CAJ | 학술논문

目的评价体外循环回路对预充液舒芬太尼浓度的影响.方法实验分为2组(n=6):西京90型大号鼓泡式氧合器体外循环回路组(A组)和玻璃容器组(B组).将预充液(琥珀酰明胶液1000ml和乳酸钠林格氏液1000 ml)预充入大号鼓泡式氧合器体外循环装置或玻璃容器中,从静脉贮血器的静脉端或玻璃容器口快速加入舒芬太尼15μg(浓度为7.5 ng/ml).在加药后3、5、10、20、30、40、50、60、70、80、90 min时,从静脉贮血器的动脉端或玻璃容器中抽取预充液1 ml,采用气相色谱质谱法检测舒芬太尼浓度.结果与B组比较,A组各时点预充液舒芬太尼浓度明显降低(P＜0.05).结论体外循环回路对预充液舒芬太尼有明显吸附作用.
목적 평개체외순배회로대예충액서분태니농도적영향.방법 실험분위2조(n=6):서경90형대호고포식양합기체외순배회로조(A조)화파리용기조(B조).장예충액(호박선명효액1000ml화유산납림격씨액1000 ml)예충입대호고포식양합기체외순배장치혹파리용기중,종정맥저혈기적정맥단혹파리용기구쾌속가입서분태니15μg(농도위7.5 ng/ml).재가약후3、5、10、20、30、40、50、60、70、80、90 min시,종정맥저혈기적동맥단혹파리용기중추취예충액1 ml,채용기상색보질보법검측서분태니농도.결과 여B조비교,A조각시점예충액서분태니농도명현강저(P＜0.05).결론 체외순배회로대예충액서분태니유명현흡부작용.
Objective To investigate the effect of extracorporeal cjrcuit on the concentration of sufentanil the priming solution.Methods The extracorporeal circuit (ECC) of Xi-jing-90 type (group A) was used in the study,while incontrol group (group B) a glass container was used.The ECC and glass container were filled with priming solution (succinylated Gelatin 1000 ml + lactated Ringer's solution 1000 ml).Sufentanil 15 μg was then added to the priming solution (the final concentration was 7.5 ng/ml).The priming solution was circulated in the closed ECC or stirred in the glass container.The concentration of sufentanil in the priming solution was determined at 3,5,10,20,30,40,50,60,70,80 and 90 min after addition of sufentanil by gas chromatography.Results The sufentanil concentration in.the priming solution decreased in group A at the different time points respectively as compared with group B (P ＜ 0.05).Conclusion Sufentanil can significantly be absorbed by the extracorporeal circuit.