CAJ | 학술논문

探讨高密度脂蛋白胆固醇(HDL-C)在新疆地区不同民族人群高尿酸血症发生中的异质性.调查汉族、维吾尔族和哈萨克族人群,检测血尿酸及血脂等相关生化指标.维吾尔族、汉族的HDL-C均为对照组高于高尿酸组,而哈萨克族HDL-C为高尿酸组高于对照组,哈萨克族血尿酸水平最低;相关性分析发现哈萨克族尿酸与HDL-C呈负相关(P＜0.05).HDL C是心血管相关疾病较为公认的保护因子,在哈萨克族人群中血尿酸水平较低时,随尿酸的升高HDLC也升高,当血尿酸水平高过一定标准(如高于本次分级SUA-4)时才对心血管疾病产生负面影响,提示应关注哈萨克族的特殊遗传性,为高尿酸血症的防治提供新思路.
탐토고밀도지단백담고순(HDL-C)재신강지구불동민족인군고뇨산혈증발생중적이질성.조사한족、유오이족화합살극족인군,검측혈뇨산급혈지등상관생화지표.유오이족、한족적HDL-C균위대조조고우고뇨산조,이합살극족HDL-C위고뇨산조고우대조조,합살극족혈뇨산수평최저;상관성분석발현합살극족뇨산여HDL-C정부상관(P＜0.05).HDL C시심혈관상관질병교위공인적보호인자,재합살극족인군중혈뇨산수평교저시,수뇨산적승고HDLC야승고,당혈뇨산수평고과일정표준(여고우본차분급SUA-4)시재대심혈관질병산생부면영향,제시응관주합살극족적특수유전성,위고뇨산혈증적방치제공신사로.
The heterogeneity of high-density lipoprotein-cholesterol (HDL-C) in hyperuricemia was analyzed in Uygur,Han,and Kazak ethnic groups in Xinjiang.A total of 2 396 subjects were surveyed.The HDL-C levels were significantly decreased in hyperuricemia group compared with control group in Han and Uygur,while the reverse occurred in Kazak.The serum uric acid (SUA) level in Kazak was the lowest.The SUA was negatively correlated with HDL C in Kazak (P ＜ 0.05).HDL-C was a recognized protective factor for cardiovascular disease.With the lowered SUA level in the Kazak group,HDL-C level was increased.When SUA level was higher than a certain level (such as the SUA-4),there existed a negative impact on cardiovascular disease