CAJ | 학술논문

Graves病(GD),也称弥漫性甲状腺肿伴甲状腺功能亢进症,是一种由环境和遗传因素共同致病的多基因疾病.在目前公认的9个GD易感基因中,SCGB3A2是唯一一个利用标签单核苷酸多态性(tagSNP)技术、通过定位克隆策略识别鉴定的一个易感基因,并随后在英国和俄罗斯两个独立样本的研究中得到证实.目前多基因疾病研究专家一致认为SCGB3A2是GD的一个新的致病易感基因.
Graves병(GD),야칭미만성갑상선종반갑상선공능항진증,시일충유배경화유전인소공동치병적다기인질병.재목전공인적9개GD역감기인중,SCGB3A2시유일일개이용표첨단핵감산다태성(tagSNP)기술、통과정위극륭책략식별감정적일개역감기인,병수후재영국화아라사량개독립양본적연구중득도증실.목전다기인질병연구전가일치인위SCGB3A2시GD적일개신적치병역감기인.
Graves' disease is a common autoimmune disease triggered by the susceptibility genes and environmental factors.Among the 9 risk genes related to Graves' disease,SCGB3A2 is the first Graves' disease-predisposing gene identified by our group using tagSNPs,strategy of candidate genes,and positional clones.The association between SCGB3A2 and Graves' disease has been confirmed by two independent cohorts from UK and Russia.So far,the geneticists on Graves' disease regard SCGB3A2 as a validated susceptibility gene of that disease.