中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2013年
7期
584-585
,共2页
韩辉%黄佼%张险峰%屠巧峰%张楚
韓輝%黃佼%張險峰%屠巧峰%張楚
한휘%황교%장험봉%도교봉%장초
沙利度胺%甲状腺相关眼病%外周血单个核细胞%免疫调节
沙利度胺%甲狀腺相關眼病%外週血單箇覈細胞%免疫調節
사리도알%갑상선상관안병%외주혈단개핵세포%면역조절
Thalidomide%Thyroid-associated ophthalmopathy%Peripheral blood mononuclear cell%Immunoregulatory
探讨沙利度胺对甲状腺相关眼病(TAO)患者外周血单个核细胞(PBMC)的免疫调节作用.结果显示沙利度胺可抑制TAO患者PBMC的增殖,并能抑制肿瘤坏死因子α、干扰素γ、白细胞介素6的蛋白分泌和mRNA的表达,以达到免疫抑制的作用.
探討沙利度胺對甲狀腺相關眼病(TAO)患者外週血單箇覈細胞(PBMC)的免疫調節作用.結果顯示沙利度胺可抑製TAO患者PBMC的增殖,併能抑製腫瘤壞死因子α、榦擾素γ、白細胞介素6的蛋白分泌和mRNA的錶達,以達到免疫抑製的作用.
탐토사리도알대갑상선상관안병(TAO)환자외주혈단개핵세포(PBMC)적면역조절작용.결과현시사리도알가억제TAO환자PBMC적증식,병능억제종류배사인자α、간우소γ、백세포개소6적단백분비화mRNA적표체,이체도면역억제적작용.
The immunoregulatory effect of thalidomide on peripheral blood mononuclear cells in patients with thyroid-associated ophthalmopathy (TAO) was investigated.The resuhs showed that thalidomide (50 μg/ml)inhibited the proliferation of PBMC significantly.Thalidomide inhibitied tumor necrosis factor-α,IFN-γ,and interleukin-6 secretion,as well as mRNA expressions.
