CAJ | 학술논문

目的探讨前蛋白转化酶枯草溶菌素9(PCSK9)在绝经前和绝经后女性中的差异及其与代谢因素的相关性.方法从2009年参加南京2型糖尿病预测、预防、干预研究调查人群中随机抽取515名女性,收集空腹血样本,并对入选者进行问卷调查、体格检查及代谢相关指标的测定,用酶联免疫吸附法检测血清PCSK9水平.结果在女性人群中血清PCSK9水平与低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、甘油三酯、空腹血糖、体重指数、腰臀比、年龄呈正相关(均P＜0.01),绝经前女性的PCSK9水平显著低于绝经后的女性[(58.18±25.44对80.91±33.74)ng/ml,P＜0.01].结论绝经前女性的PCSK9水平低于绝经后女性,且PCSK9水平与年龄、TC、LDL-C密切相关.
목적 탐토전단백전화매고초용균소9(PCSK9)재절경전화절경후녀성중적차이급기여대사인소적상관성.방법 종2009년삼가남경2형당뇨병예측、예방、간예연구조사인군중수궤추취515명녀성,수집공복혈양본,병대입선자진행문권조사、체격검사급대사상관지표적측정,용매련면역흡부법검측혈청PCSK9수평.결과 재녀성인군중혈청PCSK9수평여저밀도지단백담고순(LDL-C)、총담고순(TC)、감유삼지、공복혈당、체중지수、요둔비、년령정정상관(균P＜0.01),절경전녀성적PCSK9수평현저저우절경후적녀성[(58.18±25.44대80.91±33.74)ng/ml,P＜0.01].결론 절경전녀성적PCSK9수평저우절경후녀성,차PCSK9수평여년령、TC、LDL-C밀절상관.
Objective To compare proprotein convertase subtilisin/kexin type 9 (PCSK9) levels between premenopausal and postmenopausal women,and to investigate the relationship between serum PCSK9 and metabolic factors.Methods Totally 515 women were enrolled from the study on diabetes of prediction,prevention,and intervention in Nanjing in 2009.Survey,physical examinations,and determination of related metabolic indexes were performed.Serum PCSK9 level was measured by sandwich ELISA.Results Serum PCSK9 level was positively correlated with low density lipoprotein-cholesterol (LDL-C),total cholesterol (TC),triglyceride,fasting plasma glucose,body mass index,waist-hip ratio,and age in women (all P＜0.01).PCSK9 level was significantly lower in premenopausal women than that in postmenopausal women [(58.18 ± 25.44 vs 80.91 ± 33.74) ng/ml,P ＜0.01].Conclusion Higher level of PCSK9 exists in postmenopausal women compared with premenopausal women.The level of PCSK9 is closely correlated with age,TC,and LDL-C.