CAJ | 학술논문

目的评价腹腔喷射通气对家猪腹膜氧合的影响.方法健康家猪24只,雌雄不拘,12～ 16周龄,体重35 ～ 45 kg,采用随机数字表法,将其随机分为3组(n=8):假手术组(S组)、腹腔常频通气组(N组)及腹腔高频通气组(H组).麻醉诱导后经口行气管插管,机械通气,于气道机械通气35 min时进行腹腔喷射通气,驱动压0.5 kg/cm2,纯氧流量1.8 L/min,吸呼比1.0:1.5,N组和H组通气频率分别为16和150次/min,腹腔通气期间每隔30 s采集动脉血样,进行血气分析,当脉搏血氧饱和度≤90％时停止腹腔通气.记录无通气安全时间(腹腔通气开始至PaO2＜ 60 mm Hg的时间).结果与S组和N组比较,H组PaO2升高,无通气安全时间延长(P＜ 0.05),3组间PaCO2差异无统计学意义(P＞ 0.05).结论腹腔高频喷射通气可提高家猪腹膜氧合的效果,且可延长无通气安全时间,而腹腔常频喷射通气对家猪腹膜氧合无影响.
목적 평개복강분사통기대가저복막양합적영향.방법 건강가저24지,자웅불구,12～ 16주령,체중35 ～ 45 kg,채용수궤수자표법,장기수궤분위3조(n=8):가수술조(S조)、복강상빈통기조(N조)급복강고빈통기조(H조).마취유도후경구행기관삽관,궤계통기,우기도궤계통기35 min시진행복강분사통기,구동압0.5 kg/cm2,순양류량1.8 L/min,흡호비1.0:1.5,N조화H조통기빈솔분별위16화150차/min,복강통기기간매격30 s채집동맥혈양,진행혈기분석,당맥박혈양포화도≤90％시정지복강통기.기록무통기안전시간(복강통기개시지PaO2＜ 60 mm Hg적시간).결과 여S조화N조비교,H조PaO2승고,무통기안전시간연장(P＜ 0.05),3조간PaCO2차이무통계학의의(P＞ 0.05).결론 복강고빈분사통기가제고가저복막양합적효과,차가연장무통기안전시간,이복강상빈분사통기대가저복막양합무영향.
Objective To evaluate the effects of peritoneal jet ventilation on peritoneal oxygenation in pigs.Methods Twenty-four pigs of both sexes (12-16 weeks,35-45 kg) were randomly divided into 3 groups (n=8 each): sham operation group (group S) ; peritoneal regular frequency jet ventilation group (16 bpm)(group N) and peritoneal high-frequency jet ventilation group (150 bpm) (group H).Oral tracheal intubation was performed.The animals were mechanically ventilated (VT 8-12 ml/kg,RR 12-16 bpm,I:E 1.0:1.5,FiO2 100％) via airway.Endotracheal tubes were inserted into abdomen through the incisions in the left lower (for peritoneal jet ventilation) and right upper quadrant (for outlet of air).Arterial blood PaO2 and PaCO2 were measured before (baseline) and at 30,60,90,120,150,180,210 and 240 s of peritoneal jet ventilation.Peritoneal jet ventilation was started after the lungs being mechanically ventilated for 35 min.Peritoneal jet ventilation was terminated when SpO2 dropped to SpO2 ＜ 90 ％.The duration of safe apnea (DSA,from the moment of begging of peritoneal jet ventilation to the time when PaO2 ＜ 60 mm Hg).Results PaO2 was significandy higher and DSA longer in group H than in groups S and N.But there was no significant difference in PaCO2 among the 3 groups.Conclusion Peritoneal high-frequency jet ventilation can significantly enhance the efficiency of peritoneal oxygenation and prolong DSA,while peritoneal regular frequency jet ventilation has no effect on peritoneal oxygenation.