (OR) and standard incidence ratio (SIR) were used to assess the strength of the association,and 95％ Confidence Interval (CI) to present the precision of the estimates.Meta-analysis was performed using the STATA (11.0) statistical software.Results We identified 16 case-control studies and one cohort studies by the uniform inclusion and exclusion criteria.Among the 16 case-control studies,six reported statistically significant positive association between inguinal hernia and testicular cancer,the others reported none statistically significant association between inguinal hernia and testicular cancer.Analysis of the 16 case-control studies that included 4695 testicular cancer patients and 6328 controls revealed an overall statistically significant association between inguinal hernia and testicular cancer (summary OR=1.33,95％CI 1.06 to 1.67).Of the one cohort study that included 30 199 inguinal hernia patients and reported SIR (1.1,0.4-2.2),there was not a statistically significant association between inguinal hernia and testicular cancer.Conclusions Our findings support a relationship between inguinal hernia and increased risk of testicular cancer.