中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2013年
6期
490-493
,共4页
蔡雯%何方平%高锦凤%姚华
蔡雯%何方平%高錦鳳%姚華
채문%하방평%고금봉%요화
尿酸%肾小球滤过率%肾功能下降%中青年
尿痠%腎小毬濾過率%腎功能下降%中青年
뇨산%신소구려과솔%신공능하강%중청년
Uric acid%Glomerular filtration rate%Reduced renal function%Young and middle-aged people
目的 研究中青年体检人群生理血清尿酸水平与肾小球率过滤的相关性,探讨生理尿酸水平升高对肾功能下降的预测作用.方法 采用横断面调查方法,调查克拉玛依市社区体检人群6 532例和新疆医科大学第一附属医院体检人群2 402例,对研究对象进行问卷调查获取人口学资料,检测血液以及肝、肾功能生化指标；同时采用前瞻性队列研究方法,选择2008年新疆医科大学第一附属医院中青年肾功能正常健康体检人群752例,随访3年后其发生肾功能下降情况及影响因素.结果 在横断面调查中,生理血清尿酸水平均稳定成为肾小球滤过率下降的独立危险因素.按性别、年龄进行分层后,两组人群中除了第1组45岁以上女性人群外,其余各组人群生理血清尿酸均为估计肾小球滤过率(eGFR)下降的危险因素.队列研究中,通过随访3年后肾功能下降的发生率为15.40％,生理血清尿酸水平为肾小球滤过率下降的独立危险因素.结论 生理水平尿酸升高与肾脏功能下降密切相关且对早期肾功能下降具有预测价值.
目的 研究中青年體檢人群生理血清尿痠水平與腎小毬率過濾的相關性,探討生理尿痠水平升高對腎功能下降的預測作用.方法 採用橫斷麵調查方法,調查剋拉瑪依市社區體檢人群6 532例和新疆醫科大學第一附屬醫院體檢人群2 402例,對研究對象進行問捲調查穫取人口學資料,檢測血液以及肝、腎功能生化指標；同時採用前瞻性隊列研究方法,選擇2008年新疆醫科大學第一附屬醫院中青年腎功能正常健康體檢人群752例,隨訪3年後其髮生腎功能下降情況及影響因素.結果 在橫斷麵調查中,生理血清尿痠水平均穩定成為腎小毬濾過率下降的獨立危險因素.按性彆、年齡進行分層後,兩組人群中除瞭第1組45歲以上女性人群外,其餘各組人群生理血清尿痠均為估計腎小毬濾過率(eGFR)下降的危險因素.隊列研究中,通過隨訪3年後腎功能下降的髮生率為15.40％,生理血清尿痠水平為腎小毬濾過率下降的獨立危險因素.結論 生理水平尿痠升高與腎髒功能下降密切相關且對早期腎功能下降具有預測價值.
목적 연구중청년체검인군생리혈청뇨산수평여신소구솔과려적상관성,탐토생리뇨산수평승고대신공능하강적예측작용.방법 채용횡단면조사방법,조사극랍마의시사구체검인군6 532례화신강의과대학제일부속의원체검인군2 402례,대연구대상진행문권조사획취인구학자료,검측혈액이급간、신공능생화지표；동시채용전첨성대렬연구방법,선택2008년신강의과대학제일부속의원중청년신공능정상건강체검인군752례,수방3년후기발생신공능하강정황급영향인소.결과 재횡단면조사중,생리혈청뇨산수평균은정성위신소구려과솔하강적독립위험인소.안성별、년령진행분층후,량조인군중제료제1조45세이상녀성인군외,기여각조인군생리혈청뇨산균위고계신소구려과솔(eGFR)하강적위험인소.대렬연구중,통과수방3년후신공능하강적발생솔위15.40％,생리혈청뇨산수평위신소구려과솔하강적독립위험인소.결론 생리수평뇨산승고여신장공능하강밀절상관차대조기신공능하강구유예측개치.
Objective To investigate the association of serum uric acid level with glomerular filtration rate and explore the predictive value of the physiological uric acid levels for reduced renal function.Methods A total of 6 532 subjects from Karemary community and 2 402 subjects from the First Affiliated Hospital of Xinjiang Medical University were enrolled.All subjects were surveyed with questionnaire and their serum biochemical indices and liver functions were measured.Meanwhile,a cohort study was conducted,752 subjects with normal renal function were selected from young and middle-aged healthy people in 2008.During the 3-year follow-up,the incidence of reduced renal function and the risk factors of estimated glomerular filtration rate (eGFR) were analyzed.Results Serum uric acid (SUA) was the independent risk factor of reduced GFR in cross-sectional analysis.The 2 groups were stratified by sex and age,except for female population over 45 years old in the first group,the level of physiological serum uric acid was the risk factor for decreased eGFR in the rest of groups.During 3-year follow-up,the incidence of reduced renal function was 15.40％ and SUA was the independent risk factor of decreased eGFR.Conclusions The concentration of physiological serum uric acid was closely related with renal function,and the increase in SUA whthin normal range had an important early predictive value for decreased GFR.
