CAJ | 학술논문

在中国华东地区育龄期女性中,探讨血清催乳素水平与胰岛素敏感性之间的相关性.共有211例育龄期女性纳入本研究,根据1998年世界卫生组织对于肥胖的诊断标准将受试者划分为正常体重组40名,超重组31例,肥胖组140例,所有受试者均进行75 g口服葡萄糖耐量试验评估机体糖耐量状况,并运用Bergman微小模型技术结合静脉糖耐量试验评估胰岛素敏感指数.超重组与肥胖组的血清催乳素水平显著高于正常体重组(24.91 ng/ml、27.07 ng/ml对8.06 ng/ml,P＜0.01),超重组与肥胖组之间催乳素水平无显著差异(P=0.366).多元逐步回归分析,校正混杂因素之后,发现血清催乳素水平与体重指数呈显著正相关(P＜0.01),与胰岛素敏感指数呈显著负相关(P=0.01).在中国华东地区的育龄期女性中,血清催乳素水平与胰岛素敏感性密切相关.
재중국화동지구육령기녀성중,탐토혈청최유소수평여이도소민감성지간적상관성.공유211례육령기녀성납입본연구,근거1998년세계위생조직대우비반적진단표준장수시자화분위정상체중조40명,초중조31례,비반조140례,소유수시자균진행75 g구복포도당내량시험평고궤체당내량상황,병운용Bergman미소모형기술결합정맥당내량시험평고이도소민감지수.초중조여비반조적혈청최유소수평현저고우정상체중조(24.91 ng/ml、27.07 ng/ml대8.06 ng/ml,P＜0.01),초중조여비반조지간최유소수평무현저차이(P=0.366).다원축보회귀분석,교정혼잡인소지후,발현혈청최유소수평여체중지수정현저정상관(P＜0.01),여이도소민감지수정현저부상관(P=0.01).재중국화동지구적육령기녀성중,혈청최유소수평여이도소민감성밀절상관.
To study the association between serum prolactin levels and insulin sensitivity in women of childbearing age in Eastern China.In the present study,211 women were enrolled and subdivided into normal weight group (n =40),overweight group (n =31),and obese group (n =140),according to the World Health Organization' s definition of obesity.All subjects received a standard 75 g oral glucose tolerance test.Insulin sensitivity index was assessed by the reduced sample number of Bergman's minimal model combined with intravenous glucose tolerance test.Serum prolactin levels in the overweight and obese subjects were significantly elevated when compared that in normal weight subjects(24.91 ng/ml,27.07 ng/ml vs 8.06 ng/ml,P＜0.01),but there was no significant difference between the levels in overweight and obese group(P =0.366).Multiple stepwise regression analysis showed that body mass index and insulin sensitivity index were independently associated with serum prolactin levels.Serum prolactin level is significantly associated with insulin sensitivity in women of child-bearing age.