中华泌尿外科杂志
中華泌尿外科雜誌
중화비뇨외과잡지
CHINESE JOURNAL OF UROLOGY
2014年
9期
708-711
,共4页
潘建刚%阎家骏%骆振刚%周毅
潘建剛%閻傢駿%駱振剛%週毅
반건강%염가준%락진강%주의
他达拉非%舍曲林%多沙唑嗪%早泄
他達拉非%捨麯林%多沙唑嗪%早洩
타체랍비%사곡림%다사서진%조설
Tadalafil%Sertraline%Doxazosin%Premature ejaculation
目的 比较舍曲林联合多沙唑嗪或他达拉非治疗早泄的疗效及不良反应. 方法 2011年2月至2011年8月收治的无器质性病变的早泄患者105例.年龄19～52岁,平均35岁.抽签法随机分成A、B、C组,每组35例,3组均口服舍曲林50 mg,1次/d(性生活前4～6h服用);B组加服多沙唑嗪4 mg,1次/d(性生活前8～9h服用);C组性生活前1h加服他达拉非20 mg.服药12周.A组治疗前平均阴道内射精潜伏期、患者性生活满意度评分、配偶性生活满意度评分分别为(0.6±0.1) min、(8.3±1.3)分、(5.3±1.4)分;B组分别为(0.6±0.1) min、(7.6±1.5)分、(5.6±1.5)分;C组分别为(0.6±0.1) min、(8.1±1.1)分、(5.0±1.2)分.比较3组治疗前后的平均阴道内射精潜伏期、患者性生活满意度评分及配偶性生活满意度评分的差异,治疗结束后比较3组的不良反应发生率的差异.结果 治疗12周后,A组的平均阴道内射精潜伏期、患者性生活满意度评分、配偶性生活满意度评分分别为(3.9±0.1) min、(10.6±0.1)分、(9.7±0.1)分;B组分别为(4.5±0.1)min、(12.8±1.3)分、(11.9±1.6)分;C组则分别为(5.6±0.3) min、(14.6± 1.4)分、(13.1±1.5)分,B、C组与A组比较差异均有统计学意义(P＜0.05).C组的患者性生活满意度评分、配偶性生活满意度评分高于B组,但差异无统计学意义(P＞0.05).A组9例(25.7％)、B组8例(22.9％)、C组8例(22.9％)出现恶心、胃部不适;A组5例(14.3％)、B组8例(22.9％)、C组9例(25.7％)出现头痛、头晕;C组6例(17.1％)出现潮红,A、B组各1例(2.9％)性欲下降.B、C组的不良反应发生率显著高于A组,差异有统计学意义(P＜0.05).结论 舍曲林联合他达拉菲或多沙唑嗪治疗早泄的疗效好于单用舍曲林,但不良反应发生率也稍有增加;舍曲林与他达拉非或多沙唑嗪联用治疗早泄的疗效无明显区别.
目的 比較捨麯林聯閤多沙唑嗪或他達拉非治療早洩的療效及不良反應. 方法 2011年2月至2011年8月收治的無器質性病變的早洩患者105例.年齡19～52歲,平均35歲.抽籤法隨機分成A、B、C組,每組35例,3組均口服捨麯林50 mg,1次/d(性生活前4～6h服用);B組加服多沙唑嗪4 mg,1次/d(性生活前8～9h服用);C組性生活前1h加服他達拉非20 mg.服藥12週.A組治療前平均陰道內射精潛伏期、患者性生活滿意度評分、配偶性生活滿意度評分分彆為(0.6±0.1) min、(8.3±1.3)分、(5.3±1.4)分;B組分彆為(0.6±0.1) min、(7.6±1.5)分、(5.6±1.5)分;C組分彆為(0.6±0.1) min、(8.1±1.1)分、(5.0±1.2)分.比較3組治療前後的平均陰道內射精潛伏期、患者性生活滿意度評分及配偶性生活滿意度評分的差異,治療結束後比較3組的不良反應髮生率的差異.結果 治療12週後,A組的平均陰道內射精潛伏期、患者性生活滿意度評分、配偶性生活滿意度評分分彆為(3.9±0.1) min、(10.6±0.1)分、(9.7±0.1)分;B組分彆為(4.5±0.1)min、(12.8±1.3)分、(11.9±1.6)分;C組則分彆為(5.6±0.3) min、(14.6± 1.4)分、(13.1±1.5)分,B、C組與A組比較差異均有統計學意義(P＜0.05).C組的患者性生活滿意度評分、配偶性生活滿意度評分高于B組,但差異無統計學意義(P＞0.05).A組9例(25.7％)、B組8例(22.9％)、C組8例(22.9％)齣現噁心、胃部不適;A組5例(14.3％)、B組8例(22.9％)、C組9例(25.7％)齣現頭痛、頭暈;C組6例(17.1％)齣現潮紅,A、B組各1例(2.9％)性欲下降.B、C組的不良反應髮生率顯著高于A組,差異有統計學意義(P＜0.05).結論 捨麯林聯閤他達拉菲或多沙唑嗪治療早洩的療效好于單用捨麯林,但不良反應髮生率也稍有增加;捨麯林與他達拉非或多沙唑嗪聯用治療早洩的療效無明顯區彆.
목적 비교사곡림연합다사서진혹타체랍비치료조설적료효급불량반응. 방법 2011년2월지2011년8월수치적무기질성병변적조설환자105례.년령19～52세,평균35세.추첨법수궤분성A、B、C조,매조35례,3조균구복사곡림50 mg,1차/d(성생활전4～6h복용);B조가복다사서진4 mg,1차/d(성생활전8～9h복용);C조성생활전1h가복타체랍비20 mg.복약12주.A조치료전평균음도내사정잠복기、환자성생활만의도평분、배우성생활만의도평분분별위(0.6±0.1) min、(8.3±1.3)분、(5.3±1.4)분;B조분별위(0.6±0.1) min、(7.6±1.5)분、(5.6±1.5)분;C조분별위(0.6±0.1) min、(8.1±1.1)분、(5.0±1.2)분.비교3조치료전후적평균음도내사정잠복기、환자성생활만의도평분급배우성생활만의도평분적차이,치료결속후비교3조적불량반응발생솔적차이.결과 치료12주후,A조적평균음도내사정잠복기、환자성생활만의도평분、배우성생활만의도평분분별위(3.9±0.1) min、(10.6±0.1)분、(9.7±0.1)분;B조분별위(4.5±0.1)min、(12.8±1.3)분、(11.9±1.6)분;C조칙분별위(5.6±0.3) min、(14.6± 1.4)분、(13.1±1.5)분,B、C조여A조비교차이균유통계학의의(P＜0.05).C조적환자성생활만의도평분、배우성생활만의도평분고우B조,단차이무통계학의의(P＞0.05).A조9례(25.7％)、B조8례(22.9％)、C조8례(22.9％)출현악심、위부불괄;A조5례(14.3％)、B조8례(22.9％)、C조9례(25.7％)출현두통、두훈;C조6례(17.1％)출현조홍,A、B조각1례(2.9％)성욕하강.B、C조적불량반응발생솔현저고우A조,차이유통계학의의(P＜0.05).결론 사곡림연합타체랍비혹다사서진치료조설적료효호우단용사곡림,단불량반응발생솔야초유증가;사곡림여타체랍비혹다사서진련용치료조설적료효무명현구별.
Objective To compare the efficacy and safety of sertraline plus doxazosin and tadalafil in the treatment of premature ejaculation (PE).Methods From Feb.to Aug.2011,One hundred and five patients from 19 to 52 years old with PE but without any obvious organic cause were enrolled in this study.They were randomly divided into Groups A,B and C in equal number.All the three Groups received 50 mg sertraline daily 4 to 6 hours before planned sexual activity for 12 weeks,Group B were added with 4 mg Doxazosin every day 8 to 9 hour before planned sexual activity,and Group C were given 20 mg Tadalafil as needed one hour before planned sexual activity.The mean intravaginal ejaculatory latency time,the mean intercourse satisfaction domain values and the sexual activity satisfaction domain values of the patient couples of group A before treatment were 0.6±±0.1 min,8.3±1.3,5.3±1.4; Group B were 0.6±0.1 min,7.6± 1.5,5.6± 1.5 ; Group C were 0.6±0.1 min,8.1 ± 1.1,5.0± 1.2,respectively.We observed before and after the treatment for 12 weeks and the effects were evaluated.Results The mean intravaginal ejaculatory latency time,the mean intercourse satisfaction domain values and the sexual activity satisfaction domain values of the patient couples of group A were 3.9±0.l min,10.6±0.1,9.7±0.1,respectively; Group B were 4.5 ± 0.1 min,12.8±1.3,11.9±1.6; Group C were 5.6±0.3 min,14.6±1.4,13.1±1.5,respectively.The mean intravaginal ejaculatory latency time improved in all of the 3 groups,but more significantly in Group B and C (P＜0.05).The mean intercourse satisfaction domain values of the IIEF were significantly greater in Group B and C than in Group A (P＜0.05) after the treatment; and the sexual activity satisfaction domain values of the patient couples were greater in Group C than in Group B after the treatment,but it is not significant.As for the side effects,5 cases in group A felt headaches and dizzy (14.3％),8 cases in group B felt headaches and dizzy (22.9％),and in group C,9 cases felt headaches and dizzy (25.7％),6 cases experienced flushing episodes on the body (17.1％).there was a higher rate of headaches (P＜0.05) and flushing episodes (P＜0.05) in Group B and C than in Group A.Conelusions Sertraline combined with Tadalafil or Doxazosin can achieve significantly better results than sertraline alone in patients with premature ejaculation.However,the combined treatment is associated with a slightly increased in the drug related side effects,and there is no significant difference in the efficacy of Sertraline Plus Tadalafil or Doxazosin in the treatment of premature ejaculation.
