CAJ | 학술논문

采用酶联免疫吸附法检测2型糖尿病合并非酒精性脂肪肝(NAFLD)患者血中成纤维细胞生长因子21(FGF-21)水平,结果显示,2型糖尿病合并NAFLD患者的血清FGF-21水平高于单纯2型糖尿病患者[(266.55 ±21.24对220.32±22.68)ng/L,P＜0.01],且2组均高于正常对照组[(173.52±16.18)ng/L,P＜0.01].血清FGF-21水平与腰围、血糖、甘油三酯等呈正相关.FGF-21可能在2型糖尿病患者合并非酒精性脂肪肝的发生发展中发挥作用.
채용매련면역흡부법검측2형당뇨병합병비주정성지방간(NAFLD)환자혈중성섬유세포생장인자21(FGF-21)수평,결과현시,2형당뇨병합병NAFLD환자적혈청FGF-21수평고우단순2형당뇨병환자[(266.55 ±21.24대220.32±22.68)ng/L,P＜0.01],차2조균고우정상대조조[(173.52±16.18)ng/L,P＜0.01].혈청FGF-21수평여요위、혈당、감유삼지등정정상관.FGF-21가능재2형당뇨병환자합병비주정성지방간적발생발전중발휘작용.
The level of serum fibroblast growth factor-21 (FGF-21) in patients with type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease (NAFLD) was determined by ELISA.The results showed that serum FGF-21 level in these patients was higher than that in type 2 diabetic patients [(266.55 ± 21.24 vs 220.32 ± 22.68) ng/L,P＜ 0.01].Serum FGF-21 levels in both groups were significantly higher than that in normal control group [(173.52 ± 16.18) ng/L,P＜0.01].Serum FGF-21 level was positively correlated with waist circumference,blood glucose,and triglyceride.FGF-21 may contribute to the development of NAFLD in the patients with type 2 diabetes mellitus.