CAJ | 학술논문

将493例2型糖尿病患者按照是否服用二甲双胍分为双胍组和非双胍组,比较2组患者血清癌胚抗原(CEA)水平和生化特征,采用Pearson或Spearman相关分析和多元逐步回归分析影响CEA水平的因素.结果显示双胍组血清CEA水平明显低于非双胍组[(2.57±1.47对3.09±1.79)mmol/L,P＜0.01]；女性血清CEA水平明显低于男性[(2.48±1.41对3.12±1.78)mmol/L,P＜0.01],绝经后高于绝经前(P＜0.05).Spearman相关分析显示CEA与HbA1C、糖化血清白蛋白、应用二甲双胍、性别和睾酮呈显著相关(P＜0.01).多元逐步回归分析显示HbA1C(P＜0.01)、二甲双胍(P=0.019)、性别(P＜0.01)和睾酮(P＜0.01)是CEA的独立影响因素.提示2型糖尿病患者血清CEA水平存在性别差异,二甲双胍可降低2型糖尿病患者,尤其是女性患者的血清CEA水平.
장493례2형당뇨병환자안조시부복용이갑쌍고분위쌍고조화비쌍고조,비교2조환자혈청암배항원(CEA)수평화생화특정,채용Pearson혹Spearman상관분석화다원축보회귀분석영향CEA수평적인소.결과현시쌍고조혈청CEA수평명현저우비쌍고조[(2.57±1.47대3.09±1.79)mmol/L,P＜0.01]；녀성혈청CEA수평명현저우남성[(2.48±1.41대3.12±1.78)mmol/L,P＜0.01],절경후고우절경전(P＜0.05).Spearman상관분석현시CEA여HbA1C、당화혈청백단백、응용이갑쌍고、성별화고동정현저상관(P＜0.01).다원축보회귀분석현시HbA1C(P＜0.01)、이갑쌍고(P=0.019)、성별(P＜0.01)화고동(P＜0.01)시CEA적독립영향인소.제시2형당뇨병환자혈청CEA수평존재성별차이,이갑쌍고가강저2형당뇨병환자,우기시녀성환자적혈청CEA수평.
Serum carcino embryonic antigen (CEA) levels were measured and compared in 493 patients with type 2 diabetes including one group receiving,and another group without metformin treatment.Associations between CEA and other variables were assessed with Spearman or Pearson correlation analysis and multiple stepwise regression analysis.The results showed that CEA level in metformin group was significantly lower than that in nonmetformim group[(2.57 ± 1.47 vs 3.09 ± 1.79) mmol/L,P＜0.01] ; CEA level in females was significantly lower than that of males [(2.48 ± 1.41 vs 3.12 ± 1.78) mmol/L,P＜0.01] ; CEA level in postmenopausal women was significantly higher than that in premenopausal women (P＜0.05).The correlation analysis showed that serum CEA levels were significantly associated with HbA1C,glycated albumin,metformin,gender,and testosterone (P ＜0.01).Multiple stepwise regression analysis further revealed that HbA1C(P＜0.01),metformin administration (P =0.019),gender(P＜0.01),and T levels (P＜0.01) were independent influencing factors of CEA concentrations.These results suggest that there is gender difference in serum CEA levels in type 2 diabetic patients.Metformin may reduce serum CEA levels in type 2 diabetic patients,especially in the female patients.