CAJ | 학술논문

目的采用meta分析方法评价帕瑞昔布钠用于超前镇痛的有效性.方法检索PubMed、Embase、Cochrane数据库和CNKI数据库,不限定发表时间和语言.收集帕瑞昔布钠应用于超前镇痛的随机安慰剂对照研究.采用改良Jadad法评价文献质量.以术后1、6、12和24h时视觉模拟评分(VAS评分)、术后24 h内吗啡用量、术后恶心呕吐发生情况为评价指标.采用RevMan 5.0.2软件进行meta分析.结果纳入14项研究,Jadad评分均≥4分,包括1086例患者.分为安慰剂组和术前静脉注射帕瑞昔布钠40 mg组.Meta分析结果显示:与安慰剂组比较,术前静脉注射帕瑞昔布钠40mg组术后1、6、12和24 h时VAS评分降低,术后24 h内吗啡用量减少,术后恶心呕吐发生率降低(P＜0.05).结论术前静脉注射帕瑞昔布钠40 mg可产生显著的超前镇痛效果,有助于降低术后镇痛的不良反应.
목적 채용meta분석방법평개파서석포납용우초전진통적유효성.방법 검색PubMed、Embase、Cochrane수거고화CNKI수거고,불한정발표시간화어언.수집파서석포납응용우초전진통적수궤안위제대조연구.채용개량Jadad법평개문헌질량.이술후1、6、12화24h시시각모의평분(VAS평분)、술후24 h내마배용량、술후악심구토발생정황위평개지표.채용RevMan 5.0.2연건진행meta분석.결과 납입14항연구,Jadad평분균≥4분,포괄1086례환자.분위안위제조화술전정맥주사파서석포납40 mg조.Meta분석결과현시:여안위제조비교,술전정맥주사파서석포납40mg조술후1、6、12화24 h시VAS평분강저,술후24 h내마배용량감소,술후악심구토발생솔강저(P＜0.05).결론 술전정맥주사파서석포납40 mg가산생현저적초전진통효과,유조우강저술후진통적불량반응.
Objective To evaluate the efficacy of parecoxib sodium for preemptive analgesia.Methods PubMed,EMBASE,Cochrane Library,and CNKI database were searched for randomized placebo-controlled trials involving the efficacy of parecoxib sodium for preemptive analgesia.The modified Jadad scale was used for quality assessment.Evaluation indexes included VAS scores at 1,6,12 and 24 h after operation,consumption of morphine within 24 h after operation,and incidences of nausea and vomiting after operation.Meta-analysis was conducted using the Cochrane Collaboration's RevMan 5.0.2 software.Results Fourteen randomized placebo-controlled trials involving 1086 patients were included in our meta-analysis.The modified Jadad scale scores for the 14 studies were ≥ 4.The patients were divided into 2 groups:placebo group and parecoxib sodium 40 mg injected before operation group.The results of meta-analysis showed that VAS scores at 1,6,12 and 24 h after operation were significantly decreased,the consumption of morphine within 24 h after operation was reduced,and the incidences of nausea and vomiting after operation were decreased in parecoxib sodium 40 mg injected before operation group as compared with placebo group (P ＜ 0.05).Conclusion Intravenous injection of parecoxib sodium 40 mg before operation can produce significant preemptive analgesic efficacy and is helpful in decreasing the adverse effect of postoperative analgesia.