CAJ | 학술논문

目的确定复合右美托咪定时丙泊酚抑制病人置入喉罩反应的半数有效血浆靶浓度(EC50).方法择期全麻病人,性别不限,年龄20 ～ 60岁,体重指数20～ 25 kg/m2,ASA分级Ⅰ或Ⅱ级,采用改良Dixon序贯法进行试验.静脉输注右美托咪定1.0 μg/kg,输注时间10 min,随后靶控输注丙泊酚,初设血浆靶浓度3.0 μg/ml,当丙泊酚效应室浓度与血浆浓度达平衡,BIS值达50～ 60时置入喉罩.根据是否发生喉罩置入反应确定下1例病人的异丙酚靶浓度,浓度梯度0.2 μg/ml.发生置入喉罩反应的标准为出现咳嗽、体动、喉痉挛或全身有意识的体动.计算复合右美托咪定时丙泊酚抑制病人置入喉罩反应的EC50及其95％可信区间(95％CI).结果复合右美托咪定1.0 μg/kg时丙泊酚抑制病人置入喉罩反应的EC50及其95％CI为2.351(1.737～ 2.600) μg/ml.结论复合右美托咪定1.0μg/kg时丙泊酚抑制病人置入喉罩反应的EC50为2.351 μg/ml.
목적 학정복합우미탁미정시병박분억제병인치입후조반응적반수유효혈장파농도(EC50).방법 택기전마병인,성별불한,년령20 ～ 60세,체중지수20～ 25 kg/m2,ASA분급Ⅰ혹Ⅱ급,채용개량Dixon서관법진행시험.정맥수주우미탁미정1.0 μg/kg,수주시간10 min,수후파공수주병박분,초설혈장파농도3.0 μg/ml,당병박분효응실농도여혈장농도체평형,BIS치체50～ 60시치입후조.근거시부발생후조치입반응학정하1례병인적이병분파농도,농도제도0.2 μg/ml.발생치입후조반응적표준위출현해수、체동、후경련혹전신유의식적체동.계산복합우미탁미정시병박분억제병인치입후조반응적EC50급기95％가신구간(95％CI).결과 복합우미탁미정1.0 μg/kg시병박분억제병인치입후조반응적EC50급기95％CI위2.351(1.737～ 2.600) μg/ml.결론 복합우미탁미정1.0μg/kg시병박분억제병인치입후조반응적EC50위2.351 μg/ml.
Objective To determine the median effective target plasma concentration (EC50) of propofol inhibiting the response to laryngeal mask airway (LMA) insertion when combined with dexmedetomidine.Methods ASA Ⅰ or Ⅱ patients of both sexes,aged 20-60 yr,with body mass index 20-25 kg/m2,scheduled for surgeries under general anesthesia,were studied.EC50 of propofol was determined by modified Dixon' s up-and-down sequential experiment.After dexmedetomidine 1.0 μg/kg was infused over 10 min,propofol was infused by targetcontrolled infusion.The initial target plasma concentration of propofol was set at 3.0 μg/ml.LMA was inserted when the target effect-site concentration of propofol and target plasma concentration of propofol reached the balance and BIS value was 50-60.Each time the target concentration increased/decreased by 0.2 μg/ml according to the occurrence of the response to LMA insertion.The response to LMA insertion was defined as the occurrence of coughing,body movement,laryngospasm or systemic voluntary movement.EC50 and 95 ％ confidence interval (CI)of propofol for inhibition of the response to LMA insertion were calculated.Results The EC50 of propofol required for inhibition of the response to LMA insertion was 2.351 (95％ Cl 1.737-2.600) μg/ml when combined with dexmedetomidine 1.0 μg/kg.Conclusion The EC50 of propofol inhibiting the response to LMA insertion is 2.351 μg/ml when combined with dexmedetomidine.