CAJ | 학술논문

2010年2月至2011年10月在宁波大学医学院附属医院和宁波江北妇保所妇产科门诊就诊的妊娠早期妇女(孕周为4周～12周)1 360名,同时以同期来院体检的216名健康非妊娠妇女作为对照组.采集所有研究对象的血、尿样本,应用酸消化砷-铈法测定尿碘,化学发光法测定血清游离甲状腺素(FT4),游离三碘甲状腺原氨酸(FT3),总甲状腺素(TT4),总三碘甲状腺原氨酸(TT3),促甲状腺素(TSH),甲状腺过氧化物酶抗体(TPOAb).妊娠早期妇女与非妊娠妇女尿碘水平差异无统计学意义(P＞0.05)；1 360名妊娠早期妇女中,发现有各种甲状腺功能异常或甲状腺抗体阳性268例(19.71％).216名对照非妊娠妇女中有各种甲状腺功能异常或甲状腺抗体阳性29例(13.43％),两组各种甲状腺功能异常或甲状腺抗体阳性患病率差异有统计学意义(x2=4.40,P＜0.05).19.71％的妊娠早期妇女存在甲状腺功能异常或TPOAb阳性.孕妇在孕早期即出现甲状腺功能异常患病率增加,建议开展妊娠早期甲状腺功能和自身抗体常规筛查.
2010년2월지2011년10월재저파대학의학원부속의원화저파강북부보소부산과문진취진적임신조기부녀(잉주위4주～12주)1 360명,동시이동기래원체검적216명건강비임신부녀작위대조조.채집소유연구대상적혈、뇨양본,응용산소화신-시법측정뇨전,화학발광법측정혈청유리갑상선소(FT4),유리삼전갑상선원안산(FT3),총갑상선소(TT4),총삼전갑상선원안산(TT3),촉갑상선소(TSH),갑상선과양화물매항체(TPOAb).임신조기부녀여비임신부녀뇨전수평차이무통계학의의(P＞0.05)；1 360명임신조기부녀중,발현유각충갑상선공능이상혹갑상선항체양성268례(19.71％).216명대조비임신부녀중유각충갑상선공능이상혹갑상선항체양성29례(13.43％),량조각충갑상선공능이상혹갑상선항체양성환병솔차이유통계학의의(x2=4.40,P＜0.05).19.71％적임신조기부녀존재갑상선공능이상혹TPOAb양성.잉부재잉조기즉출현갑상선공능이상환병솔증가,건의개전임신조기갑상선공능화자신항체상규사사.
Totally 1 360 pregnant women during the first trimesters (4-12 weeks) who visited Ningbo University Affiliated Hospital and Ningbo Jiangbei Maternal Health Hospital from February 2010 to October 2011,and 216 non-pregnant healthy women,who contemporaneous by visited the hospital,were enrolled in this study.The thyroid screening was made by determining urinary iodine and serum free thyroxine,free triiodothyronine,total thyroxine,total triiodothyronine,thyrotropin,and thyroid peroxidase antibody (TPOAb).The median concentration of urinary iodine in the pregnant women was not different from that of non-pregnant women (P＞0.05) ; 1 360 pregnant women were screened,268 (19.71％) of them were identified to suffer from thyroid disorders or with positive thyroid autoantibody.29(13.43％) of non-pregnant women were identified to suffer from thyroid disorders or with positive thyroid autoantibody.There was significant difference between the 2 groups (x2 =4.40,P＜0.05).Prevalence of thyroid dysfunction may increase during early pregnancy.The screening for thyroid function and autoantibody should be recommended in that period.