CAJ | 학술논문

骨细胞是一种应力传感器,指挥协调骨重建.骨细胞死亡在启动骨重建中起关键作用.骨细胞分泌的硬化素反馈抑制骨形成,抑制硬化素的作用已成为治疗骨质疏松的新靶点.了解骨细胞的作用对指导治疗代谢性骨病有重要意义.
골세포시일충응력전감기,지휘협조골중건.골세포사망재계동골중건중기관건작용.골세포분비적경화소반궤억제골형성,억제경화소적작용이성위치료골질소송적신파점.료해골세포적작용대지도치료대사성골병유중요의의.
The osteocyte has been found to be an orchestrator of bone remodeling.The damage of bone leads to osteocyte apoptosis.Sclerostin secreted by osteocyte causes feedback inhibition of bone formation,so inhibition of sclerostin expression has become a new target of treatment for osteoporosis.It seems resonable to direct clinical practise and treatment of metabolic bone diseases through understanding the function of osteocyte in the process of bone remodeling.