CAJ | 학술논문

906例因高度疑诊冠心病行选择性冠状动脉造影并且既往无糖尿病病史的患者纳入本研究.根据空腹血糖(FPG)水平,将研究人群分为≤5.5 mmol/L、5.6～6.0 mmol/L、6.1～ 6.9 mmoL/L和≥7.0 mmol/L组.主要冠状动脉或其主要分支直径有≥50％的狭窄即诊断为冠心病,冠状动脉病变严重程度以Gensini评分表示.对各组人群进行一般临床资料、生化指标、冠状动脉造影资料的比较,并分析与冠心病发生以及冠状动脉病变严重程度相关的危险因素.结果显示,4组间随着FPG水平升高冠心病发生比例逐渐增高,冠状动脉病变支数逐渐增多,Gensini评分逐渐增加,差异有统计学意义(P＜0.05或P＜0.01).FPG与冠心病发生(P=0.004)和Gensini评分明显相关(P=0.010),提示FPG是冠心病发生以及冠状动脉病变加重的独立危险因素.
906례인고도의진관심병행선택성관상동맥조영병차기왕무당뇨병병사적환자납입본연구.근거공복혈당(FPG)수평,장연구인군분위≤5.5 mmol/L、5.6～6.0 mmol/L、6.1～ 6.9 mmoL/L화≥7.0 mmol/L조.주요관상동맥혹기주요분지직경유≥50％적협착즉진단위관심병,관상동맥병변엄중정도이Gensini평분표시.대각조인군진행일반림상자료、생화지표、관상동맥조영자료적비교,병분석여관심병발생이급관상동맥병변엄중정도상관적위험인소.결과현시,4조간수착FPG수평승고관심병발생비례축점증고,관상동맥병변지수축점증다,Gensini평분축점증가,차이유통계학의의(P＜0.05혹P＜0.01).FPG여관심병발생(P=0.004)화Gensini평분명현상관(P=0.010),제시FPG시관심병발생이급관상동맥병변가중적독립위험인소.
A total of 906 subjects with no history of diabetes who had undergone coronary angiography were included in this study and categorized into four groups according to the level of fasting plasma glucose (FPG):≤5.5 mmoL/L,5.6-6.0 mmol/L,6.1-6.9 mmoL/L,and ≥ 7.0 mmol/L.Significant coronary artery disease (CAD) was defined as ≥ 50％ reduction of lumen diameter at least in one major coronary artery.The severity of coronary atherosclerosis was defined by the Gensini score.The clinical data,laboratory indexes,and coronary angiography results were compared among various groups.The risk factors for the prevalence and severity of angiographic CAD were analyzed.The results showed that the prevalence of angiographic CAD,the number of diseased vessels,and the Gensini score were increasing with increasing FPG levels among four groups (P＜0.05 or P＜0.01).The FPG level was significantly correlated with angiographic CAD (P =0.004) and the Gensini score (P =0.010),suggesting that FPG was an independent risk factor for the prevalence and severity of angiographic CAD.