CAJ | 학술논문

新生期是胰岛β细胞数量剧增和功能完善的重要时期.β细胞通过增殖、新生、凋亡等途径共同调控细胞量的扩增,机制涉及细胞周期相关蛋白、促有丝分裂信号通路等.此重塑阶段对于今后机体适应代谢需要和调节血糖内环境稳态具有深远影响.
신생기시이도β세포수량극증화공능완선적중요시기.β세포통과증식、신생、조망등도경공동조공세포량적확증,궤제섭급세포주기상관단백、촉유사분렬신호통로등.차중소계단대우금후궤체괄응대사수요화조절혈당내배경은태구유심원영향.
The neonatal period is important for the dramatic increment as well as function improvement of islet β-cell.β-cell mass augmentation is primarily regulated by neogenesis,replication,and apoptosis.The mechanisms involve cell cycle related proteins and mitosis-promoting signaling pathways.This remodeling period has far-reaching effects on the body in adapting to the metabolic needs and regulating glucose homeostasis later in life.