中华泌尿外科杂志
中華泌尿外科雜誌
중화비뇨외과잡지
CHINESE JOURNAL OF UROLOGY
2014年
10期
767-770
,共4页
南玉奎%安恒庆%王峰%郑路%木拉提·热夏提%安尼瓦尔·牙生%王玉杰%张立东
南玉奎%安恆慶%王峰%鄭路%木拉提·熱夏提%安尼瓦爾·牙生%王玉傑%張立東
남옥규%안항경%왕봉%정로%목랍제·열하제%안니와이·아생%왕옥걸%장립동
前列腺特异性抗原%民族%膳食
前列腺特異性抗原%民族%膳食
전렬선특이성항원%민족%선식
Prostate specific antigen%Ethnic groups%Diet
目的 探讨新疆地区维吾尔族与汉族前列腺癌发病差异以及可能的影响因素.方法 回顾性分析2007年5月至2013年10月以下尿路症状就诊且年龄＞50岁的维吾尔族和汉族患者,患者行PSA检测、直肠指检及经腹前列腺超声、MRI检查.符合前列腺穿刺活检指征者696例,其中维吾尔族152例、汉族544例,对两组患者不同年龄tPSA、不同tPSA水平前列腺癌检出率以及病理分级进行对比分析.tPSA值以中位数(四分位间距)表示. 结果 ①696例维吾尔族、汉族前列腺穿刺患者的tPSA值为15.5 (25.9)、18.7(36.7) μg/L,按照年龄分层,50 ～ 59岁组分别为11.1(1 1.6)、11.8(17.9) μg/L,60～ 69岁组15.6(39.0)、16.5 (33.0)μg/L,70 ～ 79岁组17.4(25.1)、18.3(40.2)μg/L,≥80岁组11.7(19.4)、44.4(71.5) μg/L.前列腺穿刺患者维吾尔族各年龄组tPSA水平均低于汉族,但仅≥80岁组差异有统计学意义,其余3组差异均无统计学意义(P＞0.05).②共检出276例前列腺癌患者.维吾尔族、汉族前列腺癌检出率分别为34.2％ (52/152)、41.2％ (224/544),按照PSA分层,＜4 μg/L组分别为0(0)、29.2％(7/24),4～ 10 μg/L组16.1％ (5/31)、17.0％(18/106),＞10～ 20 μg/L组14.3％ (7/49)、19.9％ (31/156),＞20μg/L组64.5％(40/62)、65.1％(168/258).维吾尔族各tPSA水平组前列腺癌检出率均低于汉族,但差异多无统计学意义(P＞0.05).③维吾尔族、汉族前列腺癌病理分级高分化者12例(23.1％)、48例(21.4％),中分化者17例(32.7％)、72例(32.1％),低分化者23例(44.2％)、104例(46.4％),组间比较差异无统计学意义(Z=-0.316,P=0.752).④线性相关性分析显示,前列腺癌检出率与维吾尔族、汉族的年龄存在相关性(r=10.130、P=0.017,r=37.666、P=0.000),与维吾尔族、汉族的PSA亦存在相关性(r=32.577、P=0.000,r=81.291、P=0.000). 结论 新疆地区维吾尔族前列腺穿刺患者在不同年龄的tPSA值、不同tPSA水平的前列腺癌检出率均低于同水平的汉族人群,但差异无统计学意义.维吾尔族和汉族的前列腺癌病理分级构成比相似.前列腺癌检出率与汉族、维吾尔族的年龄与PSA水平均存在相关性.
目的 探討新疆地區維吾爾族與漢族前列腺癌髮病差異以及可能的影響因素.方法 迴顧性分析2007年5月至2013年10月以下尿路癥狀就診且年齡＞50歲的維吾爾族和漢族患者,患者行PSA檢測、直腸指檢及經腹前列腺超聲、MRI檢查.符閤前列腺穿刺活檢指徵者696例,其中維吾爾族152例、漢族544例,對兩組患者不同年齡tPSA、不同tPSA水平前列腺癌檢齣率以及病理分級進行對比分析.tPSA值以中位數(四分位間距)錶示. 結果 ①696例維吾爾族、漢族前列腺穿刺患者的tPSA值為15.5 (25.9)、18.7(36.7) μg/L,按照年齡分層,50 ～ 59歲組分彆為11.1(1 1.6)、11.8(17.9) μg/L,60～ 69歲組15.6(39.0)、16.5 (33.0)μg/L,70 ～ 79歲組17.4(25.1)、18.3(40.2)μg/L,≥80歲組11.7(19.4)、44.4(71.5) μg/L.前列腺穿刺患者維吾爾族各年齡組tPSA水平均低于漢族,但僅≥80歲組差異有統計學意義,其餘3組差異均無統計學意義(P＞0.05).②共檢齣276例前列腺癌患者.維吾爾族、漢族前列腺癌檢齣率分彆為34.2％ (52/152)、41.2％ (224/544),按照PSA分層,＜4 μg/L組分彆為0(0)、29.2％(7/24),4～ 10 μg/L組16.1％ (5/31)、17.0％(18/106),＞10～ 20 μg/L組14.3％ (7/49)、19.9％ (31/156),＞20μg/L組64.5％(40/62)、65.1％(168/258).維吾爾族各tPSA水平組前列腺癌檢齣率均低于漢族,但差異多無統計學意義(P＞0.05).③維吾爾族、漢族前列腺癌病理分級高分化者12例(23.1％)、48例(21.4％),中分化者17例(32.7％)、72例(32.1％),低分化者23例(44.2％)、104例(46.4％),組間比較差異無統計學意義(Z=-0.316,P=0.752).④線性相關性分析顯示,前列腺癌檢齣率與維吾爾族、漢族的年齡存在相關性(r=10.130、P=0.017,r=37.666、P=0.000),與維吾爾族、漢族的PSA亦存在相關性(r=32.577、P=0.000,r=81.291、P=0.000). 結論 新疆地區維吾爾族前列腺穿刺患者在不同年齡的tPSA值、不同tPSA水平的前列腺癌檢齣率均低于同水平的漢族人群,但差異無統計學意義.維吾爾族和漢族的前列腺癌病理分級構成比相似.前列腺癌檢齣率與漢族、維吾爾族的年齡與PSA水平均存在相關性.
목적 탐토신강지구유오이족여한족전렬선암발병차이이급가능적영향인소.방법 회고성분석2007년5월지2013년10월이하뇨로증상취진차년령＞50세적유오이족화한족환자,환자행PSA검측、직장지검급경복전렬선초성、MRI검사.부합전렬선천자활검지정자696례,기중유오이족152례、한족544례,대량조환자불동년령tPSA、불동tPSA수평전렬선암검출솔이급병리분급진행대비분석.tPSA치이중위수(사분위간거)표시. 결과 ①696례유오이족、한족전렬선천자환자적tPSA치위15.5 (25.9)、18.7(36.7) μg/L,안조년령분층,50 ～ 59세조분별위11.1(1 1.6)、11.8(17.9) μg/L,60～ 69세조15.6(39.0)、16.5 (33.0)μg/L,70 ～ 79세조17.4(25.1)、18.3(40.2)μg/L,≥80세조11.7(19.4)、44.4(71.5) μg/L.전렬선천자환자유오이족각년령조tPSA수평균저우한족,단부≥80세조차이유통계학의의,기여3조차이균무통계학의의(P＞0.05).②공검출276례전렬선암환자.유오이족、한족전렬선암검출솔분별위34.2％ (52/152)、41.2％ (224/544),안조PSA분층,＜4 μg/L조분별위0(0)、29.2％(7/24),4～ 10 μg/L조16.1％ (5/31)、17.0％(18/106),＞10～ 20 μg/L조14.3％ (7/49)、19.9％ (31/156),＞20μg/L조64.5％(40/62)、65.1％(168/258).유오이족각tPSA수평조전렬선암검출솔균저우한족,단차이다무통계학의의(P＞0.05).③유오이족、한족전렬선암병리분급고분화자12례(23.1％)、48례(21.4％),중분화자17례(32.7％)、72례(32.1％),저분화자23례(44.2％)、104례(46.4％),조간비교차이무통계학의의(Z=-0.316,P=0.752).④선성상관성분석현시,전렬선암검출솔여유오이족、한족적년령존재상관성(r=10.130、P=0.017,r=37.666、P=0.000),여유오이족、한족적PSA역존재상관성(r=32.577、P=0.000,r=81.291、P=0.000). 결론 신강지구유오이족전렬선천자환자재불동년령적tPSA치、불동tPSA수평적전렬선암검출솔균저우동수평적한족인군,단차이무통계학의의.유오이족화한족적전렬선암병리분급구성비상사.전렬선암검출솔여한족、유오이족적년령여PSA수평균존재상관성.
Objective To investigate the differences in prostate cancer between Uygur and Han ethnic groups in Xinjiang and the possible factors influencing the differences.Methods A retrospective analysis was done in Uygur and Han patients over 50 years with lower urinary tract symptoms (LUTS) from May 2007 to October 2013.Six hundred and ninety-six patients (Uygur:152,Han:544) complying with prostate biopsy were picked out after PSA test,digital rectal examination,prostate ultrasound transabdominal and MRI.They were divided into 4 age groups based on every l0 years:50-59 years group,60-69 years group,70-79 years group,and ≥ 80 years group.A comparison was made in different tPSA levels of prostate cancer detection rates and pathological grading of Uygur and Han groups.Results The tPSA levels of Uygurs were as follows:50-59 years group:11.1 (11.6) μg/L; 60-69 years group:15.6 (39.0) μg/L; 70-79 years group:17.4 (25.1) μg/L; ≥ 80 years group:11.7 (19.4) μg/L.While the tPSA levels of Hans were as follows:50-59 years group:11.8 (17.9) μg/L; 60-69 years group:16.5 (33.0) μg/L; 70-79 years group:18.3 (40.2) μg/L; ≥80 years group:44.4 (71.5) μg/L.The tPSA level of Uygur cases in any age group was lower than that of Hans.Among 276 patients diagnosed with prostate cancer,the detection rates of Uygurs were as follows:＜4 μg/L group:0 (0) ; 4-10 μg/L group:16.1％ (5/31) ; ＞10-20 μg/L group:14.3％ (7/49); ＞20 μg/L group:64.5％ (40/62) and the detection rates of Hans were as follows:＜4 μg/L group:29.2％ (7/24); 4-10 μg/L group:17.0％(18/106); ＞10-20 μg/L group:19.9％ (31/ 156) ; ＞20 μg/L group:65.1％ (168/258).The detection rate of Uygurs in each group was lower than that of Hans but there were no significant differences (P＞0.05).Pathological grading of prostate cancer between Uygur and Han cases were listed as follows:the well differentiated group:Uygur:12 (23.1％),Han:48 (21.4％) ; the moderately differentiated group:Uygur:17 (32.7％),Han:72 (32.1％) ; the poorly differentiated group:Uygur:23 (44.2％),Han:104 (46.4％).The levels between Uygurs and Hans were nearly the same (Z=-0.316),showing no significant difference (P =0.752).The prostate cancer detection rate was correlated with the ages of Uygurs and Hans (r=10.130,P=0.017; r=37.666,P=0.000),and the prostate cancer detection rate was also correlated with the PSA levels of Uygurs and Hans (r=32.577,P =0.000; r=81.291,P=0.000).Conclusions The tPSA level of Uygur cases in any age group and the detection rate of prostate cancer of Uygurs in each PSA group are lower than those of Hans but there are almost no significant differences.The prostate cancer detection rate is correlated with the ages and PSA levels of Uygurs and Hans.
