中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2013年
3期
232-235
,共4页
陈瑞敏%张莹%杨晓红%林祥泉
陳瑞敏%張瑩%楊曉紅%林祥泉
진서민%장형%양효홍%림상천
特纳综合征%桥本甲状腺炎%核型
特納綜閤徵%橋本甲狀腺炎%覈型
특납종합정%교본갑상선염%핵형
Turner syndrome%Hashimoto's thyroiditis%Karyotype
目的 观察Turner综合征(TS)患儿甲状腺异常的发生率、甲状腺自身抗体阳性与甲状腺功能异常及与年龄、核型之间的关系.方法 对55例经染色体分析确诊的TS患儿,采用化学发光法检测血清甲状腺功能及甲状腺自身抗体(TAA),将患儿分为TAA阳性组与TAA阴性组.结果 检出TAA阳性21例(38.2％),TAA阳性患者中甲状腺功能异常10例,其中7例为甲状腺功能低下,3例为甲状腺功能亢进.34例TAA阴性患儿检测甲状腺功能均正常.TAA阳性组与TAA阴性组年龄分别为(12.16±2.55)岁及(9.95±4.50)岁(P＜0.05),其中6例0～5岁患儿无l例出现TAA阳性,5～10岁TAA阳性比例为31.3％ (5/16),而10 ～15岁及15岁以上2组TAA的阳性比例分别为48.1％ (13/27)和50.0％ (3/6).TS各种核型之间TAA阳性例数差异无统计学意义(P＞0.05).结论 5岁后TS患儿容易并发桥本甲状腺炎导致甲状腺功能异常,应定期检测TAA及甲状腺功能.TS患儿发生桥本甲状腺炎与其染色体核型类型无关.
目的 觀察Turner綜閤徵(TS)患兒甲狀腺異常的髮生率、甲狀腺自身抗體暘性與甲狀腺功能異常及與年齡、覈型之間的關繫.方法 對55例經染色體分析確診的TS患兒,採用化學髮光法檢測血清甲狀腺功能及甲狀腺自身抗體(TAA),將患兒分為TAA暘性組與TAA陰性組.結果 檢齣TAA暘性21例(38.2％),TAA暘性患者中甲狀腺功能異常10例,其中7例為甲狀腺功能低下,3例為甲狀腺功能亢進.34例TAA陰性患兒檢測甲狀腺功能均正常.TAA暘性組與TAA陰性組年齡分彆為(12.16±2.55)歲及(9.95±4.50)歲(P＜0.05),其中6例0～5歲患兒無l例齣現TAA暘性,5～10歲TAA暘性比例為31.3％ (5/16),而10 ～15歲及15歲以上2組TAA的暘性比例分彆為48.1％ (13/27)和50.0％ (3/6).TS各種覈型之間TAA暘性例數差異無統計學意義(P＞0.05).結論 5歲後TS患兒容易併髮橋本甲狀腺炎導緻甲狀腺功能異常,應定期檢測TAA及甲狀腺功能.TS患兒髮生橋本甲狀腺炎與其染色體覈型類型無關.
목적 관찰Turner종합정(TS)환인갑상선이상적발생솔、갑상선자신항체양성여갑상선공능이상급여년령、핵형지간적관계.방법 대55례경염색체분석학진적TS환인,채용화학발광법검측혈청갑상선공능급갑상선자신항체(TAA),장환인분위TAA양성조여TAA음성조.결과 검출TAA양성21례(38.2％),TAA양성환자중갑상선공능이상10례,기중7례위갑상선공능저하,3례위갑상선공능항진.34례TAA음성환인검측갑상선공능균정상.TAA양성조여TAA음성조년령분별위(12.16±2.55)세급(9.95±4.50)세(P＜0.05),기중6례0～5세환인무l례출현TAA양성,5～10세TAA양성비례위31.3％ (5/16),이10 ～15세급15세이상2조TAA적양성비례분별위48.1％ (13/27)화50.0％ (3/6).TS각충핵형지간TAA양성례수차이무통계학의의(P＞0.05).결론 5세후TS환인용역병발교본갑상선염도치갑상선공능이상,응정기검측TAA급갑상선공능.TS환인발생교본갑상선염여기염색체핵형류형무관.
Objective Turner syndrome (TS) is characterized with reduced adult height and gonadal dysgenesis and associated with a number of complications including thyroid disease.The purpose of this study was to investigate the prevalence of thyroid diseases and the association between thyroid autoantibodies (TAA) and thyroid dysfunction,age,and karyotype.Methods Fifty-five girls with TS were diagnosed by chromosome analyses and were divided into 2 groups according to whether there was TAA-positive or not:TAA-positive group and TAA-negative group.Thyroid autoantibodies (antithyroglobulin antibody,thyroperoxidase antibody),thyroid function (free T3,free T4,and TSH) were determined with immunochemiluminescent.Ultrasound was applied in TAA-positive group.Results Thyroid functions in 34 TAA-negative girls were normal.Of the 21 TAA-positive girls (21/55,38.2％),7 girls suffered from hypothyroidism and 3 girls had hyperthyroidism.All of 21 TAA-positive girls were diagnosed as cases of Hashimoto's thyroiditis.As compared with the girls in TAA-negative group,the age of girls in TAA-positive group was significantly higher [(12.16 ± 2.55 vs 9.95 ± 4.50) years,P＜0.05].6 cases under 5 years old were TAA-negative.31.3 ％ (5/16) of patients aged 5-10 years old,48.1％ (13/27) aged 10-15 years old and 50.0％ (3/6) above the age of 15 were TAA-positive.There were no significant differences in the numbers of TAApositive cases among different karyotypes (P ＞ 0.05).Thyroid ultrasound in girls with positive-TAA showed the abnormal echogenicity in bilateral lobus lateralis of thyroid.Conclusion Patients with TS are prone to suffer from Hashimoto's thyroiditis leading to thyroid dysfunction,when they are older than 5 years.Thyroid function should be evaluated yearly in girls with TS after 5 years old.There is no specific association between the incidence of autoimmune thyroid disease and certain karyotypes.
