CAJ | 학술논문

为观察在二甲双胍治疗糖尿病时对维生素B12的影响,探讨甲基丙二酸对诊断维生素B12缺乏的价值,本研究选取126例2型糖尿病患者进行研究,发现应用二甲双胍可导致糖尿病患者血清维生素B12水平降低[(501.62±219.98对762.86±360.92)ng/L,P＜0.01]；尿甲基丙二酸对维生素B12早期缺乏的诊断价值较高,其敏感性、特异性为81.25％、83.75％.
위관찰재이갑쌍고치료당뇨병시대유생소B12적영향,탐토갑기병이산대진단유생소B12결핍적개치,본연구선취126례2형당뇨병환자진행연구,발현응용이갑쌍고가도치당뇨병환자혈청유생소B12수평강저[(501.62±219.98대762.86±360.92)ng/L,P＜0.01]；뇨갑기병이산대유생소B12조기결핍적진단개치교고,기민감성、특이성위81.25％、83.75％.
The aim of the study was to investigate the influence of metformin on serum vitamin B12 in patients with type 2 diabetes mellitus,and to determine the value of methylmalonic acid in the diagnosis of vitamin B12 deficiency.126 type 2 diabetic patients were recruited.The results showed that metformin lowered serum vitamin B12 level in these patients [(501.62 ± 219.98 vs 762.86 ± 360.92) ng/L,P＜0.01].Urinary methylmalonic acid may be a candidate biochemical indicator for early diagnosis of vitamin B12 deficiency in the diabetic patients,with high sensitivity (81.25％) and specificity (83.75％).