CAJ | 학술논문

目的评估2型糖尿病患者日常临床环境中发生夜间低血糖的危险因素,寻求预测夜间低血糖发生的量化指标.探讨临床干预危险因素后的效应.方法对血糖控制达标的2型糖尿病患者1147例,应用动态血糖监测系统(CGMS)监测全天血糖(BG)变化,比较不同晚餐后3h血糖两组间夜间低血糖发生率.结果低血糖、无症状低血糖及夜间低血糖发生率分别为37.23％、22.75％和18.31％.22:00～2:00是夜间低血糖的高发时间段(RR=1.72,x2=31.667,P＜0.01).干预组夜间低血糖发生率较对照组明显降低(9.67％对16.76％,x2=8.79,P＜0.01).结论 2型糖尿病患者夜间低血糖发生率高,22:00～2:00是夜间低血糖的高发时间段,适当干预可以降低夜间低血糖的发生.
목적 평고2형당뇨병환자일상림상배경중발생야간저혈당적위험인소,심구예측야간저혈당발생적양화지표.탐토림상간예위험인소후적효응.방법 대혈당공제체표적2형당뇨병환자1147례,응용동태혈당감측계통(CGMS)감측전천혈당(BG)변화,비교불동만찬후3h혈당량조간야간저혈당발생솔.결과 저혈당、무증상저혈당급야간저혈당발생솔분별위37.23％、22.75％화18.31％.22:00～2:00시야간저혈당적고발시간단(RR=1.72,x2=31.667,P＜0.01).간예조야간저혈당발생솔교대조조명현강저(9.67％대16.76％,x2=8.79,P＜0.01).결론 2형당뇨병환자야간저혈당발생솔고,22:00～2:00시야간저혈당적고발시간단,괄당간예가이강저야간저혈당적발생.
Objective To investigate risk factors of nocturnal hypoglycemia in patients with type 2 diabetes mellitus,to seek quantitative indicators for early warning,and to evaluate the effects of intervention.Methods 24-h blood glucose of 1147 patients with type 2 diabetes mellitus with well-controlled hyperglycemia were determined by continuous glucose monitoring system (CGMS).Incidences of hypoglycemia were compared between groups with different 3 h postprandial blood glucose levels after supper.Results The rates of hypoglycemia,asymptomatic hypoglycemia,and nocturnal hypoglycemia were respectively 37.23％,22.75％,and 18.31％.Nocturnal hypoglycemia set in most frequently by 22:00-2:00 (RR =1.72,x2 =31.667,P＜0.01).The hypoglycemia incidence was reduced in intervention group than that in control group (9.67％ vs 16.76％,x2 =8.79,P ＜0.01).Conclusions Nocturnal hypoglycemia happens commonly in patients with type 2 diabetes.It usually sets in by 22:00-2:00.Appropriate intervention may prevent the hypoglycemic events.